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김종훈,Toshio Hasegawa,Kurisu Tada,Yuki Uehara,Yukiko Fukui,Ayako Nakamura,Satomi Takei,Satoshi Mitarai,Akio Aono,Shigaku Ikeda 대한피부과학회 2023 Annals of Dermatology Vol.35 No.-
A 38-year-old female with systemic lupus erythematosus (SLE) initiated belimumab treat- ment. One month later, she presented with a reddish painful swelling on her right lower leg. She was treated with ceftriaxone and vancomycin. However, novel erythematous papules and indurated nodules appeared on both her lower legs. Skin biopsy revealed microabscess formation with mixed cell granuloma surrounded by inf lammatory cell infiltration within the dermis with subcutaneous fat tissue. A large number of acid-fast bacilli were observed with Ziehl–Neelsen staining. DNA sequencing of both the hsp65 and the 16S rRNA se- quences showed a 100% match with the corresponding region of Mycobacterium hae- mophilum . Mycobacterial culture revealed satellite growth enhancement on Middlebrook 7H11 agar plates around a paper strip containing hemin. She was treated with levof loxacin, rifabutin, and ethambutol. Within 13 months, her cutaneous lesions improved markedly without any side effects. The B cell-targeted biologic belimumab, a fully humanized IgG1γ monoclonal antibody that inactivates B lymphocyte stimulator, has been considered to be beneficial for active SLE. However, this therapy could increase the risk for the development of biologic therapy-associated mycobacterial infections, both tuberculosis and nontubercu- lous mycobacteria infections.
A New Approach for RTL Power Macro-Modeling
Hirofumi KAWAUCHI,Toshio MORIKAWA,Ryohei MURASHIMA,Ittetsu TANIGUCHI,Masahiro FUKUI 대한전자공학회 2009 ITC-CSCC :International Technical Conference on Ci Vol.2009 No.7
This paper presents a new power macro-modeling technique for resister transfer level (RTL). RTL power macro-modeling technique is well known as promising technique for fast power estimation. Our method is based on a table look-up constructed by statistical information extracted from the primary inputs to the circuit. In this paper, we propose a novel power estimation method with a new parameter SD. This parameter characterizes switching activity of an internal circuit. The switching activities of each gate are strongly related with the power consumption. Experimental results show that the proposed method improves RMS error about 10% in average with the ISCAS-85 combinational circuits. The average RMS error of our model was 4.5%.