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RISS 인기검색어
- 검색키워드
- 저자 : Viswanathamurthi, Periasamy (검색결과 2 건)
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Hydrophilic nanofibrous structure of polylactide; fabrication and cell affinity
Bhattarai, Shanta Raj,Bhattarai, Narayan,Viswanathamurthi, Periasamy,Yi, Ho Keun,Hwang, Pyoung Han,Kim, Hak Yong Wiley Publishers 2006 Journal of Biomedical Materials Research Part A Vol. No.
<P>Microstructure and architecture of the scaffolds along with the surface chemistry exert profound effect on biological activity (cell distribution, proliferation, and differentiation). For the biological activity, scaffolds in tissue engineering have been widely designed. The objective of this study was to develop hydrophilic nanofibrous structure of polylactides (PLLA) polymer in the form of nonwoven mat by electrospinning technique, and further evaluate the fibroblast NIH3T3 cell proliferation, morphology, and cell–matrix interaction. Hydrophilicity of the PLLA fibers was improved by adding small fraction of low molecular weight polyethylene glycol (PEG) into the electrospinning solution. Four different ratio types (100/0, 80/20, 70/30, and 50/50) of PLLA/PEG electrospun matrices were fabricated, and the pore characteristics, tensile properties, contact angle, and hydrolytic degradation were observed. Furthermore, scanning electron microscope (SEM) and fluorescence actin staining images were used for micro-observation of cell–matrix interaction and cell morphology. It was found that the electrospun mat of PLLA/PEG (80/20), composed of fibers with diameters in the range 540–850 nm, majority of pore diameter less than 100 μm, tensile strength 8 MPa, elongation 150%, porosity more than 90%, and improved hydrophilicity with slow hydrolytic degradation, is favorable for biological activity of NIH3T3 fibroblast cell. Based on these results, the correct composition of PLLA and PEG in the porous electrospun matrix (i.e., PLLA/PEG (80/20)) will be a better candidate rather than other compositions of PLLA/PEG as well as hydrophobic PLLA for application in tissue engineering. © 2006 Wiley Periodicals, Inc. J Biomed Mater Res, 2006</P>
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Tridax Procumbens Extract Loaded Electrospun PCL Nanofibers: A Novel Wound Dressing Material
Mathiazhagan Suryamathi,Chidhambaram Ruba,Periasamy Viswanathamurthi,Velramar Balasubramanian,Pachiappan Perumal 한국고분자학회 2019 Macromolecular Research Vol.27 No.1
To overcome the bacterial infection which may leads to strain the wounds progressively, wound healing medicinal plant was choosen to treat the infection caused by bacteria. Though the medicinal wound healing plants are resistant to bacteria, the bare plant extract may face poor contact with the wound. This necessitate for a carrier for the plant extract. Polycaprolactone (PCL) electrospun nanofibers have been selected as carrier in this work due to its beneficial surface property and biocompatibility. Extract from the medicinal plant Tridax procumbens was immobilized on PCL electrospun nanofibers. The PCL nanofiber and Tridax procumbens extract immobilized nanofibers were characterized by SEM, XRD and EDAX. The morphology, porosity, swelling and weight loss percentage of the electrospun nanofibers have been investigated. The Tridax procumbens-PCL nanofibers were analyzed for its anti-bacterial activity. The results of the work confess that the scaffolds act as an enhancer of wound healing and treating surfaces that contain pathogenic microorganisms especially in hospital environment.
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