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Curcumin-PVP Loaded Electrospun Membranes with Conferred Antibacterial and Antitumoral Activities
Gyuldzhan Yakub,Antoniya Toncheva,Veselin Kussovski,Reneta Toshkova,Ani Georgieva,Elena Nikolova,Nevena Manolova,Iliya Rashkov 한국섬유공학회 2020 Fibers and polymers Vol.21 No.1
Electrospun membranes containing curcumin were prepared from poly(L-co-D,L-lactic) acid and polyvinylpyrrolidone. The effect of curcumin concentration on the solution viscosity and the morphology of fiber was studied. Curcumin solubility in aqueous solutions was enhanced by the formation of curcumin/polyvinylpyrrolidone watersoluble complex. Curcumin physico-chemical and therapeutic properties within the membranes were preserved upon UV-Vislight irradiation, as a part of the membranes sterilization. The biomaterials showed antibacterial activity against pathogenic microorganisms such as Staphylococcus aureus and Candida albicans. In-vitro experiments against HeLa and Graffi tumor cells and white blood cells (peritoneal macrophages and spleen lymphocytes) revealed potential biomedical application of the membranes.
Mariana Nikolova,Gabriela Ambrozova,Maria Kratchanova,Petko Denev,Veselin Kussovski,Milan Ciz,Antonin Lojek 한국식품영양과학회 2013 Journal of medicinal food Vol.16 No.8
The current survey investigates the effect of four polysaccharides isolated from fresh leek or alcohol insoluble substances (AIS) of leek on the production of reactive oxygen species (ROS) and reactive nitrogen species (RNS) from phagocytes. The ability of the polysaccharides to activate serum complement was also investigated. Despite the lack of antioxidant activity, the pectic polysaccharides significantly decreased the production of ROS by human neutrophils. Polysaccharides isolated from AIS markedly activated RAW 264.7 macrophages for RNS production in a concentration-dependent manner. The Western blot analysis revealed that this effect was due to the stimulation of the inducible nitric oxide synthase protein expression of macrophages. The polysaccharides extracted from AIS with water showed the ability to fix serum complement, especially through the alternative pathway. It was found that the polysaccharide that has the highest complement-fixing effect is characterized by the highest content of uronic acids and the highest molecular weight.