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Ikuo Konishi,Kaoru Abiko,Takuma Hayashi,Koji Yamanoi,Ryusuke Murakami,Ken Yamaguchi,Junzo Hamanishi,Tsukasa Baba,Noriomi Matsumura,Masaki Mandai,Kyoto Study Group for Ovarian Cancer Research 대한부인종양학회 2022 Journal of Gynecologic Oncology Vol.33 No.5
Epithelial ovarian cancer remains the lethal gynecological malignancy in women. The representative histotype is high-grade serous carcinoma (HGSC), and most patients with HGSC present at advanced stages with peritoneal dissemination. Since the peritoneal dissemination is the most important factor for poor prognosis of the patients, complete exploration for its molecular mechanisms is mandatory. In this narrative review, being based on the clinical, pathologic, and genomic findings of HGSC, chromosomal instability and epigenetic dynamics have been discussed as the potential drivers for cancer development in the fallopian tube, acquisition of cancer stem cell (CSC)-like properties, and peritoneal metastasis of HGSC. The natural history of carcinogenesis with clonal evolution, and adaptation to microenvironment of peritoneal dissemination of HGSC should be targeted in the novel development of strategies for prevention, early detection, and precision treatment for patients with HGSC.
Tomoaki Okuda,Weidong Jing,Katsutomo Saito,Takuma Okamoto,Hibiki Saito,Kazuki Sugimoto,Chiharu Nishita-Hara,Keiichiro Hara,Masahiko Hayashi,Shuichi Hasegawa 한국대기환경학회 2022 Asian Journal of Atmospheric Environment (AJAE) Vol.16 No.2
The valence state and concentration of metallic pollutants are important factors contributing to the health effects of respirable particulate matter (PM); however, they have not been well studied. In this study, coarse and fine powder samples of atmospheric PM were collected using a cyclone system at Kanagawa (KO), Saitama (SA), and Fukuoka (FU) in Japan in 2017. Energy dispersive X-ray fluorescence spectroscopy (EDXRF) was used to measure the concentrations of nine metallic elements (Ti, V, Cr, Mn, Fe, Ni, Cu, Zn, and Pb), and X-ray absorption fine structure (XAFS) spectroscopy was used to analyze the valence states of target elements (Cr, Mn, Fe, Cu, and Zn). The EDXRF results indicated that the average contents of Fe, Ti, and Zn were much higher than those of the other six elements in all samples. The XAFS results showed that the major valence states of the elements were Cr(III), Mn(II), Fe(III), Cu(II), and Zn(II). The percentages of Mn(IV), Fe(II), and Cu(0) were higher in KO and SA samples than in FU samples. Mn(0) and Zn(0) were detected in some samples only, and Cu(I) was not detected in any samples. Correlation analysis, principal component analysis, and cluster analysis were performed on the EDXRF and XAFS data of the target elements. The source identification results showed that the sources of metal contaminants in the samples varied considerably between sampling sites and depended on the industrial structure and geographical location of the sampling area. Our findings on the different valence states of the elements may be important for determining the toxicity of PM at different locations.
( Masaki Kuwatani ),( Toru Nakamura ),( Tsuyoshi Hayashi ),( Yasutoshi Kimura ),( Michihiro Ono ),( Masayo Motoya ),( Koji Imai ),( Keisuke Yamakita ),( Takuma Goto ),( Kuniyuki Takahashi ),( Hiroyuki 대한소화기기능성질환·운동학회(구 대한소화관운동학회) 2020 Gut and Liver Vol.14 No.2
Neoadjuvant chemotherapy/neoadjuvant chemoradiotherapy (NAC/NACRT) can be performed in patients with pancreatic cancer to improve survival. We aimed to clarify the clinical outcomes of biliary drainage with a metal stent (MS) or a plastic stent (PS) during NAC/NACRT. Between October 2013 and April 2016, 96 patients with pancreatic cancer were registered for NAC/NACRT. Of these, 29 patients who underwent biliary drainage with MS or PS before NAC/NACRT and a subsequent pancreatoduodenectomy were retrospectively analyzed with regard to patient characteristics, preoperative recurrent biliary obstruction rate, NAC/NACRT delay or discontinuation rate, and operative characteristics. The median age of the patients was 67 years. NAC and NACRT were performed in 14 and 15 patients, respectively, and MS and PS were used in 17 and 12 patients, respectively. Recurrent biliary obstruction occurred in 6% and 83% of the patients in the MS and PS groups, respectively (p<0.001). NAC/NACRT delay was observed in 35% and 50% of the patients in the MS and PS groups, respectively (p=0.680). NAC/NACRT discontinuation was observed in 12% and 17% of the patients in the MS and PS groups, respectively (p=1.000). The operative time in the MS group tended to be longer than that in the PS group (625 minutes vs 497 minutes, p=0.051), and the operative blood loss volumes and postoperative adverse event rates were not different between the two groups. MS was better than PS from the viewpoint of preventing recurrent biliary obstruction, although MS was similar to PS with regards to perioperative outcomes. (Gut Liver 2020;14:269-273)