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Invited Paper : On the Performance of Oracle Grid Engine Queuing System for Computing Intensive Applications

( Vladi Kolici ),( Albert Herrero ),( Fatos Xhafa ) 한국정보처리학회 2014 Journal of information processing systems Vol.10 No.4
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In this paper we present some research results on computing intensive applications using modern high performance architectures and from the perspective of high computational needs. Computing intensive applications are an important family of applications in distributed computing domain. They have been object of study using different distributed computing paradigms and infrastructures. Such applications distinguish for their demanding needs for CPU computing, independently of the amount of data associated with the problem instance. Among computing intensive applications, there are applications based on simulations, aiming to maximize system resources for processing large computations for simulation. In this research work, we consider an application that simulates scheduling and resource allocation in a Grid computing system using Genetic Algorithms. In such application, a rather large number of simulations is needed to extract meaningful statistical results about the behavior of the simulation results. We study the performance of Oracle Grid Engine for such application running in a Cluster of high computing capacities. Several scenarios were generated to measure the response time and queuing time under different workloads and number of nodes in the cluster.
2
On the Performance of Oracle Grid Engine Queuing System for Computing Intensive Applications

Kolici, Vladi,Herrero, Albert,Xhafa, Fatos Korea Information Processing Society 2014 Journal of information processing systems Vol.10 No.4
- 원문보기
In this paper we present some research results on computing intensive applications using modern high performance architectures and from the perspective of high computational needs. Computing intensive applications are an important family of applications in distributed computing domain. They have been object of study using different distributed computing paradigms and infrastructures. Such applications distinguish for their demanding needs for CPU computing, independently of the amount of data associated with the problem instance. Among computing intensive applications, there are applications based on simulations, aiming to maximize system resources for processing large computations for simulation. In this research work, we consider an application that simulates scheduling and resource allocation in a Grid computing system using Genetic Algorithms. In such application, a rather large number of simulations is needed to extract meaningful statistical results about the behavior of the simulation results. We study the performance of Oracle Grid Engine for such application running in a Cluster of high computing capacities. Several scenarios were generated to measure the response time and queuing time under different workloads and number of nodes in the cluster.
3
Mbd2-CP2c loop drives adult-type globin gene expression and definitive erythropoiesis

Kim, Min ,Young,Kim, Ji ,Sook,Son, Seung ,Han,Lim, Chang ,Su,Eum, Hea ,Young,Ha, Dae ,Hyun,Park, Mi ,Ae,Baek, Eun ,Jung,Ryu, Buom-Yong,Kang, Ho ,Chul,Uversky, Vladi Oxford University Press 2018 Nucleic acids research Vol.46 No.10
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AbstractDuring hematopoiesis, red blood cells originate from the hematopoietic stem cell reservoir. Although the regulation of erythropoiesis and globin expression has been intensively investigated, the underlining mechanisms are not fully understood, including the interplay between transcription factors and epigenetic factors. Here, we uncover that the Mbd2-free NuRD chromatin remodeling complex potentiates erythroid differentiation of proerythroblasts via managing functions of the CP2c complexes. We found that both Mbd2 and Mbd3 expression is downregulated during differentiation of MEL cells in vitro and in normal erythropoiesis in mouse bone marrow, and Mbd2 downregulation is crucial for erythropoiesis. In uninduced MEL cells, the Mbd2-NuRD complex is recruited to the promoter via Gata1/Fog1, and, via direct binding through p66α, it acts as a transcriptional inhibitor of the CP2c complexes, preventing their DNA binding and promoting degradation of the CP2c family proteins to suppress globin gene expression. Conversely, during erythropoiesis in vitro and in vivo, the Mbd2-free NuRD does not dissociate from the chromatin and acts as a transcriptional coactivator aiding the recruitment of the CP2c complexes to chromatin, and thereby leading to the induction of the active hemoglobin synthesis and erythroid differentiation. Our study highlights the regulation of erythroid differentiation by the Mbd2-CP2c loop.