ROOM-TEMPERATURE SOLID-STATE REACTION TO TREE-LIKE FRACTAL NANO-CdS AND THIRD-ORDER NONLINEAR OPTICAL PROPERTIES

TAO-YU ZHOU,HUI WANG,XIAO-PING KANG,XIN-QUAN XIN 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2013 NANO Vol.8 No.4

A novel tree-like nano-cadmium sulfide (CdS) with the fractal feature is synthesized by solid-state reaction at room temperature from complex precursor with aminotrimethylenephosphonic acid (ATMP) as ligand. The obtained sample is the crystalline cubic beta cadmium sulfide. The tree is composed of nanorods with an average diameter of ca. 95 nm and a length of up to 100–650 nm. The nanorods grow in the asymmetrical "Y" shape. The amount of ATMP plays an important role in the formation of fractal structure. Nonlinear optical (NLO) measurements by the Z-scan technique exhibit that the tree-like fractal nano-CdS has the third-order nonlinear optical properties of both NLO absorption and NLO refraction with self-focusing effect and the optical limiting performance.

Metastasis associated genomic aberrations in stage II rectal cancer

Hong Zhao,Zhi-Zhou Shi,Rui Jiang,Dong-Bing Zhao,Hai-Tao Zhou,Jian-Wei Liang,Xin-Yu Bi,Jian-Jun Zhao,Zhi-Yu Li,Jian-Guo Zhou,Zhen Huang,Ye-Fan Zhang,Jian Wang,Xin Xu,Yan Cai,Ming-Rong Wang,Yu Zhang 한국유전학회 2016 Genes & Genomics Vol.38 No.11

Genomic aberrations of rectal carcinoma, especially DNA copy number changes associated with metastasis were largely unclear. We aim to identify the metastasis associated biomarkers in stage II rectal cancer. Formalin-fixed, paraffin-embedded primary tumor tissues of stage II rectal carcinoma were analyzed by array-based comparative genomic hybridization, and genomic aberrations were identified by Genomic Workbench and SAM software. Copy number changes and mRNA expressions were validated by Real-time PCR in an independent rectal cancer samples. The results showed that the most frequent gains in stage II rectal cancer were at 1q21.2-q23.1, 3p21.31, 11q12.2-q23.3, 12q24.11-q24.31, 12q13.11-q14.1 and losses in 18q11.2-q23, 17q21.33-q22, 13q31.1-q31.3, 21q21.1-q21.3, 8p23.3-p23.1 and 4q22.1-q23. Twenty-two amplifications and five homozygous deletions were also identified. We further found that S100A1 (1q21.3-q23.1), MCM7 (7q22.1) and JUND (19p13.11) were amplified and overexpressed in stage II rectal cancer. Interestingly, the genomic aberrations affected 14 signaling pathways including VEGF signaling pathway and fatty acid metabolism. Most importantly, loss of 13q31.1-q34 and gain of 1q44 were associated with distant metastasis. Our results indicated that these metastasis associated genomic changes may be useful to reveal the pathogenesis of rectal cancer metastasis and identify candidate biomarkers.

Norcantharidin Anti-Angiogenesis Activity Possibly through an Endothelial Cell Pathway in Human Colorectal Cancer

Yu, Tao,Hou, Fenggang,Liu, Manman,Zhou, Lihong,Li, Dan,Liu, Jianrong,Fan, Zhongze,Li, Qi Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.2

The present study was based on the unexpected discovery that norcantharidin exerted anti-angiogenesis activity when effects on growth of human colon cancer were studied. The aim was to further verify this finding and explore possible mechanisms using a tumor xenograft model in nude mice. We confirmed that norcantharidin (5 or 15 mg/kg) could inhibit angiogenesis of human colon cancer in vivo. In vitro, crossing river assay, cell adhesion assay and tube formation assay indicated that NCTD could reduce the migration, adhesion and vascular network tube formation ability of HUVECs. At the same time, the expression levels of VEGF and VEGFR-2 proteins which play important roles in angiogenesis were reduced as examined by western blotting analysis. Taken together, the results firstly showed NCTD could inhibit angiogenesis of human colon cancer in vivo, probably associated with effects on migration, adhesion and vascular network tube formation of HUVECs and expression levels of VEGF and VEGFR-2 proteins.

Facile synthesis of AgPt nano-pompons for efficient methanol oxidation: Morphology control and DFT study on stability enhancement

Tao Shao,Dehong Bai,Mingzhu Qiu,Yu Li,Qiankun Zhang,Ziyu Xue,Shijie He,Dongxia Zhang,Xibin Zhou 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.108 No.-

Facile synthesis of more dendritic and uniform Pt-based nanostructures with carbon materials couldgreatly reduce cost and increase Pt utilization for methanol oxidation reaction (MOR) in direct methanolfuel cell (DMFC). This study reports a novel one-pot method to fabricate AgPt nano-pompons (AgPt NPs)with the guidance of N-GQDs through AA reduce the precursor of Ag and Pt. Morphology characterizationdescribes N-GQDs as morphology guiding and dispersing agents to regulate the dendrite formation ofnano-pompons. Under the optimized conditions, the AgPt NPs (Ag1Pt2) display above 11 times improvementin electrocatalytic activity and higher stability for the MOR compared with Pt/C catalysts. Densityfunction theory (DFT) studies prove that the introduction of Ag can greatly enhance the adsorption of COon Pt and promote the transformation of CO to COOH. The facile synthetic method and excellent MORperformance endow AgPt NPs with great application prospect in DMFCs as an anode catalyst.

Flexural performance of fire damaged and rehabilitated two span reinforced concrete slabs and beams

Yu, Jiang-Tao,Liu, Yuan,Lu, Zhou-Dao,Xiang, Kai Techno-Press 2012 Structural Engineering and Mechanics, An Int'l Jou Vol.42 No.6

Five two-span reinforced concrete (RC) slabs and seven two-span RC beams were tested under the ISO 834 standard fire with different durations. CFRP strengthening was then applied to some of the specimens after the damaged concrete was removed from the specimens and replaced with polymer mortar. All the specimens were loaded to failure to investigate the influence of fire-damage and the effectiveness of strengthening methods. Test results indicated that the flexural capacities of specimens decrease with the fire duration increases. Moreover, fire exposure had more significant effect on the flexural rigidity than on the bearing capacity of the specimens. After rehabilitation, the bearing capacities of specimens reached or even exceeded that of the reference RC specimen, and the strengthening methods seemed to have limited effect on flexural rigidity recovery. From the analysis of moment redistribution of tested beams, elevated temperature is found having different impacts on sagging moment region and hogging moment region. The damage of RC continuous member is definitely a comprehensive response of different regions.

Diffusion mechanism of deep shale gas and its carbon isotope fractionation: a combined simulated and mathematical analysis

Yu Zou,Guojian Wang,Cheng Tao,Rui Zhou,Shangqing Zhang,Dongna Liu,Xiaohui Lin,Xuying Zheng 한국지질과학협의회 2023 Geosciences Journal Vol.27 No.3

Unlike the release pressure process in shale gas exploitation, in this study, the concentration diffusion process is deeply discussed under constant temperature-pressure conditions, which aims to evaluate the preservation conditions of shale gas reservoirs in combination with isotopic fractionation characteristics. The isobaric diffusion experiment emphasized that decreasing pressure can lead to enhanced diffusion and isotope fractionation. The established mathematical model not only confirms the results of the simulating experiment, but also suggests that the contributions of Fick, Knudsen and surface diffusion to the migration of methane (including 12CH4 and 13CH4) vary in the geological evolution of shale reservoirs, which are mainly controlled by the pore system and gas pressure. Based on the analysis of specific samples of Longmaxi shale (r = 11.7 nm) and Niutitang shale (r = 1.3 nm), we propose that: 1) high pressure condition (> 20 MPa) can significantly limit Knudsen diffusion, which is the reason for reducing the total diffusion coefficient (DTotal) and isotope fractionation, while low pressure (< 10 MPa) and small pore radius (ca. 1 nm) can strengthen the fractionation; 2) pore connectivity and heterogeneity can lead to an order of magnitude change in DTotal, while the influence of temperature is relatively small. According to the mathematical model, it can be expected that enhanced dissipation intensity and isotope fractionation of shale gas may occur in the process of basin uplift and pressure relief, which can potentially be used for the evaluation of reservoir preservation.

Triptolide Inhibits Proliferation and Induces Apoptosis of Human Melanoma A375 Cells

Tao, Yue,Zhang, Meng-Li,Ma, Peng-Cheng,Sun, Jian-Fang,Zhou, Wu-Qing,Cao, Yu-Ping,Li, Ling-Jun Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.4

Triptolide, a diterpenoid obtained from Tripteryglum wilfordii Hook.f, has attracted interest for its antitumor activities against human tumor cell lines in recent years. This report focuses on anti-proliferative and pro-apoptotic activities in human melanoma A375 cells assessed by CCK8 assay, Hoechst 33258 staining and flow cytometry. In addition, triptolide-induced arrest in the S phase was also observed. Caspase assays showed the apoptosis induced by triptolide was caspase-dependent and probably through intrinsic apoptotic pathways. Furthermore, expression of NF-${\kappa}B$ (p65) and its downstream factors such as Bcl-2, Bcl-$X_L$ was down-regulated. Taken together, the data indicate that triptolide inhibits A375 cells proliferation and induces apoptosis by a caspase-dependent pathway and through a NF-${\kappa}B$-mediated mechanism.

Protective Effect of Ginsenoside R0 on Anoxic and Oxidative Damage In vitro

( Zhou Jiang ),( Yu Hui Wang ),( Xiao Yun Zhang ),( Tao Peng ),( Yan Qing Li ),( Yi Zhang ) 한국응용약물학회 2012 Biomolecules & Therapeutics(구 응용약물학회지) Vol.20 No.6

To examine the neuroprotective effects of ginsenoside R0, we investigated the effects of ginsenoside R0 in PC12 cells under an anoxic or oxidative environment with Edaravone as a control. PC12 neuroendocrine cells were used as a model target. Anoxic damage or oxidative damage in PC12 cells were induced by adding sodium dithionite or hydrogen peroxide respectively in cul-tured medium. Survival ratios of different groups were detected by an AlamarBlue assay. At the same time, the apoptosis of PC12 cells were determined with flow cytometry. The putative neuroprotective effects of ginsenoside R0 is thought to be exerted through enhancing the activity of antioxidant enzymes Superoxide dismutases (SOD). The activity of SOD and the level of malondialde-hyde (MDA) and intracellular reactive oxygen species (ROS), were measured to evaluate the protective and therapeutic effects of ginsenoside R0. Ginsenoside R0 treated cells had a higher SOD activity, lower MDA level and lower ROS, and their survival ratio was higher with a lower apoptosis rate. It is suggested that ginsenoside R0 has a protective effect in the cultured PC12 cells, and the protection efficiency is higher than Edaravone. The protective mechanisms of these two are different. The prevent ability of ginsenoside R0 is higher than its repair ability in neuroprotection in vitro.

Enhanced adsorption of fluoride from aqueous solutions by hierarchically structured Mg-Al LDHs/Al2O3 composites

Tao Zhang,Hanqiang Yu,Yuming Zhou,Jian Rong,Zhanyu Mei,Fengxian Qiu 한국화학공학회 2016 Korean Journal of Chemical Engineering Vol.33 No.2

Hierarchically structured layered double hydroxides (LDHs)/Al2O3 composites were fabricated from waste paper fibers using a two-step method. In the first step microscaled Al2O3 fibers were prepared by template-directed synthesis employing waste paper fibers as templates; and in the second step nanoscaled LDHs platelets were fabricated into hierarchical architectures based on crystal growth on Al2O3 fibers surface. The morphology and structure of asprepared samples were characterized by scanning electron microscopy (SEM), N2 adsorption/desorption analysis and X-ray diffraction (XRD) analysis. The SEM results revealed that the inorganic fibers were covered by LDHs platelets, forming the hierarchical structures with micro- to nanoscales. The BET analysis showed that the surface area was increased from 76.66m2/g (Al2O3 fibers) to 165.0m2/g (composites) by the growth of LDHs platelets on the surfaces of Al2O3 fibers. As compared to bare LDHs particles and Al2O3 fibers, the LDHs/Al2O3 composites show a high fluoride adsorption capacity, and the maximum adsorption capacity can reach up to 58.7mg/g. The Langmuir isotherm model was found to agree well with the equilibrium data, while the pseudo-second order model provided the highest correlation of the kinetic data for fluoride adsorption. The as-prepared LDHs/Al2O3 composites and corresponding design strategies developed herein are expected to be applicable to the synthesis of other LDHs based composites for the removal of pollutants from water.

Systematic Review and Meta-Analysis of Antibiotic-Impregnated Shunt Catheters on Anti-Infective Effect of Hydrocephalus Shunt

Zhou, Wen-xiu,Hou, Wen-bo,Zhou, Chao,Yin, Yu-xia,Lu, Shou-tao,Liu, Guang,Fang, Yi,Li, Jian-wen,Wang, Yan,Liu, Ai-hua,Zhang, Hai-jun The Korean Neurosurgical Society 2021 Journal of Korean neurosurgical society Vol.64 No.2

Objective : Shunt infection is a common complication while treating hydrocephalus. The antibiotic-impregnated shunt catheter (AISC) was designed to reduce shunt infection rate. A meta-analysis was conducted to study the effectiveness of AISCs in reduction of shunt infection in terms of age, follow-up time and high-risk patient population. Methods : This study reviewed literature from three databases including PubMed, EMBASE, and Cochrane Library (from 2000 to March 2019). Clinical studies from controlled trials for shunt operation were included in this analysis. A subgroup analysis was performed based on the patient's age, follow-up time and high-risk population. The fixed effect in RevMan 5.3 software (Cochrane Collaboration) was used for this meta-analysis. Results : This study included 19 controlled clinical trials including 10105 operations. The analysis demonstrated that AISC could reduce the infection rate in shunt surgery compared to standard shunt catheter (non-AISC) from 8.13% to 4.09% (odds ratio [OR], 0.48; 95% confidence interval [CI], 0.40-0.58; p=0.01; I2=46%). Subgroup analysis of different age groups showed that AISC had significant antimicrobial effects in all three groups (adult, infant, and adolescent). Follow-up time analysis showed that AISC was effective in preventing early shunt infections (within 6 months after implant). AISC is more effective in high-risk population (OR, 0.24;95% CI, 0.14-0.40; p=0.60; I2=0%) than in general patient population. Conclusion : The results of meta-analysis indicated that AISC is an effective method for reducing shunt infection. We recommend that AISC should be considered for use in infants and high-risk groups. For adult patients, the choice for AISC could be determined based on the treatment cost.