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- 저자 : Tomoko KUSAMA (검색결과 6 건)
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Assessment of Salivary Human Herpesvirus-6 and Immunoglobulin A Levels in Nurses Working Shifts
Hiromi Fukuda,Takamichi Ichinose,Tomoko Kusama,Reico Sakurai 한국간호과학회 2008 Asian Nursing Research Vol.2 No.3
Purpose The purpose of the present study was to assess whether salivary human herpesvirus (HHV)-6 acted as a new sensitive stress marker, providing a reliable indicator of stress among shift work nurses. Salivary HHV-6, immunoglobulin (Ig) A and mood states were compared among nurses who worked day shifts only and nurses who worked different numbers of night shifts. Methods Participants included 56 female nurses working in Japanese general hospitals. The 56 subjects were categorized into three groups: Group A (n = 7), which consisted of nurses who only worked day shifts; group B (n = 29), which consisted of nurses working shifts with ≤8 night shifts per month; and group C (n = 20), which consisted of nurses working shifts with ≥ 9 night shifts per month. Mood was assessed using the Profile of Mood States Short Form Japanese version (POMS-SFJ). Salivary biomarker levels and mood were compared among the three groups. Results Although the salivary HHV-6 level was significantly higher in group C than in group A (p < .05), salivary IgA and mood levels were not significantly different among the three groups. Conclusion Salivary HHV-6 level may be a more sensitive stress marker than salivary IgA or mood for assessing chronic fatigue in nurses working shifts. Improvement to shift assignments using assessment by salivary HHV-6 is required. [Asian Nursing Research 2008;2(3):159–165] Purpose The purpose of the present study was to assess whether salivary human herpesvirus (HHV)-6 acted as a new sensitive stress marker, providing a reliable indicator of stress among shift work nurses. Salivary HHV-6, immunoglobulin (Ig) A and mood states were compared among nurses who worked day shifts only and nurses who worked different numbers of night shifts. Methods Participants included 56 female nurses working in Japanese general hospitals. The 56 subjects were categorized into three groups: Group A (n = 7), which consisted of nurses who only worked day shifts; group B (n = 29), which consisted of nurses working shifts with ≤8 night shifts per month; and group C (n = 20), which consisted of nurses working shifts with ≥ 9 night shifts per month. Mood was assessed using the Profile of Mood States Short Form Japanese version (POMS-SFJ). Salivary biomarker levels and mood were compared among the three groups. Results Although the salivary HHV-6 level was significantly higher in group C than in group A (p < .05), salivary IgA and mood levels were not significantly different among the three groups. Conclusion Salivary HHV-6 level may be a more sensitive stress marker than salivary IgA or mood for assessing chronic fatigue in nurses working shifts. Improvement to shift assignments using assessment by salivary HHV-6 is required. [Asian Nursing Research 2008;2(3):159–165]
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Effects of Stress on Mouse β-Defensin-3 Expression in the Upper Digestive Mucosa
Rie Kawashima,Keiichi Tsukinoki,Tomoko Shimizu,Masahiro To,Juri Saruta,Yoshinori Jinbu,Mikio Kusama 연세대학교의과대학 2014 Yonsei medical journal Vol.55 No.2
Purpose: Gastrointestinal integrity and immune surveillance are affected by stress. Stress also adversely affects mucosal barrier function. β-defensins constitute an integralcomponent of the innate immune system as antimicrobial peptides, serving as the first line of defense against microbial pathogens at the epithelial surfaces of the upper digestive mucosa. The primary objective of this study was to determine the effects of stress on the expression profile of mouse β-defensin-3 in the upper digestivemucosa of mice with diabetes. Materials and Methods: We established a mouse model of restraint stress by using NSY/Hos mice with type 2 diabetes mellitus. We used real-time polymerase chain reaction, in situ hybridization, and immunohistochemistryto investigate the effects of stress and glucocorticoid administrationon mouse β-defensin-3 expression in the upper digestive mucosa of the gingiva, esophagus, and stomach. Results: Mouse β-defensin-3 mRNA expression was higher in the esophagus than in the gingiva or stomach (p<0.05). In the esophagus, mouse β-defensin-3 mRNA expression was lower in stressed mice than in non-stressed mice (p<0.05). Furthermore, immunoreactivity to mouse β-defensin-3 proteinwas lower in the esophagus of stressed mice than non-stressed mice, consistent with the results of mRNA expression analysis. Systemic glucocorticoid administrationalso downregulated esophageal mouse β-defensin-3 mRNA expression. Conclusion:Our novel findings show that stress decreases mouse β-defensin-3 expressionin the esophagus of mice with diabetes, possibly due to increased endogenous glucocorticoid production. It appears to be highly likely that stress management may normalize mucosal antimicrobial defenses in patients with diabetes.
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GU,Yeunhwa,MORI,Takehiko,YAMAMOTO,Youichi,Hasegawa,Takeo,KUSAMA,Tomoko 대한방사선 방어학회 1999 방사선방어학회지 Vol.24 No.1
태생 8일째인 임신한 생쥐에 137-Cs 감마선과 초음파를 조사하였다. 복합조사의 경우 임신한 생쥐는 1.5 Gy 방사선과 1.0 W/㎠ 초음파로 -1, 0, 1, 3, 6 시간 간격으로 조사하였다. 사망과 외부 기형은 태생 18일에 검진하였다. 방사선에 의한 탠생 8일의 사망 임계값은 0.5에서 1.0 Gy 사이였으며, 초음파는 1.0에서 1.5 W/㎠ 사이였다. 태생 후반기의 사망은 방사선과 초음파의 복합 치료에 의해 상승적으로 증가되었다. 방사선에 의한 뇌탈출기형 및 무안구증의 임계값은 각각 0.5에서 1.0Gy사이와 1.0에서 1.5Gy 사이였다. 초음파에 의한 뇌탈출기형과 무안구증의 임계값은 각각 1.0에서 1.5W/㎠ 사이와 1.5 W/㎠ 이상이었다. 복합치료의 경우는 뇌탈출기형과 무안구증의 빈도가 상승적으로 증가하였다. 한 시간 간격으로 두 가지 치료를 받은 생쥐에서 뇌탈출기형과 무안구증의 빈도가 최고치에 도달하였다. Pregnant ICR mice were treated with 137Cs gamma-ray / ultrasound on day 8 of gestation. In combined treatments, pregnant mice were treated with both 1.5 Gy of radiation and 1.0 W/㎠ ultrasound at time intervals of -0, 1, 3 and 6 hours. The mortalities and external malformations were investigated on day 18 of gestation. The threshold dose of mortality induced by radiation on day 8 of gestation was between 0.5 and 1.0 Gy, and that which was induced by ultrasound was between 1.0 and 1.5 W/㎠. The mortalities in the late-stage of gestation induced by combined treatment with radiation and ultrasound increased synergistically. The threshold dose of exencephaly and anophthalmia induced by radiation were between 0.5 and 1.0 Gy and between 1.0 and 1.5 Gy, respectively. Those of exencephaly and anophthalmia induced by ultrasound were between 1.0 and 1.5 W/㎠ and more than 1.5 W/㎠, respectively. In combined treatments, the incidence of exencephaly and anophthalmia were found to increase synergistically. In the mice treated with both agents at a time interval of one hour, the incidence of exencephaly and anophthalmia reached maximum levels.
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