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RISS 인기검색어
- 검색키워드
- 저자 : Ticconi, Carlo (검색결과 2 건)
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Uterine blood flow indices, antinuclear autoantibodies and unexplained recurrent miscarriage
( A. Pietropolli ),( Valentina Bruno ),( M. V. Capogna ),( S. Bernardini ),( E. Piccione ),( C. Ticconi1 ) 대한산부인과학회 2015 Obstetrics & Gynecology Science Vol.58 No.6
Objective To study the correlation between 2D and 3D uterine flow indexes and the presence or the absence of antinuclear antibodies (ANA) in women with unexplained recurrent miscarriage (uRM). Methods Fifty-two subjects (26 uRM and 26 control women) underwent 2D Doppler measurement of pulsatility index and resistance index of the uterine arteries in both the follicular and midluteal phase of the cycle. Additionally, 3D ultrasonography determination of vascularisation index, flow index, and vascularisation flow index was carried out with the aid of the VOCAL technique. Serum assay for the presence of ANA was performed in all women. Results Pulsatility index of ANA+ uRM women was higher than that of ANA- uRM women and control ANA+ and ANAwomen, both in the follicular and in the midluteal phase of the cycle. Vascularisation index in ANA- uRM women was significantly higher than that in ANA+ control women. Flow index in uRM ANA+ women was significantly lower than that of each of the other groups. Conclusion ANA might be involved in uRM by determining an impairment in uterine blood flow hemodynamic, particularly in uterine blood flow intensity and uterine artery impedance.
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RBPJ mediates uterine repair in the mouse and is reduced in women with recurrent pregnancy loss
Strug, Michael R.,Su, Ren‐,Wei,Kim, Tae Hoon,Mauriello, Alessandro,Ticconi, Carlo,Lessey, Bruce A.,Young, Steven L.,Lim, Jeong Mook,Jeong, Jae‐,Wook,Fazleabas, Asgerally T. Federation of American Society for Experimental Bi 2018 The FASEB Journal Vol.32 No.5
<P>Unexplained recurrent pregnancy loss (uRPL) is associated with repeated embryo loss and endometrial repair with elevated endometrial expression of inflammatory cytokines, including IFN-gamma. Notch signaling through its transcription factor recombination signal binding protein J kappa (RBPJ) regulates mechanisms including the immune response and repair after tissue injury. Initially, null mutation of RBPJ in the mouse uterus (Pgr(cre/+)Rbpj(f/f); Rbpj c-KO) results in subfertility, but we have found that these mice become infertile after pregnancy as a result of dysfunctional postpartum uterine repair, including delayed endometrial epithelial and myometrial regeneration. RNA sequencing of postpartum uterine repair sites revealed global up-regulation of inflammatory pathways, including IFN signaling. Consistent with elevated IFN-gamma, macrophages were recruited and polarized toward an M1-cytotoxic phenotype, which is associated with preventing repair and promoting further tissue injury. Through embryo transfer experiments, we show that dysfunctional postpartum repair directly impairs future embryo implantation in Rbpj c-KO mice. Last, we clinically correlated our findings from the Rbpj c-KO mouse in women diagnosed with uRPL. Reduced RBPJ in women with uRPL was associated with increased levels of IFN-gamma. The data, taken together, indicate that RBPJ regulates inflammation during endometrial repair, which is essential for future pregnancy potential, and its dysregulation may serve as an unidentified contributor to uRPL in women.</P>
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