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RISS 인기검색어
- 검색키워드
- 저자 : V.I. Kalinin (검색결과 3 건)
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D.L. Aminin,I.G. Agafonova,V.I. Kalinin,A.S. Silchenko,S.A. Avilov,V.A. Stonik,P.D. Collin,C. Woodward 한국식품영양과학회 2008 Journal of medicinal food Vol.11 No.3
Frondoside A, a major triterpene glycoside from North Atlantic commercially harvested sea cucumber Cucumaria frondosa, possesses strong immunomodulatory properties in subtoxic doses. Frondoside A stimulates lysosomal activity of mouse macrophages in vivo at a maximal effective stimulatory dose of 0.2 μg per mouse and is maintained over 10 days. This glycoside also shows a 30% stimulation of lysosomal activity in mouse macrophages in vitro at concentrations of 0.1–0.38 μg/mL. Frondoside A enhances macrophage phagocytosis of the bacterium Staphylococcus aureus in vitro at a maximal effective concentration of 0.001 μg/mL. Frondoside A stimulates reactive oxygen species formation in macrophages in vitro at a maximal effective concentration of 0.001 μg/mL. Frondoside A stimulates an increase in the number of antibody plaque-forming cells (normally B-cells in spleen) in vivo with a maximal stimulatory effect at a concentration of 0.2 μg per mouse (stimulatory index, 1.86). Frondoside A has a weak effect upon immunoglobulin (Ig) M production after immunization with sheep erythrocytes in mice. Frondoside A does not stimulate Ig production in mice and does not significantly enhance the ovalbumin-stimulated IgM and IgG antibody levels in ovalbumin-immunized mice. Hence frondoside A is an immunostimulant of cell-based immunity including phagocytosis without a significant effect on amplification of humoral immune activity or adjuvant properties. Therefore, frondoside A may provide curative and/or preventive treatment options against diseases wherein a depleted immune status contributes to the pathological processes.
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Dmitry L. Aminin,Tatyana Y. Gorpenchenko,Viktor P. Bulgakov,Polina V. Andryjashchenko,Sergey A. Avilov,Vladimir I. Kalinin 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.6
Holothurian triterpene glycosides are known to possess multiple biological activities. Here we show that cucumarioside A_2-2 from the Far-Eastern edible holothurian Cucumaria japonica possesses potent immunomodulatory properties. The present studies were done to determine if cucumarioside A_2-2 would affect macrophage adhesion, spreading, and motility. Resident peritoneal macrophages, collected from BALB/c mice, were exposed in vitro to low concentrations of cucumarioside A_2-2 and compared with appropriate controls. Results indicate that 0.02 μg/mL cucumarioside A_2-2 significantly enhanced macrophage morphology parameters and behavior. The glycoside stimulated these parameters by increasing the number of cells with increased adhesion properties as well as the spreading reaction and motility velocity by at least almost twofold. The data are discussed in terms of possible mechanisms underlying the immunomodulatory properties of cucumarioside A_2-2.
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Nonlinear Phenomena in Multiferroic Nanocapacitors: Joule Heating and Electromechanical Effects
Kim, Yunseok,Kumar, Amit,Tselev, Alexander,Kravchenko, Ivan I.,Han, Hee,Vrejoiu, Ionela,Lee, Woo,Hesse, Dietrich,Alexe, Marin,Kalinin, Sergei V.,Jesse, Stephen American Chemical Society 2011 ACS NANO Vol.5 No.11
<P>We demonstrate an approach for probing nonlinear electromechanical responses in BiFeO<SUB>3</SUB> thin film nanocapacitors using half-harmonic band excitation piezoresponse force microscopy (PFM). Nonlinear PFM images of nanocapacitor arrays show clearly visible clusters of capacitors associated with variations of local leakage current through the BiFeO<SUB>3</SUB> film. Strain spectroscopy measurements and finite element modeling point to significance of the Joule heating and show that the thermal effects caused by the Joule heating can provide nontrivial contributions to the nonlinear electromechanical responses in ferroic nanostructures. This approach can be further extended to unambiguous mapping of electrostatic signal contributions to PFM and related techniques.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2011/ancac3.2011.5.issue-11/nn203342v/production/images/medium/nn-2011-03342v_0003.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nn203342v'>ACS Electronic Supporting Info</A></P>
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