SOME POINT ESTIMATES FOR THE SHAPE PARAMETERS OF EXPONENTIATED-WEIBULL FAMILY

UMESH SINGH,PRAMOD K. GUPTA,S. K. UPADHYAY 한국통계학회 2006 Journal of the Korean Statistical Society Vol.35 No.1

Maximum product of spacings estimator is proposed in this paper asa competent alternative of maximum likelihood estimator for the parame-ters of exponentiated-Weibull distribution, which does work even when themaximum likelihood estimator does not exist. In addition, a Bayes type esti-mator known as generalized maximum likelihood estimator is also obtainedfor both of the shape parameters of the aforesaid distribution. Though, theclosed form solutions for these proposed estimators do not exist yet thesecan be obtained by simple appropriate numerical techniques. The relativeperformances of estimators are compared on the basis of their relative riskeciencies obtained under symmetric and asymmetric losses. An examplebased on simulated data is considered for illustration.AMS 2000 subject classications.Primary 62F10, 62F15, 93B40; Secondary 65C10,62N99.Keywords. Maximum product of spacings estimators, generalized maximum likelihoodestimators, maximum likelihood estimator, squared error loss function, LINEX loss func-tion, relative risk eciency, non-informative prior.1. IntroductionThe data obtained from lifetime experiments are referred to as failure timedata and such failure time data, results from dierent lifetime experiments con-ducted under sophisticated controlled and complex environments, exhibit dier-ent ypes of failure rates, which are generally categorized as, constant, monotoneReceived November 2004; accepted December 2005.yThis work was supported by Senior Research Fellowship (S.R.F), funded by Council ofScientic and Industrial Research (C.S.I.R.), India.

GSTT1 Null Genotype Distribution in the Kumaun Region of Northern India

Bag, Arundhati,Upadhyay, Saloni,Jeena, Lalit M.,Pundir, Princi,Jyala, Narayan S. Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.1

Glutathione S-transferases (GSTs) constitute a multigene family of multifunctional phase II metabolic enzymes. GSTT1, an important member of this group has a wide range of substrates including carcinogens. Total homozygous deletion or null genotype resulting in total lack of enzyme activity exists in populations for this enzyme. Since the null genotype may contribute to lower detoxification of carcinogens, this genotype is expected to increase cancer risk. The frequency of the GSTT1 null genotype is known to vary significantly among populations. However, little is known about its distribution in the hilly Kumaun region of northern India. Therefore, in this study, we determined the prevalence of the GSTT1 null polymorphism in the Kumaun popilation by conducting duplex PCR in 365 voluntary healthy individuals. The GSTT1 null genotype was detected in 18.4% of the individuals. Since GSTs play significant role in xenobiotic metabolism, the present data on GSTT1 genotype distribution should contribute in understanding genetic association with cancer risk in this understudied population.

Influence of Physiological and Environmental Factors on Growth and Sporulation of an Antagonistic Strain of Trichoderma viride RSR 7 [ERRATUM]

Upadhyay, R.S,Jayaswal, R.K.,Singh, Rajesh,Lee, Youn-Su The Korean Society of Mycology 2003 Mycobiology Vol.31 No.2

Effects of photostrictive actuator and active control of flexible membrane structure

S.C. Gajbhiye,S. H. UPADHYAY,S.P. Harsha 국제구조공학회 2014 Smart Structures and Systems, An International Jou Vol.14 No.2

The purpose of this paper is to investigate the flexible structure of parabolic shell using photostrictive actuators. The analysis is made to know its dynamic behavior and light-induced control forces for coupled parabolic shell. The effects of an actuator location as well as membrane and bending components under the control action have been analyzed considering the approximate spherical model. The parabolic membrane shell accuracy is being mathematically approximated and validated comparing the light induced control forces using approximate equivalent spherical shell model. The parabolic shell with kapton smart material and photostrictive actuators has been used to formulate the governing equation in the transverse direction. The Kirchhoff-Love assumptions are used to obtain the governing equation of shell with actuator. The mechanical membrane forces and bending moments for parabolic thin shell with actuator is used to analyze the dynamic effect. The results show that membrane control action is much more significant than bending control action. Photostrictive actuators oriented along circumferential direction (actuator-2) can give better control effect than actuators placed along longitudinal direction (actuator-1). The slight difference is observed between spherical and parabolic shell for a surface with focal length to the diameter ratio of 1.00 or more than unity. Space applications often have the shape of parabolical shells or shell of revolution, due to their required focusing, aiming, or reflecting performance. The present approach is focused that photostrictive actuators can effectively control the vibration of parabolical membrane shell. Also, the actuator\'s location plays an important role in defining the control force.

Structure, Optical and Formaldehyde Sensing Properties of Co-Precipitated Fe-Doped WO3 Nanomaterials

S. B. Upadhyay,P.P. Sahay 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2015 NANO Vol.10 No.8

Co-precipitated undoped and Fe-doped WO3 nanomaterials have been investigated by X-ray diffraction, Raman spectroscopy and scanning electron microscopy in order to study the influence of Fe doping in their structural and morphological properties. The synthesized WO3 nanomaterials have been found to possess monoclinic structure having average crystallite sizes 15–20 nm. The diffuse reflectance spectroscopy shows the optical bandgap ~2.85 eV. The 1.8 at.% Fe-doped WO3 exhibits selective high response to formaldehyde over methanol, ethanol, propan-2-ol and acetone. It exhibits the maximum response (~80%) to formaldehyde at the operating temperature of 225℃ for 50 ppm concentration in air.

Effect of incorporation of soy protein isolate and inulin on quality characteristics and shelf-life of low–fat duck meat sausages

Moirangthem S.,Laskar S. K.,Das A.,Upadhyay S.,Hazarika R. A.,Mahanta J. D.,Sangtam H. M. 아세아·태평양축산학회 2022 Animal Bioscience Vol.35 No.8

Objective: Low fat duck meat sausages were prepared by replacing the fat in the formulations with soy protein isolate (SPI) and inulin to find the best formulation having superior shelflife without affecting its quality attributes. Methods: Four sausage mix formulations were prepared viz.control (0% SPI and inulin), T1 (2.5% inulin), T2 (2.5% SPI), and T3 (2.5% SPI+2.5% inulin) replacing duck fat as per the recipe. Five batches of duck meat sausages of each formulation were prepared, and the final products were evaluated for physico-chemical, organoleptic, and microbiological qualities. Results: The % moisture and crude protein content of the sausages revealed an increasing trend (p<0.01) from control to the treated formulations, while the % total ash contents were found to be non-significant (p>0.05). On the contrary, the per cent ether extract decreased significantly (p<0.01) from the control to the treated groups. In terms of calorie value, control samples exhibited the highest values with a significant (p<0.01) regression from control to treated formulation, respectively. The colour profile study (L, a*, b*) of the formulations were found to be non-significant. Texture profile study in terms of springiness, cohesiveness, chewiness, and resilience revealed no significant difference in all the treatment groups except the hardness scores, which revealed a significantly (p<0.01) increasing trend from control to the treated formulations. The total viable count showed a significant decrease in the treated groups. However, there was a significant increase in the bacterial load during the storage till day 15th. The total viable psychrophilic bacterial count showed a significant (p<0.01) increase in bacterial load from day 5th to 15th day of storage. Colititre counts were negative for all the formulations until the 15th day of storage. Conclusion: The present study results may conclude that duck meat sausages could be prepared satisfactorily by replacing duck fat with SPI and inulin at the rate of 2.5% of each with superior quality attributes. Objective: Low fat duck meat sausages were prepared by replacing the fat in the formulations with soy protein isolate (SPI) and inulin to find the best formulation having superior shelflife without affecting its quality attributes.Methods: Four sausage mix formulations were prepared viz.control (0% SPI and inulin), T₁ (2.5% inulin), T₂ (2.5% SPI), and T₃ (2.5% SPI+2.5% inulin) replacing duck fat as per the recipe. Five batches of duck meat sausages of each formulation were prepared, and the final products were evaluated for physico-chemical, organoleptic, and microbiological qualities.Results: The % moisture and crude protein content of the sausages revealed an increasing trend (p<0.01) from control to the treated formulations, while the % total ash contents were found to be non-significant (p>0.05). On the contrary, the per cent ether extract decreased significantly (p<0.01) from the control to the treated groups. In terms of calorie value, control samples exhibited the highest values with a significant (p<0.01) regression from control to treated formulation, respectively. The colour profile study (<i>L</i>, <i>a</i>*, <i>b</i>*) of the formulations were found to be non-significant. Texture profile study in terms of springiness, cohesiveness, chewiness, and resilience revealed no significant difference in all the treatment groups except the hardness scores, which revealed a significantly (p<0.01) increasing trend from control to the treated formulations. The total viable count showed a significant decrease in the treated groups. However, there was a significant increase in the bacterial load during the storage till day 15th. The total viable psychrophilic bacterial count showed a significant (p<0.01) increase in bacterial load from day 5th to 15th day of storage. Colititre counts were negative for all the formulations until the 15th day of storage.Conclusion: The present study results may conclude that duck meat sausages could be prepared satisfactorily by replacing duck fat with SPI and inulin at the rate of 2.5% of each with superior quality attributes.

Optimization of Process Parameters for Enhanced Production of Ranibizumab in Escherichia coli

Rucha S. Patil,Nidhi Upadhyay,Anurag S. Rathore 한국생물공학회 2023 Biotechnology and Bioprocess Engineering Vol.28 No.3

Escherichia coli based systems, are favoured hosts for recombinant protein expression. However, Low Fab expression and high production costs are major obstacles for manufacturers. To enhance process economics, an efficient, well-defined upstream process is crucial. This paper presents a systematic approach of process optimization for production of Fab fragment, ranibizumab. A two-step design of experiments (DOE) approach has been used. Six variables were examined: post-induction temperature, postinduction time, inducer concentration, agitation speed, media pH, and cell density at induction time (induction OD). These parameters were evaluated for their effect on biomass concentration, protein titre, impurity level, and light to heavy chain ratio. First, screening DOE with fractional factorial design was performed to shortlist important process parameters. Next, response surface study based on central composite design was conducted for identifying the operating range for the significant process parameters. Induction OD, inducer concentration, pH, and temperature were identified as significant parameters with their respective optima at 1.2 OD, 1 mM, 7.4 pH, and 35°C, respectively. Operating under these conditions resulted in formation of 0.051 g protein/g inclusion bodies, 4.99 g/L biomass concentration, and light chain to heavy chain equal expression ratio (LC:HC=0.98), with 8.2% impurity. Additionally, based on the predictions, we found that temperature, induction OD, and their interactions significantly affect the LC:HC ratio and impurity level, and need to be tightly controlled. This study has highlighted the importance of fine-tuning of physical parameters for production of Fab fragments and to control impurity expression in microbial host systems.

Effects of photostrictive actuator and active control of flexible membrane structure

Gajbhiye, S.C.,Upadhyay, S.H.,Harsha, S.P. Techno-Press 2014 Smart Structures and Systems, An International Jou Vol.14 No.2

The purpose of this paper is to investigate the flexible structure of parabolic shell using photostrictive actuators. The analysis is made to know its dynamic behavior and light-induced control forces for coupled parabolic shell. The effects of an actuator location as well as membrane and bending components under the control action have been analyzed considering the approximate spherical model. The parabolic membrane shell accuracy is being mathematically approximated and validated comparing the light induced control forces using approximate equivalent spherical shell model. The parabolic shell with kapton smart material and photostrictive actuators has been used to formulate the governing equation in the transverse direction. The Kirchhoff-Love assumptions are used to obtain the governing equation of shell with actuator. The mechanical membrane forces and bending moments for parabolic thin shell with actuator is used to analyze the dynamic effect. The results show that membrane control action is much more significant than bending control action. Photostrictive actuators oriented along circumferential direction (actuator-2) can give better control effect than actuators placed along longitudinal direction (actuator-1). The slight difference is observed between spherical and parabolic shell for a surface with focal length to the diameter ratio of 1.00 or more than unity. Space applications often have the shape of parabolical shells or shell of revolution, due to their required focusing, aiming, or reflecting performance. The present approach is focused that photostrictive actuators can effectively control the vibration of parabolical membrane shell. Also, the actuator's location plays an important role in defining the control force.

ON F-STRUCTURE MANIFOLD

Upadhyay, M.D.,Das, Lovejoy S.K. Department of Mathematics 1978 Kyungpook mathematical journal Vol.18 No.2

The first part of this paper is devoted to the study of F-structure satisfying: $F^K+(-)^{K+1}F=0$ and $F^W+(-)^{W+1}F{\neq}0$, for 1<W<K. The case when K is odd and K($${\geq_-}3$$) has been considered. In the later part some structures involving Lie-derivatives. exterior and co-derivatives have been studied.

Changes in Skin Temperature and Physiological Reactions in Murrah Buffalo During Solar Exposure in Summer

Das, S.K.,Upadhyay, R.C.,Madan, M.L. Asian Australasian Association of Animal Productio 1997 Animal Bioscience Vol.10 No.5

Six adult female Murrah buffaloes of about 12 years were exposed to solar radiation during summer when minimum and maximum ambient temperatures were 27.1 and $44.1^{\circ}C$, respectively. The skin surface temperature at forehead, middle pinna, neck, rump, foreleg, hind legs were recorded using non-contact temperature measuring instrument and respiration rate and rectal temperature were measured throughout the 24 hours starting from 6:30 AM. The diurnal fluctuations and temperature gradients have been reported for buffaloes. During summer when ambient temperature and solar radiation was maximum, adult buffaloes were not able to maintain their thermal balance even after increasing the pulmonary frequency 5 - 6 times. The changes in skin temperature at various sites indicate that the temperature of skin surface not only varies in relation to exposure but also due to water diffusion and evaporation.