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- 저자 : Wang Huanbo (검색결과 2 건)
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Mao Jianxin,Wang Di,Wang Dong,Wu Qi,Shang Qiliang,Gao Chu,Wang Huanbo,Wang Han,Du Mu,Peng Pandi,Jia Haoruo,Xu Xiaolong,Wang Jie,Yang Liu,Luo Zhuojing 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Mitochondrial dysfunction plays a major role in the development of intervertebral disc degeneration (IDD). Sirtuin 5 (SIRT5) participates in the maintenance of mitochondrial homeostasis through its desuccinylase activity. However, it is still unclear whether succinylation or SIRT5 is involved in the impairment of mitochondria and development of IDD induced by excessive mechanical stress. Our 4D label-free quantitative proteomic results showed decreased expression of the desuccinylase SIRT5 in rat nucleus pulposus (NP) tissues under mechanical loading. Overexpression of Sirt5 effectively alleviated, whereas knockdown of Sirt5 aggravated, the apoptosis and dysfunction of NP cells under mechanical stress, consistent with the more severe IDD phenotype of Sirt5 KO mice than wild-type mice that underwent lumbar spine instability (LSI) surgery. Moreover, immunoprecipitation-coupled mass spectrometry (IP-MS) results suggested that AIFM1 was a downstream target of SIRT5, which was verified by a Co-IP assay. We further demonstrated that reduced SIRT5 expression resulted in the increased succinylation of AIFM1, which in turn abolished the interaction between AIFM1 and CHCHD4 and thus led to the reduced electron transfer chain (ETC) complex subunits in NP cells. Reduced ETC complex subunits resulted in mitochondrial dysfunction and the subsequent occurrence of IDD under mechanical stress. Finally, we validated the efficacy of treatments targeting disrupted mitochondrial protein importation by upregulating SIRT5 expression or methylene blue (MB) administration in the compression-induced rat IDD model. In conclusion, our study provides new insights into the occurrence and development of IDD and offers promising therapeutic approaches for IDD.
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Recycling Carbon Fiber/Epoxy Resin Composites by Thermal Excitation Oxide Semiconductors
Huanbo Cheng,Yu Sun,Xin Wang,Jiahua Chang,Deqi Jing 한국섬유공학회 2019 Fibers and polymers Vol.20 No.4
A novel method was proposed for recycling the composites by thermal excitation oxide semiconductors. Thedecomposition ability of TiO2 and Cr2O3 was investigated based on analysis of effects of the temperature and time ondecomposition rate of the epoxy resin. The microstructure, graphitization degree and mechanical properties of the recycledcarbon fiber were investigated, and the effects of O2 on the decomposition were analyzed. The results indicated that TiO2 andCr2O3 had excellent decomposition ability on CF/EP composites at 350-500 oC; Cr2O3 was more suitable to decomposecomposites due to its high purity and good thermal stability against TiO2; the temperature and time were positively correlatedwith the decomposition rate of epoxy resin, and the influence intensity of the temperature was higher than that of the time; O2could promote recycling by oxidation of the carbon deposit and supporting combustion, and the IG/ID of the recycled carbonfiber was significantly lower than that of original carbon fiber; the monofilament tensile strength of the recycled carbon fiberwas 87 % of that of the original carbon fiber at 500 oC, 15 min and the flow rate of 100 ml/min (99.999 % O2).
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