The Efficacy of Pharmacological Treatment in Pediatric Nonalcoholic Fatty Liver Disease

Taeshik Cho,김용주,백승삼 대한소아소화기영양학회 2012 Pediatric gastroenterology, hepatology & nutrition Vol.15 No.4

Purpose: With growing number of obese children, the prevalence of nonalcoholic fatty liver disease (NAFLD) in pediatric population is increasing. Nonalcoholic steatohepatitis (NASH) is a severe form of NAFLD, and can cause morbid complications. It is important to identify patients in order to grade pathologic severities and treat those children who possibly have NASH. This study was performed to evaluate whether the pharmacological therapy is also effective as well as the body weight reduction in pediatric NAFLD. Methods: Among the 52 children presenting with obesity and hepatopathy, NAFLD was diagnosed through liver biopsy in 29 children, who were 7 to 14 years of age, from January 2006 to December 2011. The patients were advised to reduce their body weight through diverse methods. Medication with Ursodeoxycholic acid (UDCA) and vitamin E was performed in children whose liver functions did not improve or their weight reductions were not successful. The therapeutic effects were monitored and assessed via the biochemical profiles and the physical measurements. Results: The therapy of vitamin E and UDCA combined with body mass index (BMI) reduction showed significantly higher rate of improvement in clinical profiles, which could be seen in data of aspartate aminotransferase (AST), alanine aminotransferase (ALT), AST/ALT ratio, alkaline phosphatase, total bilirubin and γ-glutamyl transpeptidase. Children whose BMI were successfully reduced showed favorable clinical improvements without any medication, but those without BMI reduction did not show any improvement despite medications. Conclusion: This study showed that the first line of therapy should be the BMI reduction in NAFLD and drug therapy combined with BMI reduction could have additive therapeutic effect in children with NAFLD.

Healing Graphene Defects Using Selective Electrochemical Deposition: Toward Flexible and Stretchable Devices

Yoon, Taeshik,Kim, Jae-Han,Choi, Jun Hyung,Jung, Dae Yool,Park, Ick-Joon,Choi, Sung-Yool,Cho, Nam Sung,Lee, Jeong-Ik,Kwon, Young-Duck,Cho, Seungmin,Kim, Taek-Soo American Chemical Society 2016 ACS NANO Vol.10 No.1

<P>Graphene produced by chemical-vapor-deposition inevitably has defects such as grain boundaries, pinholes, wrinkles, and cracks, which are the most significant obstacles for the realization of superior properties of pristine graphene. Despite efforts to reduce these defects during synthesis, significant damages are further induced during integration and operation of flexible and stretchable applications. Therefore, defect healing is required in order to recover the ideal properties of graphene. Here, the electrical and mechanical properties of graphene are healed on the basis of selective electrochemical deposition on graphene defects. By exploiting the high current density on the defects during the electrodeposition, metal ions such as silver and gold can be selectively reduced. The process is universally applicable to conductive and insulating substrates because graphene can serve as a conducting channel of electrons. The physically filled metal on the defects improves the electrical conductivity and mechanical stretchability by means of reducing contact resistance and crack density. The healing of graphene defects is enabled by the solution-based room temperature electrodeposition process, which 'broadens the use of graphene as an engineering material.</P>

Association between long working hours and health related quality of life

Taeshik Kim(김대식),Mo-Yeol Kang(강모열),Min-sang Yoo(유민상),Soo-Hun Cho(조수헌),Yun-Chul Hong(홍윤철) 환경독성보건학회 2013 한국독성학회 심포지움 및 학술발표회 Vol.2013 No.10

도시의 방재안전관리를 위한 도시페기물의 전략적 접근방법에 관한 연구

이태식(TaeShik Lee),조원철(WonCheol Cho) 한국방재안전학회 2014 한국방재안전학회 논문집 Vol.7 No.1

This research has been shown the strategic disaster prevention and safety management’s methodology that minimize the demage and loss from environmental disaster: it is made the renewable energy using the urban wastes causing the main environmental disaster, it minimize the generating cost from the environmental disaster, it gain the energy source for preparing the large-scale shutdown electricity, it gain the profit from the continuous electric power and heat energy’s generating, it gain the renewal energy source from the old urban wastes’ landfill, it give back the citizen the clean environment, the construction cost is able to be solved form the profit which the power plant is made the plasma gasification generation of the urban wastes, it create the new related jobs in the local government, it base to be invested the local industrial zone’s commercialization due to the renewal energy power plant. Especially, in happen to the large-scale natural disaster’s typhoon and earthquake, in the result generating the large-scale urban wastes, it is shown the prepared and robust model which contribute the preventing recovery of the local economy using the renewal energy of the urban wastes, and the strategic disaster prevention and safety management’s method in the future city. 본 연구는 환경재난의 주요 원인인 도시 폐기물을 신속하게 신재생에너지로 재활용하여 환경오염과 악취 등의 피해 규모를 최소화하면서, 도시는 환경재난 발생비용을 최소화하고, 신재생에너지를 대정전에 대비한 에너지원으로 확보하고, 지속적인 전기에너지와 열에너지 수익원을 확보하면서, 기존에 매장된 도시 폐기물을 발굴하여 재활용하여 환경오염지역을 청정지역으로 재생산하여 깨끗한 환경을 시민에게 돌려주고, 발생되는 수익원으로부터 방재안전관리형 플라즈마 가스화 발 전소 건설비용을 해결할 수 있고, 지방자치단체에 새로운 일자리를 창출할 수 있고, 신재생에너지원을 확보함으로 인하여, 지역의 혁신경제성장단지를 유치할 수 있는 인프라를 구축하는데 기여하는 등의 전략적 방재안전관리 접근방법을 제시하였다. 특히, 기후변화에 의한 대규모 자연재해인 태풍과 지진 등이 발생할 경우, 도시 폐기물이 다량으로 발생하게 되므로, 이를 신재생에너지화 하여 지역경제의 예방복구에 기여할 수 있는 원동력이 될 수 있도록 기후변화에 강건한 조건을 갖춘 모델 을 제시하여, 미래도시의 전략적 방재안전관리 방안을 제시하였다.

재난환경변화에 대응한 인적재난 R&D중장기 로드맵 수립 기획연구

이태식(TaeShik Lee),석금철(GeumCheol Seok),안재우(JaeWoo An),송철호(CheolHo Song),정종수(ChongSoo Cheung),이영재(YoungJae Lee),조원철(WonCheol Cho) 한국방재안전학회 2014 한국방재안전학회 논문집 Vol.7 No.1

본 연구는 재난환경 변화에 대응한 인적재난 R&D 중장기 로드맵 수립 기획에 관한 것으로서, 인적재난 안전기술 분야의 기술개발 투자 확대 방안 및 관련분야 선진국 대비 기술수준 격차해소를 위한 전략 제시, 인적재난안전기술개발 사업의 차세대대응기술 예측을 통한 사업 고도화, 중장기 로드맵 및 중점추진전략 도출, 중점 추진전략에 따른 주요 추진사업 및 세부추진과제 RFP 도출 등의 방안을 제시하였다. 주요 성과로서, 인적재난안전기술개발 중장기 투자 확대, 미래 인적재난 발생 가능성 예측을 통한 향후 재난대응 환경 변화와 안전관리 정책관련 패러다임 예측 및 효율적 대응, 인적재난안전기술 개발 중장기 로드맵을 통해 인적재난기술의 가치향상과 미래도약 기반강화 등이 기대된다. This research has been shown the Research Plan for R&D Long-term Load-map Design in the Facility Disaster on response of the changing Disaster Environment, Showing the Strategy for the extending investment method of the technical development and related on that the advanced nation’s technical level gap is minimized in the same area, Designing for the business’ high-level, long-term load-map and the core driving strategy of the safety technology development business in the facility disaster, RFP Documentation on the core driving Business and the detailed driving Issue. This research has been resulted the three lists, trend analysis and Vision of the Technology Research Development (R&D) of the Safety Technology Area in domestic and foreign, the Responding Technology Predict and the Extended Research Strategy of the Next Generation Safety Technology in the facility Disaster, long-mid Term Road-Map of the Safety Technology in the facility Disaster, finally the Action Issue’s RFP of the Safety Technology in the facility Disaster.

인간보호를 위한 안전모니터링 이론과 적용에 관한 연구

이태식(TaeShik Lee),서정표(JungPyo Seo),석금철(GeumCheol Seok),조원철(WonCheol Cho) 한국방재안전학회 2012 한국방재안전학회 논문집 Vol.5 No.1

This paper focused on the new theory and algorithm improving the citizen’s safety which they experience to change from the developing country to the developed country, and analyzed the gained and applicate results, and show the theories and application’s evidence for the incident prevention of citizen’s life and house. The Safety Monitoring Theory for human security, show the six theories for which they are analyzed and reduced the accident’s death, as is the priority of the disaster prevention activity, its decision, continuous minimization of the accident’s death number, the environment security, the personal security, the community security. This study is applied to educate and exercise the disaster prevention and safety management’s program which applied the seven step’s model of the safety monitoring, show on continuously improvement effects through the case study of the personal’s and team’s monitoring during five years. 본 연구에서는 개발도상국에서 선진국으로 발전하는 과정에서 겪는 시민안전 향상을 위한 새로운 이론과 알고리즘 을 제시하고 있으며, 얻어지고 적용된 결론을 분석하고, 시민의 생명과 재산을 재난으로부터 보호하기 위한 이론과 적용된 사례를 보여주고 있다. 인간보호를 위한 안전모니터링 이론은 사고로 인한 사망자를 분석하여 감소시킬 수 있는 여섯가지 이론을 제시하고 있으며, 이는 재해예방활동의 우선순위, 의사결정, 사건사망자수의 지속적인 최소화, 환경안보, 개인안보, 공동체 안보 등이다. 이 연구는 일곱 단계로 구성된 안전모니터링 모델을 적용한 방재안전관리 프로그램을 교육하고 훈련하는데 적용되었고, 5년간의 개인활동과 그룹활동 사례연구를 통한 지속적으로 향상된 효과를 제시하였다.

Solid cross linked-poly(ethylene oxide) electrolyte gate dielectrics for organic thin-film transistors

Sungmin Cho,Dongkyu Kim,Yeongkyu Yun,Jeongyeon Lee,Taeshik Earmme,SungYong Seo,Choongik Kim 한국공업화학회 2020 Journal of Industrial and Engineering Chemistry Vol.92 No.-

Solid polymer electrolyte gate dielectric based on cross-linked poly(ethylene oxide) (CPEO) was developed and employed for organic thin-film transistors (OTFTs). Mechanical stability, high areal capacitance, and amorphous morphology of CPEO were achieved via the use of polyhedral oligomeric silsesquioxane (POSS) as cross-linker, dissolved ion [EMIM][TFSI] as electrolyte, and PEO with low molecular weight as polymer matrix, respectively. The resulting solid polymer electrolyte showed excellent insulating properties with low leakage current density (1.8 × 10−7 A cm−2 at 1 V) and high capacitance per area (∼ 1 μF cm−2 at 100 Hz). Furthermore, dielectric properties of the developed polymer electrolytes including ionic conductivity as well as segmental relaxation time were investigated. The polyelectrolyte dielectric was employed for bottom-gate/top-contact organic thin-film transistors and the resulting devices showed decent electrical performance with a carrier mobility of 0.12 (±0.03) cm2 V−1 s−1 and a current on/off ratio of 103 at low operating voltage of 5 V.

Direct Measurement ofAdhesion Energy of MonolayerGraphene As-Grown on Copper and Its Application to Renewable TransferProcess

Yoon, Taeshik,Shin, Woo Cheol,Kim, Taek Yong,Mun, JeongHun,Kim, Taek-Soo,Cho, Byung Jin American ChemicalSociety 2012 Nano letters Vol.12 No.3

<P>Direct measurement of the adhesion energy of monolayer graphene as-grown on metal substrates is important to better understand its bonding mechanism and control the mechanical release of the graphene from the substrates, but it has not been reported yet. We report the adhesion energy of large-area monolayer graphene synthesized on copper measured by double cantilever beam fracture mechanics testing. The adhesion energy of 0.72 +/- 0.07 J m(-2) was found. Knowing the directly measured value, we further demonstrate the etching-free renewable transfer process of monolayer graphene that utilizes the repetition of the mechanical delamination followed by the regrowth of monolayer graphene on a copper substrate.</P>

방재안전 자연광 LED 조명을 이용한 생활안전 개선에 관한 연구

이태식(Taeshik Lee),석금철(Gumcheul Seok),소유섭(Yooseb So),최병식(Byungshik Choi),김재권(Jaekwon Kim),조원철(Woncheol Cho) 한국방재안전학회 2016 한국방재안전학회 논문집 Vol.9 No.2

본 연구는 방재안전 자연광 LED 조명을 이용하여 환경을 개선하여, 생활안전 분야에서 자살, 감염병, 안전사고, 교 통사고, 범죄, 화재, 자연재해 등에서 발생하는 사망자를 줄이고, 칼라조명의 유연성을 활용하여, 건강과 환경과 안전을 향 상시킬 수 있는 새로운 LED 조명사용법을 제시하고자 한다. 연구조사된 내용으로는, 2016년 11월 3주간, 서울 북부지역에 거주하는 우울증 증세의 주민 10명(평균 거주기간 28.7년, 연령 67.5세)을 대상으로, 본인의 요청에 의하여 가정침실 혹은 거실에 방재안전 자연광 LED 조명을 설치하여 사용 후 조사한 바, 신체적, 정신적 안정감을 회복하는 기능에 대한 기대감 은 88%로 높게 나타났고, 이와 동일하게 1주와 3주 후의 신체적, 정신적 변화에 대한 비교조사를 하여 본 결과, 1주차에는 84%에서 3주차 이후에는 90%로 우울증 해소효과가 높은 효과가 있음을 알 수 있었다. 우울증 환자의견을 종합하면, 잠도 잘자고 불안한 마음이 없어졌고, 안정감이 생기고, 숙면을 취할 때가 많아 졌으며, 너무 좋다 등의 효과를 보였다고 하였다. 방재안전 환경조명은, 자살자를 감소시키고, 감염병으로부터 면역력을 증가시켜 주며, 부주의로 인한 추락 안전사고를 예방 하여 주며, 교통사고 발생빈도가 높은 지점에 설치하여 대형차량의 안전운전을 향상시키고, 지역사회의 안전을 위한 안전귀 가길의 안전기능을 향상시키고, 화재로 인한 소방관의 정신적 불안 증세를 완화시켜 주며, 자연재해로 인한 장기간 상황실 근무시 의사결정력을 향상시키기 위한 환경조성 등에 크게 개선하여, 시민을 덜 죽고, 덜 다치고, 안전한 지역사회 건설에 기여할 것으로 기대된다. This paper is shown the new method using LED Light, which the light environment is upgraded the natural LED light in the area of Disaster Prevention and Safety Management (PDSD), which the events of deaths is reduced on the Suicide, the Infectious diseases, the safety accidents, the Traffic Accident, the crime, the fire, the Nature Disaster, and which the health and the environment and the safety is implemented using the value of the color LED Light. Research findings include, during 3 weeks in the November 2016, in the ten residents (average living 28.7 years, age 67.5 years) with depressive symptoms in the northern part of Seoul, according to the request of the user, the PDSD natural light LED lighting was installed in the home bedroom or the living room, expectations for the ability to restore physical and mental stability were high (88%), in the same way, after 1 week and 3 weeks, the physical and mental changes were compared and the results, 84% in the first week and 90% in the third week and thereafter, the effect of relieving depression was high. We conclude that patients with depression have a good sleep, an uneasy feeling, a sense of security, a good night s sleep, and a good feeling. The PDSD LED Light is expected to contribute in the various areas, which reduced the suicides, which give increased immunity from infectious diseases, which give a crash to reduce accidents caused by negligence, which improve the safe operation of heavy vehicles in which a traffics accident incidence installed on the highest point, which improve the safety function on the ‘safety way home’ for the safety of the community, which due to fire gives alleviate the emo-tional anxiety of firefighters, which improve the environment for long-term control room working during decision making caused by natural disasters.

시민보호를 위한 생활안전 마을지도 설계에 관한 연구

이태식(TaeShik Lee),석금철(GeumCheol Seok),조원철(WonCheol Cho) 한국방재안전학회 2013 한국방재안전학회 논문집 Vol.6 No.3

This paper focused on the continuing the citizen safety, the contributing the local economy’s activation, and the improving the safe and the social walfare on the civil environment. Seoul metropolitan nominated the model village the Buggaja 2 dong of the Seodaemoon-gu for the making safe village in the 2013. It is designed the village map for the safe life, discovered the dangerous factor about the various and social facilities which is a road, a walking way, a school, a enjoy place for the children, a Thema place, the leasure place, facilities etc., and improved the model village for the incident’s and accident’s reduction education and training from 2011 to 2013. The results on the discovering and improving activities by the resilient safe monitoring activity, in the 2011 the village is reduced the 23 people from the 151 people to the 128 people in the dead number into the total citizen 34,000 during a year, is showed the excellent values, which the dead people reduced the 23 people in the village, which the safe-life result was over the 12.8% in the national average. For the making resilient city, for the supporting the visitors which it looks around the safe-life model village, the tracking road map is designed, and the tenth safe life factors is showed. 본 연구에서는 시민의 안전을 확보하고, 이를 통한 지역경제 활성화에 기여하며, 시민의 복지환경인 안전복지와 사회복지 환경을 개선 등을 이루기 위하여 마을의 안전을 확보하기 위한 시범마을로 서울시 서대문구 북가좌2동을 선정하고, 이 마을에서 2011년부터 사건사고와 재해재난 등이 발생할 수 있는 요인인 차도, 인도, 학교내, 놀이터, 공연장, 휴식장소, 건축물 등 다양한 사회적 변화 시설물에 대한 위험요인을 발굴하고 이를 개선한 내용을 재해경감 교육과 훈련 목적으로 한 곳에 정리하여 생활안전 마을지도를 설계하였다. 3년간 지속적으로 안전모니터링에 의하여 위험요소 발굴 및 개선활동을 한 결과, 2011년부터 마을의 사망자가 2010년 시민 34,000여 명 중 151명 사망자에서 128명으로 23명이 감소하였으며, 이는 한국의 평균 사건사고 사망자 비율인 12.8%인 인구대비 18명으로부터 5명이 더 추가로 감소되었다. 재해에 강한 도시를 만들고, 안전모델 마을을 방문하기 원하는 사람들을 돕기 위하여 탐방로지도와 10대 생활안전 요인들을 제시하였다.