Bone Metastasis from Gastric Cancer: The Incidence, Clinicopathological Features, and Influence on Survival

Turkoz, Fatma Paksoy,Solak, Mustafa,Kilickap, Saadettin,Ulas, Arife,Esbah, Onur,Oksuzoglu, Berna,Yalcin, Suayib The Korean Gastric Cancer Association 2014 Journal of gastric cancer Vol.14 No.3

Purpose: To evaluate the incidence, clinicopathological characteristics, treatment outcomes, prognostic factors, and survival of gastric cancer patients with bone metastases. Materials and Methods: Of 4,617 gastric cancer patients who were treated between 2001 and 2013, 176 patients with bone metastases were analyzed. Results: The incidence of bone metastasis was 3.8%. The most common histopathological subtype was adenocarcinoma (79%) with poor differentiation (60.8%). The median interval from the diagnosis to bone metastasis was 11 months. The median survival time after bone metastasis was 5.4 months. Factors that were associated with longer median survival times included the following: isolated bone metastasis (P=0.004), well-differentiated tumors (P=0.002), palliative chemotherapy (P=0.003), zoledronic acid treatment (P<0.001), no smoking history (P=0.007), and no metastatic gastric cancer at the time of diagnosis (P=0.01). On the other hand, high levels of lactate dehydrogenase (LDH) (hazard ratio [HR]: 1.86; P=0.015), carcinoembryonic antigen (CEA) (HR: 2.04; P=0.002), and carbohydrate antigen (CA) 19-9 (HR: 2.94; P<0.001) were associated with shorter survival times. In multivariate analysis, receiving zoledronic acid (P<0.001) and performance status (P=0.013) were independent prognostic factors. Conclusions: Smoking history, poor performance status, poorly differentiated adenocarcinoma, and high levels of LDH, CEA, and CA 19-9 were shown to be poor prognostic factors, while receiving chemotherapy and zoledronic acid were associated with prolonged survival in gastric cancer patients with bone metastases.

Evaluation of different enamel conditioning techniques for orthodontic bonding

Turkoz, Cagri,Ulusoy, Cagri The Korean Association Of Orthodontists 2012 대한치과교정학회지 Vol.42 No.1

Objective: The aim of this study was to compare the effects of different enamel conditioning techniques for bracket bonding. Methods: Ninety-one human premolars were randomly divided in six groups of 15 specimens each. The enamel surfaces of the teeth were etched with 35% orthophosphoric acid in Group 1, with a self-etching primer in Group 2, sandblasted in Group 3, sandblasted and etched with 35% orthophosphoric acid in Group 4, conditioned by Er:YAG laser in Group 5 and conditioned by Er:YAG laser and etched with 35% phosphoric acid gel respectively in Group 6. After enamel conditioning procedures, brackets were bonded and shear bonding test was performed. After debonding, adhesive remnant index scores were calculated for all groups. One tooth from each group were inspected by scanning electron microscope for evaluating the enamel surface characteristics. Results: The laser and acid etched group showed the highest mean shear bond strength (SBS) value ($13.61{\pm}1.14$ MPa) while sandblasted group yielded the lowest value ($3.12{\pm}0.61$ MPa). Conclusions: Although the SBS values were higher, the teeth in laser conditioned groups were highly damaged. Therefore, acid etching and self-etching techniques were found to be safer for orthodontic bracket bonding. Sandblasting method was found to generate inadequate bonding strength.

Bond strength of different bonding systems to the lingual surface enamel of mandibular incisors

Turkoz, Cagri,Tuncer, Burcu Balos,Ulusoy, Mehmet Cagri,Tuncer, Cumhur The Korean Association Of Orthodontists 2010 대한치과교정학회지 Vol.40 No.4

본 연구의 목적은 서로 다른 종류의 접착시스템과 법랑질 보호제 등이 설측 브라켓의 인장강도에 영향을 미치는지 알아보는데 있다. 75개의 발치된 하악 전치를 5개의 그룹으로 임의로 나눈 후 설측 브라켓을 부착하였다. Group 1은 Transbond XT를, Group 2는 Transbond XT와 함께 불소 유리레진(Ortho-coat)을 Group 3는 Transbond XT와 Chlorohexidine varnish (Cervitec Plus)를 Group 4는 광중합 접착제(Aegis Ortho)를 Group 5는 antimicrobial self-etching primer (Clearfil Protect Bond)을 사용하였다. 불소유리 레진이나 Chlorohexidine varnish의 사용유무는 접착력에 영향을 미치지 못하였다. Group 5이 다른 그룹에 비해 접착력과 접착제 잔류지수(adhesive remnant index, ARI)가 통계적으로 유의하게 높았다 (p < 0.001). 법랑질 보호제 적용 시 설측 브라켓의 접착력에 부정적인 영향을 미치지 못하였다. 이상의 결과로 이번에 사용한 제품들은 설측 교정치료 기간 동안 환자의 구강위생을 개선시킬 수 있어 환자와 술자에게 도움을 줄 수 있을 것이다. 그러나 에나멜 층이 얇은 경우 Clearfil Protect Bond의 과도한 접착강도에 대해 고려해야 할 것이다. Objective: The aim of this study was to determine whether different types of adhesive systems and enamel-protective agents will affect the tensile bond strength of lingual brackets. Methods: A total of 75 extracted mandibular incisors were randomly divided into 5 groups and lingual brackets were bonded. Group 1 specimens received Transbond XT (3M Unitek, Monrovia, CA, USA), Group 2 required the application of a fluoride-releasing resin (Ortho-coat, Pulpdent, Watertown, MA, USA) with Transbond XT, Group 3 specimens received a chlorhexidine varnish (Cervitec Plus, Ivoclar Vivadent, Schaan, Lichtenstein) with Transbond XT. In Group 4, a light-cured orthodontic adhesive (Aegis Ortho, Bosworth, Skokie, USA) was applied and in Group 5, an antimicrobial self-etching primer (Clearfil Protect Bond, Kuraray, Osaka, Japan) was used. Results: There were no significant differences in bond strength whether fluoride-releasing resin or chlorhexidine varnish were used or not. Group 5 had significantly higher bond strength and adhesive remnant index (ARI) values than other groups (p < 0.001). The application of enamel-protective products did not have an adverse affect on the bond strength of lingual brackets. Conclusions: These products might provide benefits both for the patient and the clinician, by supporting the oral hygiene during lingual orthodontic treatment. The higher ARI score may be beneficial for Clearfil Protect Bond but its excessive bond strength should be considered in clinical practice, especially where the enamel is thin.

Evaluation of different enamel conditioning techniques for orthodontic bonding

Cagrı Turkoz,Cagrı Ulusoy 대한치과교정학회 2012 대한치과교정학회지 Vol.42 No.1

Objective: The aim of this study was to compare the effects of different enamel conditioning techniques for bracket bonding. Methods: Ninety-one human premolars were randomly divided in six groups of 15 specimens each. The enamel surfaces of the teeth were etched with 35% orthophosphoric acid in Group 1, with a self-etching primer in Group 2, sandblasted in Group 3, sandblasted and etched with 35% orthophosphoric acid in Group 4, conditioned by Er:YAG laser in Group 5 and conditioned by Er:YAG laser and etched with 35% phosphoric acid gel respectively in Group 6. After enamel conditioning procedures, brackets were bonded and shear bonding test was performed. After debonding, adhesive remnant index scores were calculated for all groups. One tooth from each group were inspected by scanning electron microscope for evaluating the enamel surface characteristics. Results: The laser and acid etched group showed the highest mean shear bond strength (SBS) value (13.61 ± 1.14 MPa) while sandblasted group yielded the lowest value (3.12 ± 0.61 MPa). Conclusions: Although the SBS values were higher, the teeth in laser conditioned groups were highly damaged. Therefore, acid etching and self-etching techniques were found to be safer for orthodontic bracket bonding. Sandblasting method was found to generate inadequate bonding strength.

Bone Metastasis from Gastric Cancer: The Incidence, Clinicopathological Features, and Influence on Survival

Fatma Paksoy Turkoz,Mustafa Solak,Saadettin Kilickap,Arife Ulas,Onur Esbah,Berna Oksuzoglu,Suayib Yalcin 대한위암학회 2014 Journal of gastric cancer Vol.14 No.3

Purpose: To evaluate the incidence, clinicopathological characteristics, treatment outcomes, prognostic factors, and survival of gastriccancer patients with bone metastases. Materials and Methods: Of 4,617 gastric cancer patients who were treated between 2001 and 2013, 176 patients with bone metastaseswere analyzed. Results: The incidence of bone metastasis was 3.8%. The most common histopathological subtype was adenocarcinoma (79%) withpoor differentiation (60.8%). The median interval from the diagnosis to bone metastasis was 11 months. The median survival time afterbone metastasis was 5.4 months. Factors that were associated with longer median survival times included the following: isolated bonemetastasis (P=0.004), well-differentiated tumors (P=0.002), palliative chemotherapy (P=0.003), zoledronic acid treatment (P<0.001),no smoking history (P=0.007), and no metastatic gastric cancer at the time of diagnosis (P=0.01). On the other hand, high levels oflactate dehydrogenase (LDH) (hazard ratio [HR]: 1.86; P=0.015), carcinoembryonic antigen (CEA) (HR: 2.04; P=0.002), and carbohydrateantigen (CA) 19-9 (HR: 2.94; P<0.001) were associated with shorter survival times. In multivariate analysis, receiving zoledronicacid (P<0.001) and performance status (P=0.013) were independent prognostic factors. Conclusions: Smoking history, poor performance status, poorly differentiated adenocarcinoma, and high levels of LDH, CEA, and CA19-9 were shown to be poor prognostic factors, while receiving chemotherapy and zoledronic acid were associated with prolonged survivalin gastric cancer patients with bone metastases.

Metaplastic Breast Carcinoma: Case Series and Review of the Literature

Esbah, Onur,Turkoz, Fatma P.,Turker, Ibrahim,Durnali, Ayse,Ekinci, Ahmet S.,Bal, Oznur,Sonmez, Ozlem Uysal,Budakoglu, Burcin,Arslan, Ulku Y.,Oksuzoglu, Berna Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.9

Metaplastic breast carcinoma (MpBC) is a rare disease entity, accounting for less than 1% of all breast carcinomas. Furthermore, it is a heterogenous disease with different subgroups, including malignant epithelial (carcinoma) and stromal (sarcoma) features. Here we evaluated, retrospectively, 14 female MpBC patients admitted to Ankara Oncology Training and Research Hospital between 2005 and 2011. Median age was 45.5 (range:16.0-76.0) and tumor size 57.5 mm (range: 20.0-80.0 mm). Histopathological subtypes were as follows: 5 carcinosarcoma, 5 squamous and 4 adenosquamous carcinoma. All but one with upfront lung metastasis, had their primary breast tumor operated. Axillary lymph nodes were involved in 64.3%. The most common sites of metastasis were lungs and brain. Chemotherapy including antracycline, taxane and even platinium was planned for adjuvant, neoadjuvant and palliative purposes in 9, 3 and 1 patient, respectively. Median cycles of chemotherapy was 6 (range:4-8). Median follow-up of the patients was 52 months (95%CI 10.4-93.6 month). Median 3 year progression free survival (PFS) and overall survival (OS) in this patients cohort were 33% and 56%, respectively. In conclusion, MpBC is a rare and orphan disease without standardized treatment approaches and the prognosis is poor so that larger studies to investigate different treatment schedules are urgently needed.

New multi-stage similarity measure for calculation of pairwise patent similarity in a patent citation network

Rodriguez, Andrew,Kim, Byunghoon,Turkoz, Mehmet,Lee, Jae-Min,Coh, Byoung-Youl,Jeong, Myong K. Springer-Verlag 2015 Scientometrics Vol.103 No.2

The Effect of Agoraphobia on Oxidative Stress in Panic Disorder

Isil Gogcegoz Gul,Rifat Karlidag,Birgul Elbozan Cumurcu,Yusuf Turkoz,Sukru Kartalci,A. Cemal Ozcan,M. Erman Erdemli 대한신경정신의학회 2013 PSYCHIATRY INVESTIGATION Vol.10 No.4

We aimed to investigate whether agoraphobia (A) in panic disorder (PD) has any effects on oxidative and anti-oxidative parameters. We measured total antioxidant capacity (TAC), paraoxonase (PON), arylesterase (ARE) antioxidant and malondialdehyde (MDA) oxidant levels using blood samples from a total of 31 PD patients with A, 22 PD patients without A and 53 control group subjects. There was a significant difference between the TAC, PON, ARE and MDA levels of the three groups consisting of PD with A, PD without A and the control group. The two-way comparison to clarify the group creating the difference showed that the TAC, PON, and ARE antioxidants were significantly lower in the PD with A group compared to the control group while the MDA oxidant was significantly higher. There was no significant difference between the PD without A and control groups for TAC, PON, ARE and MDA levels. We clearly demonstrated that the oxidative stress and damage to the anti-oxidative mechanism are significantly higher in the PD group with A. These findings suggest that oxidative/anti-oxidative mechanisms may play a more important role on the pathogenesis of PB with A.