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- 저자 : Venkat P. P. K (검색결과 4 건)
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Hiren V. Trada,Venkat Vendra,Joseph P. Tinney,Fangping Yuan,Douglas J. Jackson,Kevin M. Walsh,Bradley B. Keller 한국바이오칩학회 2015 BioChip Journal Vol.9 No.2
We have designed, fabricated, and validated a novel porous, multielectrode array (P-MEA) device capable of low-voltage electrical stimulation of engineered cardiac tissues (ECTs). The primary advantage of this device is the ability to successfully function at a very low voltage thus minimizing any undesirable oxidative by-products in the culture environment or cell injury. Major features of our P-MEA include dimensions of 10 mm width and 82 mm length, four arms to allow movement of the individual pads within ECTs, each embedded electrode arm incorporates eight 100 μm×200 μm rectangular pores surrounding a 950 μm×340 μm exposed electrode, large pads on either side of the porous embedded device to function as current return electrodes, suture holes to aid in vivo suturing and stabilization, and an eight electrode connector pads. Average thickness of the Ni/Au electrodes was 20 nm of nickel and 400 nm of old, an average electrode film thickness of 0.4 μm, and a double polyimide layer thickness of 16 μm. Electrode resistance ranged from 69.45 Ω to 78.52 Ω. Electrochemical impedance spectroscopy confirmed that the P-MEA operates in the 0.01 V to 1.0 V range with favorable charge transfer characteristics. Proof of principle experiments confirmed the ability of the P-MEA to effectively embed within ECT and electricallystimulate ECT during chronic, in vitro culture. Histology imaging shows that the embedding of the device has no adverse effects on the ECT and the cardiomyocytes are aligned within the tissue. Experiments are ongoing to evaluate the role of electrical stimulation on the maturation and function of ECTs. We have designed, fabricated, and validated a novel porous, multielectrode array (P-MEA) device capable of low-voltage electrical stimulation of engineered cardiac tissues (ECTs). The primary advantage of this device is the ability to successfully function at a very low voltage thus minimizing any undesirable oxidative by-products in the culture environment or cell injury. Major features of our P-MEA include dimensions of 10 mm width and 82 mm length, four arms to allow movement of the individual pads within ECTs, each embedded electrode arm incorporates eight 100 μm×200 μm rectangular pores surrounding a 950 μm×340 μm exposed electrode, large pads on either side of the porous embedded device to function as current return electrodes, suture holes to aid in vivo suturing and stabilization, and an eight electrode connector pads. Average thickness of the Ni/Au electrodes was 20 nm of nickel and 400 nm of gold, an average electrode film thickness of 0.4 μm, and a double polyimide layer thickness of 16 μm. Electrode resistance ranged from 69.45 Ω to 78.52 Ω. Electrochemical impedance spectroscopy confirmed that the P-MEA operates in the 0.01 V to 1.0 V range with favorable charge transfer characteristics. Proof of principle experiments confirmed the ability of the P-MEA to effectively embed within ECT and electrically stimulate ECT during chronic, in vitro culture. Histology imaging shows that the embedding of the device has no adverse effects on the ECT and the cardiomyocytes are aligned within the tissue. Experiments are ongoing to evaluate the role of electrical stimulation on the maturation and function of ECTs.
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Chaluvally-Raghavan, P.,Zhang, F.,Pradeep, S.,Hamilton, Mark P.,Zhao, X.,Rupaimoole, R.,Moss, T.,Lu, Y.,Yu, S.,Pecot, Chad V.,Aure, Miriam R.,Peuget, S.,Rodriguez-Aguayo, C.,Han, H.D.,Zhang, D.,Venkat Cell Press 2014 CANCER CELL Vol.26 No.6
Small noncoding miRNAs represent underexplored targets of genomic aberrations and emerging therapeutic targets. The 3q26.2 amplicon is among the most frequent genomic aberrations in multiple cancer lineages including ovarian and breast cancers. We demonstrate that hsa-miR-569 (hereafter designated as miR569), which is overexpressed in a subset of ovarian and breast cancers, at least in part due to the 3q26.2 amplicon, alters cell survival and proliferation. Downregulation of TP53INP1 expression by miR569 is required for the effects of miR569 on survival and proliferation. Targeting miR569 sensitizes ovarian and breast cancer cells overexpressing miR569 to cisplatin by increasing cell death both in vitro and in vivo. Thus targeting miR569 could potentially benefit patients with the 3q26.2 amplicon and subsequent miR569 elevation.
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India 2014: Facebook ‘Like’ as a Predictor of Election Outcomes
Francis P. Barclay,C. Pichandy,Anusha Venkat,Sreedevi Sudhakaran 서울대학교행정대학원 2015 Asian Journal of Political Science Vol.23 No.2
Can the count of ‘likes’ recorded on the Facebook page of a party predict whether it will win the elections or not? To answer this question in the Indian setting in the context of the 2014 Lok Sabha elections, the political trend on Facebook was estimated using the numbers of ‘likes’ recorded on verified Facebook fan pages during the period of study—24 January to 12 May 2014. A strong positive correlation was found to exist between the number of ‘likes’ a party or its leader secured on their official Facebook fan page and their popular vote share. A single latent variable—presumably, the political preferences of the people—explained 91.37% of the total variance in those two variables. Furthermore, the time period during which the ‘likes’ were recorded was found to have a moderating effect on the positive relationship between the ‘likes’ and votes. It was found that the month preceding the voting period was the best to predict the vote share using ‘likes’—with 86.6% accuracy.
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