RISS 검색 - 국내학술지논문

무료
기관 내 무료
유료

내보내기
내책장담기
한글로보기

정확도순

내림차순

내림차순

10개씩 출력

1
Evaluation of the antinociceptive effects of a selection of triazine derivatives in mice

Valiollah Hajhashemi,Ghadamali Khodarahmi,Parvin Asadi,Hamed Rajabi 대한통증학회 2022 The Korean Journal of Pain Vol.35 No.4
- 원문보기 3
 ScienceON
 
 KCI
 
 KISS
Background: The authors showed in a previous study that some novel triazine derivatives had an anti-inflammatory effect. The present study was designed to evaluate the antinociceptive effect of five out of nine compounds including two vanillintriazine (5c and 5d) and three phenylpyrazole-triazine (10a, 10b, 10e) derivatives which showed the best anti-inflammatory effect. Methods: Male Swiss mice (25–30 g) were used. To assess the antinociceptive effect, acetic acid-writhing, formalin, and hot plate tests were used after intraperitoneal injection of each compound. Results: All compounds significantly (P < 0.001) reduced acetic acid-induced writhing at tested doses (50, 100, and 200 mg/kg). Also, the percent inhibition of writhing in the acetic acid test showed that at the maximum tested dose of these compounds (200 mg/kg), the order of potencies is as follows: 10b > 10a > 10e > 5d > 5c. In the formalin test, compounds 5d, 10a, and 10e showed an antinociceptive effect in the acute phase and all compounds were effective in the chronic phase. In the hot plate test, compounds 5c, 5d, and 10a demonstrated an antinociceptive effect. Conclusions: The results clearly showed that both vanillin-triazine and phenylpyrazole- triazine derivatives had an antinociceptive effect. Also, some compounds which showed activity in the early phase of formalin test as well as in the hot plate test could control acute pain in addition to chronic or inflammatory pain.
2
Anti-inflammatory and antinociceptive effects of sitagliptin in animal models and possible mechanisms involved in the antinociceptive activity

( Valiollah Hajhashemi ),( Hossein Sadeghi ),( Fatemeh Karimi Madab ) 대한통증학회 2024 The Korean Journal of Pain Vol.37 No.1
- 원문보기 2
 ScienceON
 
 KISS
Background: Sitagliptin is an antidiabetic drug that inhibits dipeptidyl peptidase-4 enzyme. This study aimed to investigate the antinociceptive and anti-inflammatory effects of sitagliptin in formalin and carrageenan tests and determine the possible mechanism(s) of its antinociceptive activity. Methods: Male Swiss mice (25-30 g) and male Wistar rats (180-220 g) were used for formalin and carrageenan tests, respectively. In the formalin test, paw licking time and in the carrageenan test, paw thickness were considered as indexes of pain behavior and inflammation respectively. Three doses of sitagliptin (2.5, 5, and 10 mg/kg) were used in these tests. Also, several antagonists and enzyme inhibitors were used to evaluate the role of adrenergic, serotonergic, dopaminergic, and opioid receptors as well as the NO/cGMP/KATP pathway in the antinociceptive effect of sitagliptin (5 mg/kg). Results: Sitagliptin showed significant antinociceptive and anti-inflammatory effects in the formalin and carrageenan tests respectively. In the carrageenan test, all three doses of sitagliptin significantly (P < 0.001) reduced paw thickness. Pretreatment with yohimbine, prazosin, propranolol, naloxone, and cyproheptadine could not reverse the antinociceptive effect of sitagliptin (5 mg/Kg), which indicates that adrenergic, opioid, and serotonin receptors (5HT2) are not involved in the antinociceptive effects. L-NAME, methylene blue, glibenclamide, ondansetron, and sulpiride were able to reverse this effect. Conclusions: NO/cGMP/KATP, 5HT3 and D2 pathways play an important role in the antinociceptive effect of sitagliptin. Additionally significant anti-inflammatory effects observed in the carrageenan test might contribute in reduction of pain response in the second phase of the formalin test.
3
An Investigation of the Analgesic and Anti-Inflammatory Effects of Nigella sativa Seed Polyphenols

Alireza Ghannadi,Valiollah Hajhashemi,Hadi Jafarabadi 한국식품영양과학회 2005 Journal of medicinal food Vol.8 No.4
Extracts obtained from the seeds of Nigella sativaare used as a spice or remedy for the treatment of variousinflammatory diseases. The purpose of this study was to examine the analgesic and anti-inflammatory effects of its polyphe-nols. N. sativaseed polyphenols were prepared, and analgesic and anti-inflammatory effects were studied in mice and rats us-ing the acetic acid-induced writhing, formalin, light tail flick, carrageenan-induced paw edema, and croton oil-induced earedema tests. In the acetic acid-induced writhing test, oral administration of N. sativa polyphenols (NSP) decreased the num-ber of abdominal constrictions. Both oral and intraperitoneal administration of NSP significantly suppressed in a dose-de-pendent manner the nociceptive response in the early and late phases of the formalin test, and the effect on the late phase wasmore pronounced. Pretreatment with naloxone failed to reverse the analgesic activity of NSP in this test. NSP did not pro-duce a significant analgesia in the light tail flick test in mice. Oral administration of NSP did not produce a significant re-duction in carrageenan-induced paw edema. However, when injected intraperitoneally, NSP inhibited paw edema in a dose-dependent manner. NSP when applied topically failed to reduce croton oil-induced ear edema. These results suggest that NSPhave analgesic and anti-inflammatory effects. The lack of analgesic effect of NSP in the light tail flick test and also the fail-ure of naloxone to reverse the analgesia in the formalin test reveal that mechanisms other than stimulation of opioid recep-tors are involved.