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Porthin Markus,신성민,Quatrain Richard,Tyrväinen Tero,Sedlak Jiri,Brinkman Hans,Müller Christian,Picca Paolo,Jaros Milan,Natarajan Venkat,Piljugin Ewgenij,Demgné Jeanne 한국원자력학회 2023 Nuclear Engineering and Technology Vol.55 No.12
Nuclear power plants are increasingly being equipped with digital I&C systems. Although some probabilistic safety assessment (PSA) models for the digital I&C of nuclear power plants have been constructed, there is currently no specific internationally agreed guidance for their modeling. This paper presents an initiative by the OECD Nuclear Energy Agency called “Digital I&C PSA – Comparative application of DIGital I&C Modelling Approaches for PSA (DIGMAP)”, which aimed to advance the field towards practical and defendable modeling principles. The task, carried out in 2017–2021, used a simplified description of a plant focusing on the digital I&C systems important to safety, for which the participating organizations independently developed their own PSA models. Through comparison of the PSA models, sensitivity analyses as well as observations throughout the whole activity, both qualitative and quantitative lessons were learned. These include insights on failure behavior of digital I&C systems, experience from models with different levels of abstraction, benefits from benchmarking as well as major contributors to the core damage frequency and those with minor effect. The study also highlighted the challenges with modeling of large common cause component groups and the difficulties associated with estimation of key software and common cause failure parameters
Shin, Mingue,Kim, Joonyun,Jung, Young-Kwang,Ruoko, Tero-petri,Priimagi, Arri,Walsh, Aron,Shin, Byungha The Royal Society of Chemistry 2019 Journal of materials chemistry. C, Materials for o Vol.7 No.13
<P>We report the formation of a new class of solvent-intercalated two-dimensional (SI-2D) formamidinium lead halide perovskites. They can be mixed with three-dimensional (3D) stoichiometric perovskites by controlling the ratio of the precursor solutions. The composite leads to greatly improved photoluminescence quantum yield (PLQY) over the 3D compound. The enhanced PLQY is attributed to a type-I band alignment between the 3D and SI-2D, as revealed by first-principles calculations, which results in confined excitons with enhanced radiative recombination. The films exhibited excellent thermal and air stability retaining PLQY > 20% over 2 months in ambient conditions. Assemblies of halide perovskites with mixed dimensionality offer a pathway to enhance optoelectronic performance and device lifetimes.</P>
Kati Kristiina Kyrölä,Järvenpää Salme,Järviluoma Tuija,Irmola Tero,Kauppinen Eero,Häkkinen Arja 대한척추신경외과학회 2018 Neurospine Vol.15 No.2
Objective: To evaluate the intra- and interrater reliability (I-IR) of sagittal spinopelvic parameters from digital full-spine plain radiographs with basic software tools in an unselected adult population with degenerative spinal complaints who were evaluated for surgery. Methods: Forty-nine adult full-spine digital radiographs were measured twice by 3 independent observers, including an experienced spine surgeon, an experienced radiologist, and a resident orthopedic surgeon. Clinical picture archiving and communication system workstations and software tools were used and landmarks were set manually. The I-IR of the sagittal vertical axis (SVA), pelvic tilt (PT), pelvic incidence (PI), sacral slope (SS), and thoracic kyphosis in T4–T12 (TK) were assessed. Results: The intrarater intraclass correlation coefficient (ICC) scores varied from 0.82 to 0.99. The interrater ICC scores ranged from 0.78 to 0.99. The intrarater standard error of measurement (SEM) values for SS, PT, PI, and TK varied from 0.8° to 5.0°, and the interrater SEM values ranged from 2.5° to 6.2°, depending on the parameter and the reading round. The I-IR SEM values for SVA varied from 2.2 to 5.7 mm and from 4.6 to 5.0 mm, respectively. Kappa values were >0.88 for all readers. The intrarater variability was the smallest for the most experienced rater. Conclusion: The I-IR of measuring sagittal spinopelvic parameters on digital full-spine images with basic software tools was high. Parameters consisting of several anatomic landmarks were more liable to error. Rater experience had a positive influence on reliability and repeatability. Reader experience should be assessed before accepting measurements for surgical planning and the interpretation of surgical correction during postoperative follow-up.
Role of carbonic anhydrases in skin wound healing
Harlan Barker,Marleena Aaltonen,Peiwen Pan,Maria Vähätupa,Pirkka Kaipiainen,Ulrike May,Stuart Prince,Hannele Uusitalo-Järvinen,Abdul Waheed,Silvia Pastoreková,William S Sly,Seppo Parkkila,Tero AH Järv 생화학분자생물학회 2017 Experimental and molecular medicine Vol.49 No.-
Skin wound closure occurs when keratinocytes migrate from the edge of the wound and re-epithelialize the epidermis. Their migration takes place primarily before any vascularization is established, that is, under hypoxia, but relatively little is known regarding the factors that stimulate this migration. Hypoxia and an acidic environment are well-established stimuli for cancer cell migration. The carbonic anhydrases (CAs) contribute to tumor cell migration by generating an acidic environment through the conversion of carbon dioxide to bicarbonate and a proton. On this basis, we explored the possible role of CAs in tissue regeneration using mouse skin wound models. We show that the expression of mRNAs encoding CA isoforms IV and IX are increased (~25 × and 4 × , respectively) during the wound hypoxic period (days 2–5) and that cells expressing CAs form a bandlike structure beneath the migrating epidermis. RNA-Seq analysis suggested that the CA IV-specific signal in the wound is mainly derived from neutrophils. Due to the high level of induction of CA IV in the wound, we treated skin wounds locally with recombinant human CA IV enzyme. Recombinant CA IV significantly accelerated wound re-epithelialization. Thus, CA IV could contribute to wound healing by providing an acidic environment in which the migrating epidermis and neutrophils can survive and may offer novel opportunities to accelerate wound healing under compromised conditions.