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- 저자 : Tomoko Kaburagi (검색결과 1 건)
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Tomoko Kaburagi,Yuko Otsuka,Satoru Oshiro 한국식품영양과학회 2023 Journal of medicinal food Vol.26 No.8
The sialic acid N-acetylneuraminic acid (NANA), an essential factor in bioregulation, is a functional foodcomponent that is known to have beneficial health effects, but its antiobesity effect has not been clearly understood. Adipocytedysfunction in obesity involves a decrease in the level of NANA sialylation. In this study, we investigated the antiobesityeffect of NANA in mice fed a high-fat diet (HFD) and in 3T3-L1 adipocytes. Male C57BL/6J mice were randomly dividedinto three groups and administered the following diets: a normal diet, an HFD, and an HFD with 1% NANA supplementationfor 12 weeks. NANA supplementation significantly reduced body weight gain; epididymal adipose tissue hypertrophy; andserum lipid, fasting glucose, and aspartate transaminase levels compared with those in HFD mice. The percentage of lipiddroplets in hepatic tissue was also decreased by NANA supplementation in HFD mice. The downregulation of Adipoqexpression and upregulation of Fabp4 expression induced by HFD in epididymal adipocytes were improved by NANAsupplementation. The downregulation of Sod1 expression and increase in malondialdehyde level were induced by HFD, andthey were significantly improved in the liver by NANA supplementation, but not in epididymal adipocytes. However, NANAsupplementation had no effect on sialylation and antioxidant enzyme levels in mouse epididymal adipocytes and 3T3-L1adipocytes. Overall, NANA exerts antiobesity and antihypolipidemic effects and may be beneficial in suppressing obesityrelateddiseases.
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