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      • Higher levels of self-efficacy and readiness for a future career among Spanish-speaking physician assistant students after their volunteer work at a student-run free clinic in the United States

        Shannon Weaver,Zainub Hussaini,Virginia Lynn Valentin,Samin Panahi,Sarah Elizabeth Levitt,Jeanie Ashby,Akiko Kamimura 한국보건의료인국가시험원 2019 보건의료교육평가 Vol.16 No.-

        Volunteering at a free clinic may influence career choice among health profession students. The purpose of this study was to explore knowledge, skills, attitudes, self-efficacy, interest in future work with the underserved, and interest in primary care among physician assistant (PA) students through an analysis of demographic characteristics of PA students at a student-run free clinic in the United States. Data were collected from 56 PA students through a quantitative survey in October 2018 after their participation at a student-run free clinic in Salt Lake City, Utah, in the intermountain west region of the USA. Out of the 3 sub-scales (attitudes, effect, and readiness), students responded most positively to items exploring the effect of their experiences of volunteering at the free clinic. Students who spoke Spanish showed higher levels of self-efficacy and readiness for a future career than non-Spanish speakers.

      • New Era Nutrition and Food Research is Leading Us Beyond Essential Nutrients

        Connie M. Weaver 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10

        Dietary guidance and nutrient recommendations have traditionally been based on meeting essential nutrient needs to prevent nutrient deficiencies. The explosion of interest in bioactive constituents and functional foods for promoting health and resiliency to prevent chronic disease is raising questions about what kind of research is needed to create a rigorous evidence based for setting food guidance policy and what the process should be for developing the policies. A chronic disease risk reduction category was developed and applied first to sodium and potassium. A Dietary Reference Intake-type proposed process for bioactive foods and beverages was recently developed. Best practices for designing and conducting human nutrition clinical trials were published in a series of articles in Advances in Nutrition in 2020 and 2021. Key elements will be highlighted from our dose response randomized, controlled trial of blueberries and bone health in postmenopausal women that will be featured in Frontiers in Nutrition. New tools for identifying biomarkers of exposure and outcome measures are launching an era of personalized nutrition.

      • KCI등재

        Evaluation of Neutron Cross Sections for Hafnium in the Resolved Resonance Range

        T. Ware,D. Weaver,M. Moxon,C. Dean,R. Hiles,P. Schillebeeckx,S. Kopecky 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.23

        The international High Priority Request list notes: - "In the nuclear industry hafnium is used as neutron absorbing material to regulate the fission process. Interpretation of critical experiments with UOx fuel conducted by CEA in the AZUR zero-power reactors has shown systematic underestimation of the reactivity worth that may be attributed to an overestimated natural hafnium capture cross section in the epi-thermal energy range"To service the request for improved resonance data a PhD project has:-a) Improved REFIT R-matrix evaluation code.b) Obtained hafnium oxide samples enriched in Hf176, 177, 178, 179 isotopes.c) Gained support from NUDAME and EUFRAT projects.d) Prepared enriched and natural Hf samples.e) Performed capture and transmission Time of Flight measurements at the GELINA linear accelerator.f) Analysed the capture counts to generate yields using AGS and AGL codes.g) Used REFIT to perform least squares analysis of GELINA measurements.(Included previous ORNL, Harwell and RPI transmissions and capture yields.)h) Submitted results to EXFOR.i) Included resolved resonance parameters in JEFF evaluations taking the resolved range to over 1keV. j) Tested evaluations with suitable benchmarks.k) Passed resolved resonance data to CEA Cadarache for unresolved analysis.Resultant Hf evaluations will be included in JEFF3.2.

      • SCISCIESCOPUS

        HUBBLE SPACE TELESCOPE INVESTIGATION OF MAIN-BELT COMET 133P/ELST-PIZARRO

        Jewitt, David,Ishiguro, Masateru,Weaver, Harold,Agarwal, Jessica,Mutchler, Max,Larson, Steven American Institute of Physics 2014 The Astronomical journal Vol.147 No.5

        <P>We report new observations of the prototype main-belt comet (active asteroid) 133P/Elst-Pizarro taken at high angular resolution using the Hubble Space Telescope. The object has three main components: (1) a point-like nucleus; (2) a long, narrow antisolar dust tail; and (3) a short, sunward anti-tail. There is no resolved coma. The nucleus has a mean absolute magnitude H<SUB>V</SUB> = 15.70 ± 0.10 and a light curve range ΔV = 0.42 mag, the latter corresponding to projected dimensions 3.6 × 5.4 km (axis ratio 1.5:1) at the previously measured geometric albedo of 0.05 ± 0.02. We explored a range of continuous and impulsive emission models to simultaneously fit the measured surface brightness profile, width, and position angle of the antisolar tail. Preferred fits invoke protracted emission, over a period of 150 days or less, of dust grains following a differential power-law size distribution with index 3.25 ≤q ≤ 3.5 and with a wide range of sizes. Ultra-low surface brightness dust projected in the sunward direction is a remnant from emission activity occurring in previous orbits, and consists of the largest (≥cm-sized) particles. Ejection velocities of one-micron-sized particles are comparable to the ~1.8 m s<SUP>–1</SUP> gravitational escape speed of the nucleus, while larger particles are released at speeds less than the gravitational escape velocity. The observations are consistent with, but do not prove, a hybrid hypothesis in which mass loss is driven by gas drag from the sublimation of near-surface water ice, but escape is aided by centripetal acceleration from the rotation of the elongated nucleus. No plausible alternative hypothesis has been identified.</P>

      • FRAGMENTATION KINEMATICS IN COMET 332P/IKEYA-MURAKAMI

        Jewitt, David,Mutchler, Max,Weaver, Harold,Hui, Man-To,Agarwal, Jessica,Ishiguro, Masateru,Kleyna, Jan,Li, Jing,Meech, Karen,Micheli, Marco,Wainscoat, Richard,Weryk, Robert American Astronomical Society 2016 ASTROPHYSICAL JOURNAL LETTERS - Vol.829 No.1

        <P>We present initial time-resolved observations of the split comet 332P/Ikeya-Murakami taken using the Hubble Space Telescope. Our images reveal a dust-bathed cluster of fragments receding from their parent nucleus at projected speeds in the range 0.06-3.5 m s(-1) from which we estimate ejection times from 2015 October to December. The number of fragments with effective radii greater than or similar to 20 m follows a differential power law with index gamma = -3.6 +/- 0.6, while smaller fragments are less abundant than expected from an extrapolation of this power law. We argue that, in addition to losses due to observational selection, torques from anisotropic outgassing are capable of destroying the small fragments by driving them quickly to rotational instability. Specifically, the spin-up times of fragments. 20 m in radius are shorter than the time elapsed since ejection from the parent nucleus. The effective radius of the parent nucleus is re <= 275 m (geometric albedo 0.04 assumed). This is about seven times smaller than previous estimates and results in a nucleus mass at least 300 times smaller than previously thought. The mass in solid pieces, 2 x 10(9) kg, is about 4% of the mass of the parent nucleus. As a result of its small size, the parent nucleus also has a short spin-up time. Brightness variations in time-resolved nucleus photometry are consistent with rotational instability playing a role in the release of fragments.</P>

      • SCIESCOPUSKCI등재

        In Vitro Transcription Analysis of Autographa californica Nuclear Polyhedrosis Virus Genes

        HUH, NAM-EUNG,WEAVER, ROVERT F. 한국미생물 · 생명공학회 1994 Journal of microbiology and biotechnology Vol.4 No.3

        Cell-free extracts prepared from cultured insect cells, Spodoptera frugiperda, were analyzed for activation of early gene transcription of an insect baculovirus, Autographa californica nuclear polyhedrosis virus (AcNPV). The template DNA used for in vitro transcription assays contained promoter sites for the baculovirus genes that have been classified as immediate early (α) or early genes. These genes are located in the HindⅢ-K/Q region of the AcNPV genome. Nuclei isolated from the AcNPV-infected Spodoptera frugiperda cells were also used for in vitro transcription analysis by RNase-mapping the Labeled RNA synthesized from in vitro run-on reaction in the isolated nuclei. The genes studied by this technique were p26 and p10 genes which were classified as delayed early and late gene, respectively. We found that transcription of the genes from the HindⅢ-K region was accurately initiated and unique in the whole cell extract obtained from uninfected cells, although abundance of the in vitro transcripts was reverse to that of in vivo RNA. With isolated nuclei transcription of the p26 gene was inhibited by α-amanitin suggesting that the p26 gene was transcribed by host RNA polymerase Ⅱ. However, transcription of the p10 gene in isolated nuclei was not inhibited by α-amanitin, but rather stimulated by the inhibitor. We also found that the synthesis of α-amanitin-resistant RNA polymerase was begun before 6 hr p.i., the time point at which the onset of viral DNA replication as well as the appearance of α-amanitin-resistant viral transcripts were detected. These studies give us strong evidence to support the previous data that early genes of AcNPV were transcribed by host RNA polymerease Ⅲ, while transcription of late genes was mediated at least by a novel α-amanitin-resistant RNA polymerase.

      • Determinants of Paclitaxel Penetration and Accumulation in Human Solid Tumor

        Jang, Seong. H.,Weaver, Jean R.,Wientjes, M. Guillaume,Kuh, Hyo-Jeong,Au, Jessie L.-S. 가톨릭대학교 2000 Bulletin of The Catholic Research Institutes of Me Vol.28 No.-

        The present study examined the determinants of the penetration and accumulation of [(3)H]paclitaxel (12-12,000 nM) in three-dimensional histocultures of patient tumors and of a human xenograft tumor in mice. The results showed 1) significant and saturable drug accumulation in tumors, 2) extensive drug retention in tumors, and 3) an slower penetration but a more extensive accumulation in the xenograft tumor compared with patient tumors. Drug penetration was not rate-limited by drug diffusion from medium through the matrx supporting the histocultures. The difference in the expression of the mdr1 P-glycoprotein did not fully account for the difference in the drug accumulation in xenograft and patient tumors. Autoradiography and imaging were used to evaluate the spatial relationship between tumor architecture, tumor cell distribution, and drug distribution as a function of time and initial drug concentration in culture medium. The tumor cell density and the kinetics of drug-induced apoptosis were also evaluated. The results indicate that a high tumor cell density is a barrier to paclitaxel penetration and that the apoptotic effect of paclitaxel enhances its penetration in solid tumor. These factors are responsible for the time- and concentration-dependent drug penetration rate, with drug penetration confined to the periphery until apoptosis and reduction of epithelial cell density occurred at 24 h, after which time paclitaxel penetrated the inner part of the tumor. (Journal of Pharmacology and Experimental Therapeutics. 290(2):871-880, 1999)

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