MuBike : Cloud Communication Service Composition Platform for Automatic Renting Bikes

Yen-Chiu Chen,Tse-Shih Chen,Hui-Ching Hsieh,Tai-Hua Hsiao 보안공학연구지원센터(IJUNESST) 2014 International Journal of u- and e- Service, Scienc Vol.7 No.4

Ligand-Receptor Recognition for Activation of Quorum Sensing in Staphylococcus aureus

Li-Chun Chen,Li-Tse Tsou,Feng-Jui Chen 한국미생물학회 2009 The journal of microbiology Vol.47 No.5

The accessory gene regulator (agr) locus controls many of the virulence toxins involved in Staphylococcus aureus pathogenesis, and can be divided into four specificity groups. AgrC is the only group-specific receptor to mediate both intra-group activation and inter-group inhibition. We studied the ligand-receptor recognition of the agr system in depth by using a luciferase reporter system to identify the key residues responsible for AgrC activation in two closely related agr groups, AgrC-I, and AgrC-IV. Fusion PCR and site-directed mutagenesis were used to screen for functional residues of AgrC. Our data suggest that for AgrC-IV activation, residue 101 is critical for activating the receptor. In contrast, the key residues for the activation of AgrC-I are located at residues 49~59, 107, and 116. However, three residue changes, T101A, V107S, I116S, are sufficient to convert the AIP recognizing specificity from AgrC-IV to AgrC-I.

Prognostic Factors in Adult Patients with Solid Cancers and Bone Marrow Metastases

Hung, Yu-Shin,Chou, Wen-Chi,Chen, Tai-Di,Chen, Tse-Ching,Wang, Po-Nan,Chang, Hung,Hsu, Hung-Chih,Shen, Wen-Chi,Cheng, Wei-Hong,Chen, Jen-Shi Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.1

Background: Solid cancers with bone marrow metastases are rare but lethal. This study aimed to identify clinical factors predictive of survival in adult patients with solid cancers and bone marrow metastases. Methods: A total of 83 patients were enrolled consecutively between January 1, 2000 and December 31, 2012. Bone marrow metastases were confirmed by biopsies. Patient clinical features and laboratory data were analyzed for associations. Results: The median age of the patients was 54 years (range, 23-88 years), and 58% were male. The 3 most common primary tumor locations were the stomach (32 patients, 39%), prostate (16 patients, 19%), and lungs (12 patients, 15%). The median overall survival was 49 days (range, 3-1423 days). Patients with Eastern Cooperative Oncology Group performance status 1, cancers of prostate origin, platelet counts over 50,000/ml, and undergoing antitumor therapies had a significantly better prognosis in the multivariate analysis. The median survival times were 173 and 33 days for patients with 2-3 more favorable parameters (n=24) and those with 0-1 (n=69), respectively (hazard ratio 0.30; 95% CI 0.17-0.52, p<0.001). Conclusions: Solid cancers with bone marrow metastases are dismal and incurable diseases. Understanding prognostic factors to these diseases helps medical personnel to provide appropriate treatments and better inform patients about outcomes. Antitumor therapies may improve outcomes in selected patient cohorts.

Chloride Ion Sensor Using Polyaniline Modified Carbon Electrode Prepared With and Without Ultrasonic Irradiation

Chen, Cai-Lun,Chou, Tse-Chuan 경북대학교 센서기술연구소 1998 센서技術學術大會論文集 Vol.9 No.1

Chloride ion sensor has a great deal of interest due to its importance in analyzing chloride ion in many areas, such as foods, drugs, biochemical studies and environmental pollution controls. The polyaniline modified carbon electrodes prepared by cyclic voltammograms with and without ultrasonic irradiation were used to detect chloride ion. The results showed that the response time, sensitivity and stability of chloride ion sensor prepared without ultrasonic irradiation were poor. On the other hand, the sensing characteristics of chloride ion sensor prepared with ultrasonic irradiation were good. The interference of other ions was also tested.

Investigation of flow visualization around linked tall buildings with circular sections

Kim, Bubryur,Tse, K.T.,Yoshida, Akihito,Chen, Zengshun,Van Phuc, Pham,Park, Hyo Seon Elsevier 2019 Building and environment Vol.153 No.-

<P><B>Abstract</B></P> <P>This study investigated the wind environment around buildings by visualizing the wind flow patterns of linked buildings (LB), in which two buildings with circular sections are attached through linking members. Particle image velocimetry was used to measure the wind flows around LB models with different gap distances between the buildings. Proper orthogonal decomposition (POD) analysis was applied to identify velocity and vorticity patterns. The results showed that when the two buildings have a side-by-side arrangement ( α = <SUP> 0 o </SUP> ), and the gap distance is small, the POD using velocity indicates a single vortex street and biased flow in the gap, whereas that using vorticity suggests a contracted flow in the gap. When the gap distance is large, two independent vortex streets appear in the first mode of both POD, with the POD using vorticity confirming the presence of recirculation zones in the wake region. In a tandem arrangement ( α = <SUP> 90 o </SUP> ), the shear layer street occurring in the upstream building affects the entire LB system, and the POD analysis using vorticity shows that the shear layer cannot surround the downstream building if the gap distance is large. The link, gap distance, and elevation have little impact on the flow patterns when α = <SUP> 90 o </SUP> . However, these factors affect the flow patterns when α = <SUP> 0 o </SUP> . In addition, when the gap distance is equal to two-thirds of the building breadth and α = <SUP> 0 o </SUP> , the two shear layer streets joined behind the space between the two buildings and produced the maximum mean wind speed around the building compared to other cases.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The wind flow patterns around linked building systems were investigated. </LI> <LI> Various wind flows occur in two buildings with a side-by-side arrangement. </LI> <LI> Wind flows in two buildings with a tandem arrangement are less diverse than others. </LI> <LI> Biased flow, contraction flow, and shear layer depend on the gap distance. </LI> <LI> The upstream building affects the downstream building at certain gap distances. </LI> </UL> </P>

Pressure measurements on inclined square prisms

Hu, Gang,Tse, K.T.,Kwok, K.C.S.,Chen, Z.S. Techno-Press 2015 Wind and Structures, An International Journal (WAS Vol.21 No.4

This study investigated aerodynamic characteristics of an inclined square prism experimentally. Pressure measurements were performed on a static square prism with a series of inclinations including forward inclinations (inclined to the upwind direction) and backward inclinations (inclined to the downwind direction). The prism with a vertical attitude was also tested for comparisons. Based on the pressure data, influences of the inclinations on aerodynamic characteristics (e.g., force coefficients, pressure distributions on the surfaces, and vortex shedding features) of the square prism were evaluated in detail. The results show that the inclinations have significant effects on these aerodynamic characteristics. Furthermore, the influences of the forward and backward inclinations are quite different.

Effect of aerodynamic modifications on the surface pressure patterns of buildings using proper orthogonal decomposition

K.T. Tse,Zeng-shun Chen,Dong-Eun Lee,Bubryur Kim 한국풍공학회 2021 Wind and Structures, An International Journal (WAS Vol.32 No.3

This study analyzed the pressure patterns and local pressure of tall buildings with corner modifications (recessed and chamfered corner) using wind tunnel tests and proper orthogonal decomposition (POD). POD can distinguish pressure patterns by POD mode and more dominant pressure patterns can be found according to the order of POD modes. Results show that both recessed and chamfered corners effectively reduced wind-induced responses. Additionally, unique effects were observed depending on the ratio of corner modification. Tall building models with recessed corners showed fluctuations in the approaching wind flow in the first POD mode and vortex shedding effects in the second POD mode. With large corner modification, energy distribution became small in the first POD mode, which shows that the effect of the first POD mode reduced. Among building models with chamfered corners, vortex shedding effects appeared in the first POD mode, except for the model with the highest ratio of corner modifications. The POD confirmed that both recessed and chamfered corners play a role in reducing vortex shedding effects, and the normalized power spectral density peak value of modes showing vortex shedding was smaller than that of the building model with a square section. Vortex shedding effects were observed on the front corner surfaces resulting from corner modification, as with the side surface. For buildings with recessed corners, the local pressure on corner surfaces was larger than that of side surfaces. Moreover, the average wind pressure was effectively reduced to 88.42% and 92.40% in RE1 on the windward surface and CH1 on the side surface, respectively.

Improvement of Zinc Coating Weight Control for Transition of Target Change

( Chien Ming Chen ),( Jeng Hwa Lin ),( Tse Wei Hsu ),( Rui Rong Lin ) 한국부식방식학회(구 한국부식학회) 2010 Corrosion Science and Technology Vol.9 No.3

A Method for Identifying Tubercle Bacilli using Neural Networks

Lin, Sheng-Fuu,Chen, Hsien-Tse The Korean Society of Medical and Biological Engin 2009 의공학회지 Vol.30 No.3

Phlegm smear testing for acid-fast bacilli (AFB) requires careful examination of tubercle bacilli under a microscope to distinguish between positive and negative findings. The biggest weakness of this method is the visual limitations of the examiners. It is also time-consuming, and mistakes may easily occur. This paper proposes a method of identifying tubercle bacilli that uses a computer instead of a human. To address the challenges of AFB testing, this study designs and investigates image systems that can be used to identify tubercle bacilli. The proposed system uses an electronic microscope to capture digital images that are then processed through feature extraction, image segmentation, image recognition, and neural networks to analyze tubercle bacilli. The proposed system can detect the amount of tubercle bacilli and find their locations. This paper analyzes 184 tubercle bacilli images. Fifty images are used to train the artificial neural network, and the rest are used for testing. The proposed system has a 95.6% successful identification rate, and only takes 0.8 seconds to identify an image.

A High-Efficiency High Step-Up Interleaved Converter with a Voltage Multiplier for Electric Vehicle Power Management Applications

Kuo-Ching Tseng,Chun-Tse Chen,Chun-An Cheng 전력전자학회 2016 JOURNAL OF POWER ELECTRONICS Vol.16 No.2

This paper proposes a novel high-efficiency high-step-up interleaved converter with a voltage multiplier, which is suitable for electric vehicle power management applications. The proposed interleaved converter is capable of achieving high step-up conversion by employing a voltage-multiplier circuit. The proposed converter lowers the input-current ripple, which can extend the input source"s lifetime, and reduces the voltage stress on the main switches. Hence, large voltage spikes across the main switches are alleviated and the efficiency is improved. Finally, a prototype circuit with an input voltage of 24 V, an output voltage of 380 V, and an output rated power of 1 kW is implemented and tested to demonstrate the functionality of the proposed converter. Moreover, satisfying experimental results are obtained and discussed in this paper. The measured full-load efficiency is 95.2%, and the highest measured efficiency of the proposed converter is 96.3%.