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      • KCI등재

        Statistical Analysis of Truck Accidents for Divided Multilane Interurban Roads in Turkey

        Funda Ture Kibar,Fazil Celik,Bengi P. Aytac 대한토목학회 2018 KSCE JOURNAL OF CIVIL ENGINEERING Vol.22 No.5

        Freight transportation is an important factor in Turkish economic growth, and the high volume of truck traffic has increased trafficaccidents on Turkish roads. However, to the best of our knowledge, no studies have investigated the factors that contribute to truckaccidents. This study aims to reduce truck accident involvement and quantify the effect of variables on the occurrence of truckaccidents on divided multilane interurban roads in Turkey. This study documents the performance of Poisson, Negative Binomial(NB), and Zero-inflated Negative Binomial Regression (ZINB) models to establish the relation between truck accidents and trafficand geometric road characteristics on a 282 km section of the Ankara–Aksaray–Eregli divided multilane interurban road. Modelcoefficients were estimated by the maximum likelihood method, and deviance and the Akaike information criterion were consideredas goodness of fit statistics. The Vuong test was used to determine the appropriateness of using the ZINB model rather than the NBmodel. The results show that the NB model fitted the data very well. The proposed model for Turkish divided multilane interurbanroads with a high percentage of truck traffic might be useful to detect critical factors and reduce truck accident involvement.

      • KCI등재

        Free to Develop?

        John A. Tures 서울대학교 국제학연구소 2005 Journal of International and Area Studies Vol.12 No.2

        Academics have long debated whether relationship exists between freedom and development. Problems with these studies lead others to question the connection between these variables. In contributing to the scholarly debate, a new interactive variable is created that combines several measures of economic and political freedom, as suggested by Milton Friedman. The link between this new freedom variable and both economic and human development is examined across a series of cross-sections from the 1970s, 1980s and 1990s. Results indicate that this new freedom measure is strongly related to both forms of development for the developed and developing world.

      • KCI등재

        Free to Develop?

        John A,Tures 서울대학교 국제학연구소 2005 Journal of International and Area Studies Vol.12 No.2

          Academics have long debated whether relationship exists between freedom and development. Problems with these studies lead others to question the connection between these variables. In contributing to the scholarly debate, a new interactive variable is created that combines several measures of economic and political freedom. as suggested by Milton Friedman. The link between this new freedom variable and both economic and human development is examined across a series of cross-sections from the 1970s, 1980s and 1990s. Results indicate that this new freedom measure is strongly related to both forms of development for the developed and developing world.

      • SCOPUS

        Optimization of the photo-Fenton-like process for real and synthetic azo dye production wastewater treatment using response surface methodology

        Arslan-Alaton, Idil,Tureli, Gokce,Olmez-Hanci, Tugba Korean Society of Photoscience 2009 Photochemical & photobiological sciences Vol.8 No.5

        Treatability of synthetic Acid Blue 193 and Reactive Black 39 production wastewaters and real Reactive Black 39 production effluent via photo-Fenton-like process was investigated. The Central Composite Design technique was used to study the effect of some critical process parameters of the photo-Fenton process (e.g. reaction time, initial COD and $Fe^{3+}$ : $H_2O_2$ molar ratio) on synthetic Acid Blue 193 production wastewater treatment efficiency in terms of color, chemical oxygen demand (COD) and total organic carbon (TOC) removals. Selected process parameters were optimized to obtain maximum color, COD and TOC removal efficiencies. Optimum working conditions were established as 45 min reaction time and a $Fe^{3+}$ : $H_2O_2$ molar ratio of 0.073 for wastewater having an initial COD ($COD_o$) of $200\;mg\;L^{-1}$. Under these conditions, 99% color, 83% COD and 58% TOC abatements were experimentally obtained. In case of real Reactive Black 39 production effluent, photo-Fenton-like treatment efficiency was found to be considerably lower than that of the synthetic acid and reactive dye production wastewaters, which was attributable to the relatively high chloride (i.e. a well known $^{\cdot}OH$ radical scavenger) content of the real effluent.

      • MMP2 Gene-735 C/T and MMP9 gene -1562 C/T Polymorphisms in JAK2V617F Positive Myeloproliferative Disorders

        Sag, Sebnem Ozemri,Gorukmez, Ozlem,Ture, Mehmet,Gorukmez, Orhan,Topak, Ali,Sahinturk, Serdar,Ocakoglu, Gokhan,Gulten, Tuna,Ali, Ridvan,Yakut, Tahsin Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.2

        Background: Myeloproliferative disorders (MPDs) are clonal hematologic malignancies originating at the level of the pluripotent hematopoietic stem cell. Matrix metalloproteases (MMPs) are proteolytic enzymes that contribute to all stages of malignancy progression. Genetic variants in the MMP genes may influence the biological function of these enzymes and change their role in carcinogenesis and progression. To our knowledge, this is the first investigation of associations between the -735 C/T and -1562 C/T polymorphisms in the MMP2 and MMP9 genes, respectively, and the risk of essential thrombocytosis (ET), and polycythemia vera (PV). Materials and Methods: The case-control study included JAK2V617F mutation positive 102 ET and PV patients and 111 controls. Polymorphisms were determined by using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and electrophoresis. Results: No statistically significant differences were detected between patient (ET+PV) and control groups regarding genotype distribution for MMP2 gene-735 C/T and MMP9 gene -1562 C/T polymorphisms and C/T allele frequency (p>0.050). Statistically borderline significance was observed between PV and control groups regarding genotype distribution for the MMP9 gene -1562 C/T polymorphism (p=0.050, OR=2.26, 95%Cl=0.99-5.16). Conclusions: Consequently this study supported that CC genotype of MMP9 gene -1562 C/T polymorphism may be related with PV even if with borderline significance.

      • KCI등재

        Bacteremia in Hematopoietic Stem Cell Recipients Receiving Fluoroquinolone Prophylaxis: Incidence, Resistance, and Risk Factors

        Eryilmaz-Eren Esma,Izci Feyza,Ture Zeynep,Sagiroglu Pinar,Kaynar Leylagul,Ulu-Kilic Aysegul 대한감염학회 2022 Infection and Chemotherapy Vol.54 No.3

        Background Bacteremia is a common complication in hematopoietic stem cell transplant (HSCT) recipients. Prophylactic fluoroquinolone is recommended and used in these individuals. Breakthrough infections can occur with fluoroquinolone-resistant strains. We aimed to identify the incidence, resistance, and risk factors for bacteremia in HSCT recipients receiving fluoroquinolone prophylaxis. Materials and Methods This retrospective study was performed on patients who received fluoroquinolone prophylaxis and underwent autologous and allogeneic HSCT between 2015 and 2019. The incidence of bacteremia, comorbidity, treatment, and invasive procedures was compared in these patients with and without bacteremia. Results There were 553 patients included in the study, 68 (12.3%) had bacteremia. The incidence of bacteremia is 8.2% of autologous HSCT recipients and 18.4% of allogeneic HSCT recipients. The significant risk factors associated with bacteremia were steroid-using (odds ratio [OR]:13.83, 95% confidence interval [CI]: 2.88 - 66.40), higher Charlson Comorbidity Index (CCI)-mean (OR: 1.57, 95% CI: 1.15 - 2.16), diabetes mellitus (OR: 4.29, 95% CI: 1.11 - 16.48) in autologous HSCT, steroid-using (OR: 6.84, 95% CI: 1.44 - 32.33), longer duration of neutropenia (OR: 1.05, 95% CI: 1.01 - 1.09) using central venous catheter (OR: 7.81, 95% CI: 1.00 - 61.23) in allogeneic HSCT. Seventy-three pathogens were isolated from a total of 68 bacteremia episodes. The most commonly occurring agents were Escherichia coli, Klebsiella pneumoniae and Enterococcus spp. Resistance to fluoroquinolones was 87.2%, 70.0% and 60.0% among these strains, respectively. Conclusion High CCI, diabetes mellitus, use of steroids and long-term neutropenia and use of central venous catheters were significantly associated with the breakthrough bacteremia in HSCT recipients receiving fluoroquinolone prophylaxis. Fluoroquinolone prophylaxis may reduce the incidence of bacteremia but may select strains resistant to fluoroquinolone. Background Bacteremia is a common complication in hematopoietic stem cell transplant (HSCT) recipients. Prophylactic fluoroquinolone is recommended and used in these individuals. Breakthrough infections can occur with fluoroquinolone-resistant strains. We aimed to identify the incidence, resistance, and risk factors for bacteremia in HSCT recipients receiving fluoroquinolone prophylaxis. Materials and Methods This retrospective study was performed on patients who received fluoroquinolone prophylaxis and underwent autologous and allogeneic HSCT between 2015 and 2019. The incidence of bacteremia, comorbidity, treatment, and invasive procedures was compared in these patients with and without bacteremia. Results There were 553 patients included in the study, 68 (12.3%) had bacteremia. The incidence of bacteremia is 8.2% of autologous HSCT recipients and 18.4% of allogeneic HSCT recipients. The significant risk factors associated with bacteremia were steroid-using (odds ratio [OR]:13.83, 95% confidence interval [CI]: 2.88 - 66.40), higher Charlson Comorbidity Index (CCI)-mean (OR: 1.57, 95% CI: 1.15 - 2.16), diabetes mellitus (OR: 4.29, 95% CI: 1.11 - 16.48) in autologous HSCT, steroid-using (OR: 6.84, 95% CI: 1.44 - 32.33), longer duration of neutropenia (OR: 1.05, 95% CI: 1.01 - 1.09) using central venous catheter (OR: 7.81, 95% CI: 1.00 - 61.23) in allogeneic HSCT. Seventy-three pathogens were isolated from a total of 68 bacteremia episodes. The most commonly occurring agents were Escherichia coli, Klebsiella pneumoniae and Enterococcus spp. Resistance to fluoroquinolones was 87.2%, 70.0% and 60.0% among these strains, respectively. Conclusion High CCI, diabetes mellitus, use of steroids and long-term neutropenia and use of central venous catheters were significantly associated with the breakthrough bacteremia in HSCT recipients receiving fluoroquinolone prophylaxis. Fluoroquinolone prophylaxis may reduce the incidence of bacteremia but may select strains resistant to fluoroquinolone.

      • KCI등재후보

        GST (GSTM1, GSTT1, and GSTP1) polymorphisms in the genetic susceptibility of Turkish patients to cervical cancer

        Beray Kiran,Mutlu Karkucak,Tahsin Yakut,Kemal Ozerkan,Sebnem Sag,Mehmet Ture 대한부인종양학회 2010 Journal of Gynecologic Oncology Vol.21 No.3

        Objective: This work investigates the role of glutathione S-transferase M1 (GSTM1), glutathione S-transferase T1(GSTT1), and glutathione S-transferase P1 (GSTP1) enzymes and polymorphisms, which are found in phase II detoxification reactions in the development of cervical cancer. Methods: This study was conducted with 46 patients diagnosed with cervical cancer and 52 people with no cancer history. Multiplex PCR methods were used to evaluate the GSTM1 and GSTT1 gene polymorphism. However, the GSTP1 (Ile105Val) gene polymorphism was studied using a PCR-RFLP method. The patient and control groups were compared using a chi-square test with p<0.05. Results: In the patient group, statistical significance was determined for gravidity (p=0.03), parity (p=0.01), and the number of living children (p=0.01) compared to the control group. The gene frequency of GSTM1, GSTT1, and GSTP1polymorphisms was evaluated. We observed that GSTM1 and GSTT1 null genotype frequencies were 54.3% and 32.6%respectively, while GSTP1 (Ile/Val), (Ile/Ile), (Val/Val) genotype frequencies were 52%, 44%, and 4%, respectively, in the cervical cancer patients. No statistical variation was determined between the control and patient groups in terms of GSTM1, GSTT1, and GSTP1 polymorphisms (p>0.05). Conclusion: Our results demonstrate that GSTT1, GSTM1, and GSTP1 polymorphisms are not associated with cervical cancer in Turkish patients.

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