http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Vahid Alimardani (검색결과 1 건)
- 무료
- 기관 내 무료
- 유료
-
Vahid Alimardani,Samira Sadat Abolmaali,Gholamhossein Yousefi,Mohammad Hossein Nowroozzadeh,Ali Mohammad Tamaddon 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.119 No.-
Dissolving microneedles (dMNs) are proving to be attractive minimally invasive ophthalmic delivery systemsowing to their superior ability to deliver a variety of therapeutic agents through the cornea or sclera. Nevertheless, dMN formulation is most often complicated when poorly water-soluble drugs are used,because dMNs usually contain water-soluble polymers that dissolve quickly in ocular tissues. Here, wesynthesized the thermosensitive in-situ micelle-forming poly (N-isopropyl acrylamide)-b-poly (lglutamicacid) (PNIPAAm-b-PGA) copolymer which was soluble in organic and aqueous solvents, makingit possible to prepare MNs containing hydrophilic drugs. After full characterization of the copolymer, itwas successfully used to fabricate dMNs using the micro-molding technique. Remarkably, they generatedin-situ nanomicelles (NMCs) with sizes below 100 nm allowing for efficient dexamethasone (DEX) encapsulation. In this regard, the concentration of PNIPAAm-b-PGA copolymer was optimized to producemicroneedles with acceptable properties. A series of characteristics were assessed for microneedles,including mechanical and insertion properties, drug loading, in vitro release behavior, and in vitro permeation. Overall, the findings indicated that poly PNIPAAm-b-PGA copolymer is capable of self-assemblinginto NMCs and can significantly incorporate DEX as a hydrophobic drug, improving the trans-scleral DEX)permeation across the sclera, making it a promising system for treating posterior ocular diseases.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
