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RISS 인기검색어
- 검색키워드
- 저자 : Tom L. Broderick (검색결과 2 건)
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Feeding Obese Diabetic Mice a Genistein Diet Induces Thermogenic and Metabolic Change
Schuyler Rockwood,Tom L. Broderick,Layla Al-Nakkash 한국식품영양과학회 2018 Journal of medicinal food Vol.21 No.4
Obesity is associated with elevated plasma levels of glucocorticoids and reduced levels of thyroid hormones, both known to effect food intake and energy expenditure. Furthermore, tissue specific glucocorticoid metabolism is altered in obesity, increasing insulin resistance and cardiometabolic risk. The goal of this study was to examine whether these metabolic disturbances can be prevented with the isoflavone genistein in the ob/ob mouse, a model that resembles the phenotype in human obesity. Male ob/ob mice, aged 5 weeks, were fed either a genistein-rich diet (600 mg/kg) or a genistein-free diet for 4 weeks. ob/ob mice weighed 70% more than lean controls. While there was no effect of genistein on body weight, food consumption during weeks 3 and 4 was significantly increased in genistein-fed mice. This was associated with increases in body temperature and plasma levels of triiodothyronine (T3), suggesting a thermogenic effect. The hypercorticosteronism observed in the ob/ob mouse was reduced with genistein treatment. This effect was accompanied by a decrease in protein expression of renal 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) without changes in hepatic 11β-HSD1. Our results suggest that a diet containing genistein can have beneficial effects on energy expenditure, T3 production, and corticosterone status in the ob/ob mouse model of obesity.
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Layla Al-Nakkash,Brandon Markus,Lyn Batia,Walter C. Prozialeck,Tom L. Broderick 한국식품영양과학회 2010 Journal of medicinal food Vol.13 No.6
This study aimed to determine whether a 2-week genistein treatment induced estrogen-like effects in ovariectomized (OVX) Sprague-Dawley rats, after 2 weeks of subcutaneous genistein injections (250mg/kg of body weight/day). Uterine weight, uterine-to-body weight ratio, femur weight, and femur-to-body weight ratio were all significantly increased with genistein in OVX rats. Body weight was significantly decreased with genistein in OVX rats. Genistein had no effect on the weights of heart, heart-to-body ratio, and fat pad but significantly decreased heart rate and pulse pressure. Genistein had no effect on cardiac GLUT4 protein, oxidative stress, plasma glucose, nonesterified fatty acids, or low-density lipoprotein levels; however, plasma insulin levels were significantly increased. Our results show that a 2-week genistein treatment produced favorable estrogen-like effects on some physical and physiological characteristics in OVX rats. However, based on our experimental conditions, the effects of genistein were not associated with changes in cardiac GLUT4 or oxidative stress.
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