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- 저자 : Tom J Webster (검색결과 3 건)
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K. Walters,H.R. Tamaddon-Jahromi,M.F. Webster,M.F. Tomé,S. McKee 한국유변학회 2009 Korea-Australia rheology journal Vol.21 No.4
In various attempts to relate the behaviour of highly-elastic liquids in complex flows to their rheometrical behaviour, obvious candidates for study have been the variation of shear viscosity with shear rate, the two normal stress differences N1 and N2, especially N1, and the extensional viscosity ηE. In this paper, we shall be mainly interested in ‘constant-viscosity’ Boger fluids, and, accordingly, we shall limit attention to N1 and ηE. We shall concentrate on two important flows - axisymmetric contraction flow and “splashing” (particularly that which arises when a liquid drop falls onto the free surface of the same liquid). Modern numerical techniques are employed to provide the theoretical predictions. It is shown that the two obvious manifestations of viscoelastic rheometrical behaviour can sometimes be opposing influences in determining flow characteristics. Specifically, in an axisymmetric contraction flow, high ηE can retard the flow, whereas high N1 can have the opposite effect. In the splashing experiment, high ηE can certainly reduce the height of the so-called Worthington jet, thus confirming some early suggestions, but, again, other rheometrical influences can also have a role to play and the overall picture may not be as clear as it was once envisaged.
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Biocompatability of carbon nanotubes with stem cells to treat CNS injuries
Kiran Kumar Bokara,Jong Youl Kim,Young Il Lee,Kyungeun Yun,Tom J Webster,Jong Eun Lee 대한해부학회 2013 Anatomy & Cell Biology Vol.46 No.2
Cases reporting traumatic injuries to the brain and spinal cord are extended range of disorders that affect a large percentage of the world's population. But, there are only few effective treatments available for central nervous system (CNS) injuries because the CNS is refractory to axonal regeneration and relatively inaccessible to many pharmacological treatments. The use of stem cell therapy in regenerative medicine has been extensively examined to replace lost cells during CNS injuries. But, given the complexity of CNS injuries oxidative stress, toxic byproducts, which prevails in the microenvironment during the diseased condition, may limit the survival of the transplanted stem cells affecting tissue regeneration and even longevity. Carbon nanotubes (CNT) are a new class of nanomaterials, which have been shown to be promising in different areas of nanomedicine for the prevention, diagnosis and therapy of certain diseases, including CNS diseases. In particular, the use of CNTs as substrates/scaffolds for supporting the stem cell differentiation has been an area of active research. Single-walled and multi-walled CNT's have been increasingly used as scaffolds for neuronal growth and more recently for neural stem cell growth and differentiation. This review summarizes recent research on the application of CNT-based materials to direct the differentiation of progenitor and stem cells toward specific neurons and to enhance axon regeneration and synaptogenesis for the effective treatment of CNS injuries. Nonetheless, accumulating data support the use of CNTs as a biocompatible and permissive substrate/scaffold for neural cells and such application holds great potential in neurological research.
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