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( Trang An Duong ),( Hoang Thien Khoi Nguyen ),( Sang-sub Lee ),( Chang Won Ahn ),( Byeong Woo Kim ),( Jae Shin Lee ),( Hyoung Su Han ) 한국센서학회 2021 센서학회지 Vol.30 No.6
This study analyzes the phase transition behavior and electrical properties of lead-free (1-x)K<sub>0.5</sub>Na<sub>0.5</sub>NbO<sub>3-x</sub>BaZrO<sub>3</sub> (KNN-100xBZ) piezoelectric ceramics. The stabilized crystal structures in BaZrO<sub>3</sub>-modified KNN ceramics is clarified to be pseudocubic. The polymorphic phase transition from the orthorhombic to pseudocubic phases can be observed with KNN-6BZ ceramics considering the optimized piezoelectric constant (d<sub>33</sub>). Electromechanical strain behaviors are discussed. Accordingly, the enhancement of strain value at x = 0.08 (composition) may originate from the coexistence of ferroelectric domains and polar nanoregions. A schematic of domains for KNN, KNN-8BZ, and KNN-15BZ ceramics has been proposed to describe the relationship between the stabilized relaxor and changes in electrical properties.
Duong, Huu Thuy Trang,Thambi, Thavasyappan,Yin, Yue,Kim, Seong Han,Nguyen, Thanh Loc,Phan, V.H. Giang,Kim, Jaeyun,Jeong, Ji Hoon,Lee, Doo Sung Elsevier 2020 Biomaterials Vol.230 No.-
<P><B>Abstract</B></P> <P>Cancer vaccines that elicit a robust and durable antitumor response show great promise in cancer immunotherapy. Nevertheless, low immunogenicity and weak immune response limit the application of cancer vaccines. To experience next generation cancer vaccines that elicit robust, durable, and anti-tumor T cell response, herein we design injectable smart hydrogels (ISHs) that self-assemble into a cellular microenvironment-like microporous network using a simple hypodermic needle injection, to localize the immune cells and program host cells. ISHs, composed of levodopa- and poly(ε-caprolactone-<I>co</I>-lactide)ester-functionalized hyaluronic acid (HA-PCLA), are loaded with immunomodulatory factor (OVA expressing plasmid, pOVA)-bearing nano-sized polyplexes and granulocyte-macrophage colony-stimulating factor (GM-CSF) as dendritic cell (DC) enhancement factor. Subcutaneous administration of ISHs effectively localized immune cells, and controlled the delivery of immunomodulatory factors to recruit immune cells. The microporous network allowed the recruitment of a substantial number of DCs, which was 6-fold higher than conventional PCLA counterpart. The locally released nano-sized polyplexes effectively internalized to DCs, resulting in the presentation of tumor-specific OVA epitope, and subsequent activation of CD4<SUP>+</SUP> T cells and generation of OVA-specific serum antibody. By the controlled release of nano-sized polyplexes and GM-CSF through a single subcutaneous injection, the ISHs effectively eliminated B16/OVA melanoma tumors in mice. These ISHs can be administered using a minimal invasive technique that could bypass the need for extracorporeal training of cells <I>ex vivo</I>, and provide sustained release of cancer vaccines for immunomodulation. These important findings suggest that ISHs can serve as powerful biomaterials for cancer immunotherapy.</P>
Duong Minh Cuong,Nguyen Hong Trang,Duong Bich Thuy 대한감염학회 2021 Infection and Chemotherapy Vol.53 No.4
Background: Coronavirus disease 2019 (COVID-19) vaccine acceptance is influenced by the trusted recommenders. This survey examined the public references, concerns, and trust in seven groups of recommenders regarding COVID-19 vaccine in Vietnam. Materials and Methods: A cross-sectional survey was conducted on 1,579 participants between April 16 and July 16, 2021. Participants’ references, concerns, and responses to vaccination recommendations made by government officials, employers, physicians, nurses, pharmacists, senior family members, and religious leaders were captured using a selfadministered questionnaire. Results: Rates of trust ranged from 18.5% to 89.1%. The highest rates were attributable to government (89.1%) and physicians (85.9%). Less than half of participants would accept the vaccines if pharmacists (45.5%), nurses (44.7%), employers (42.4%), senior family members (28.1%), and religious leaders (18.4%) recommended it. Only 37.6% of participants thought that vaccines were safe for them, while 57% were unsure. Most participants would wait and see how people respond to the vaccines before getting vaccinated (91.5%), preferred to receive the vaccines at public hospitals (88.6%), and were concerned about vaccine effectiveness (86.9%) and side effects (76.4%), while 61.8% were concerned about vaccine cost. Conclusion: Focusing on the personal benefit and relying on the government, physicians, and social role models would make the vaccine advertising campaigns more effective. If annual vaccinations were needed, providing the community with affordable vaccines would be an appropriate, long-term solution to ensure vaccination coverage in low-resource countries like Vietnam. Further studies are needed to examine reasons for the public reference of vaccination centers which may help in improving their confidence in getting the vaccine, regardless of the settings.
Duong, Huu Thuy Trang,Kim, Nak Won,Thambi, Thavasyappan,Giang Phan, V.H.,Lee, Min Sang,Yin, Yue,Jeong, Ji Hoon,Lee, Doo Sung Elsevier 2018 Journal of controlled release Vol.269 No.-
<P><B>Abstract</B></P> <P>Successful delivery of a DNA vaccine to antigen-presenting cells and their subsequent stimulation of CD4<SUP>+</SUP> and CD8<SUP>+</SUP> T cell immunity remains an inefficient process. In general, the delivery of prophylactic vaccines is mainly mired by low transfection efficacy, poor immunogenicity, and safety issues from the materials employed. Currently, several strategies have been exploited to improve immunogenicity, but an effective strategy for safe and pain-free delivery of DNA vaccines is complicated. Herein, we report the rapid delivery of polyplex-based DNA vaccines using microneedle arrays coated with a polyelectrolyte multilayer assembly of charge reversal pH-responsive copolymer and heparin. The charge reversal pH-responsive copolymer, composed of oligo(sulfamethazine)-<I>b</I>-poly(ethylene glycol)-<I>b</I>-poly(amino urethane) (OSM-<I>b</I>-PEG-<I>b</I>-PAEU), was used as a triggering layer in the polyelectrolyte multilayer assembly on microneedles. Charge reversal characteristics of this copolymer, that is, the OSM-<I>b</I>-PEG-<I>b</I>-PAEU copolymer exhibit, positive charge at low pH (pH4.03) and becoming negative charge when exposed to physiological pH conditions (pH7.4), allowing the facile assembly and disassembly of polyelectrolyte multilayers. The electrostatic repulsion between heparin and OSM-<I>b</I>-PEG-<I>b</I>-PAEU charge reversal copolymer triggered the release of DNA vaccines. DNA vaccines laden on microneedles are effectively transfected into RAW 264.7 macrophage cells <I>in vitro</I>. Vaccination of BALB/c mice by DNA vaccine-loaded microneedle arrays coated with a polyelectrolyte multilayer generated antigen-specific robust immune responses. These findings provide potential strategy of charge reversal pH-responsive copolymers coated microneedles for DNA vaccine delivery.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
The Levels of COVID-19 Related Health Literacy among University Students in Vietnam
Duong Minh Cuong,Nguyen Hong Trang,Duong Bich Thuy,Vu Minh Thuy 대한감염학회 2021 Infection and Chemotherapy Vol.53 No.1
Background: Vietnam is among the few countries that were successful in the fight against the first wave of coronavirus disease 2019 (COVID-19). However, subsequent domestic outbreaks of COVID-19 continue to occur. To sharp the community education program to guarantee the final success in the fight against COVID-19 in Vietnam and comparable countries, we examined the levels of COVID-19 knowledge and associated predictors among university students in Vietnam. Materials and Methods: A cross-sectional study was conducted on all students enrolling at Phenikaa University using a self-developed questionnaire consisted of 20 questions regarding COVID-19's risk factors, transmission routes, symptoms, and prevention. Results: Among 728 participants, 40.9% were male, 63.2% studied health-related majors, and 18.1% lived alone. Correct response rates ranged from 25.3% to 98.9% across 20 questions. Only 51.9% (378/728) of participants had good knowledge levels. Studying health majors (adjusted odds ratio [AOR] 0.547, 95% confidence interval [CI] 0.398 - 0.751, P <0.001), and living with the seniors (AOR 0.612, 95% CI 0.389 - 0.963, P = 0.034) or with friends (AOR 0.405, 95% CI 0.252 – 0.650, P <0.001) were negatively associated with a poor level of COVID-19 knowledge. Conclusion: The proportion of university students having good knowledge levels is suboptimal. It is essential to improve the quality of COVID-19 education with a more focus on not only the preventive measures, but also the disease itself. More studies are needed to improve the level of COVID-19 knowledge among those living alone or do not study healthrelated majors.