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Phan, T.L.,Dang, N.T.,Ho, T.A.,Manh, T.V.,Thanh, T.D.,Jung, C.U.,Lee, B.W.,Le, A.T.,Phan, A.D.,Yu, S.C. Elsevier Sequoia 2016 Journal of alloys and compounds Vol.657 No.-
We have prepared polycrystalline samples La<SUB>0.7</SUB>Ca<SUB>0.3-x</SUB>Ba<SUB>x</SUB>MnO<SUB>3</SUB> (x = 0, 0.025, 0.05, 0.075 and 0.1) by solid-state reaction, and then studied their magnetic properties and magnetocaloric (MC) effect based on magnetization versus temperature and magnetic-field (M-H-T) measurements. Experimental results reveal the easiness in tuning the Curie temperature (T<SUB>C</SUB>) from 260 to about 300 K by increasing Ba-doping concentration (x) from 0 to 0.1. Under an applied field H = 50 kOe, maximum magnetic-entropy changes around T<SUB>C</SUB> of the samples can be tuned in the range between 6 and 11 J kg<SUP>-1</SUP> K<SUP>-1</SUP>, corresponding to refrigerant-capacity values ranging from 190 to 250 J kg<SUP>-1</SUP>. These values are comparable to those of some conventional MC materials, and reveal the applicability of La<SUB>0.7</SUB>Ca<SUB>0.3-x</SUB>Ba<SUB>x</SUB>MnO<SUB>3</SUB> materials in magnetic refrigeration. Analyses of the critical behavior based on the Banerjee criteria, Arrott plots and scaling hypothesis for M-H-T data prove a magnetic-phase separation when Ba-doping concentration changes. In the doping region x = 0.05-0.075, the samples exhibits the crossover of first- and second-order phase transitions with the values of critical exponents β and γ close to those expected for the tricritical mean-field theory. The samples with x < 0.05 and x > 0.075 exhibit first- and second-order transitions, respectively. More detailed analyses related to the Griffiths singularity, the critical behavior for different magnetic-field intervals started from 10 kOe, and the magnetic-ordering parameter n = dLn|ΔS<SUB>m</SUB>|/dLnH (where ΔS<SUB>m</SUB> is the magnetic-entropy change) demonstrate magnetic inhomogeneities and multicritical phenomena existing in the samples.
Le, T.D.,Kim, J.H.,Hyeon, C.J.,Kim, D.K.,Yoon, Y.S.,Lee, J.,Park, Y.G.,Jeon, H.,Quach, H.L.,Kim, H.M. The Korea Institute of Applied Superconductivity a 2016 한국초전도저온공학회논문지 Vol.18 No.4
The high temperature superconducting (HTS) contra-rotating propulsion (CRP) systems comprise two coaxial propellers sited on behind the other and rotate in opposite directions. They have the hydrodynamic advantage of recovering the slipstream rotational energy which would otherwise be lost to a conventional single-screw system. However, the cooling systems used for HTS CRP system need a high cooling power enough to maintain a low temperature of 2G HTS material operating at liquid neon (LNe) temperature (24.5 - 27 K). In this paper, a single thermo-syphon cooling approach using a Gifford-McMahon (G-M) cryo-cooler is presented. First, an optimal thermal design of a 1.5 MW HTS motor was conducted varying to different types of commercial 2G HTS tapes. Then, a mono-cryogenic cooling system for an integration of two 1.5 MW HTS motors will be designed and analyzed. Finally, the 3D finite element analysis (FEA) simulation of thermal characteristics was also performed.
Le, T.D.,Kim, J.H.,Park, S.I.,Kim, D.J.,Lee, H.G.,Yoon, Y.S.,Jo, Y.S.,Yoon, K.Y.,Kim, H.M. The Korea Institute of Applied Superconductivity a 2014 한국초전도저온공학회논문지 Vol.16 No.4
To minimize most heat loss of current lead for high-temperature superconducting (HTS) rotating machine, the choice of conductor properties and lead geometry - such as length, cross section, and cooling surface area - are one of the various significant factors must be selected. Therefore, an optimal lead for large scale of HTS rotating machine has presented before. Not let up with these trends, this paper continues to improve of diminishing heat loss for HTS part according to different model. It also determines the simplification conditions for an evaluation of the main flux flow loss and eddy current loss transient characteristics during charging and discharging period.
RGD Conjugated Dendritic Polylysine for Cellular Delivery of Antisense Oligonucleotide
Le, T. D.,Nakagawa, O.,Fisher, M.,Juliano, R. L.,Yoo, H. American Scientific Publishers 2017 Journal of Nanoscience and Nanotechnology Vol.17 No.4
<P>Dendritic polylysines (DPL) are highly branched nano-sized spherical polymer with positively charged primary amino groups on surface. This structural feature is useful for a delivery of antisense oligonucleotide or siRNA. In this study, we modified the surface of DPL with cyclic RGD (and iRGD) peptide by conjugation reaction generating RGD (and iRGD) peptide conjugated dendritic poly-lysines, RGD-DPL or iRGD-DPL. The prepared conjugates were evaluated for integrin receptor-mediated cellular delivery of antisense oligonucleotide. The conjugation of RGD or iRGD peptide on DPL was monitored by measuring the retention time in capillary zone electrophoresis and the absorbance at UV-Vis spectroscopy. Cellular delivery by DPL-RGD (or -iRGD)/antisense oligonucleotide complex was examined by antisense splicing correction assay on integrin alpha v/beta 3 positive A375B3-Luc cells, which were stably transfected with plasmid pLuc/705. DPL-RGD (or -iRGD)/antisense oligonucleotide complexes exhibited integrin receptor mediated uptake on A375B3 cells without inducing cellular toxicity. In addition, the delivery of antisense oligonucleotide was integrin receptor-dependent with moderate efficiency.</P>
Le, T.K.,Jang, H.H.,Nguyen, H.T.H.,Doan, T.T.M.,Lee, G.Y.,Park, K.D.,Ahn, T.,Joung, Y.H.,Kang, H.S.,Yun, C.H. IPC Science and Technology Press ; Elsevier Scienc 2017 Enzyme and microbial technology Vol.97 No.-
<P>Enzymatic conversion of natural glycosides to their corresponding hydroxylated products using cytochromes P450 has significant advantages over synthetic chemistry and even enzyme-catalyzed glycosylation of chemicals. At present, the basic strategy for making glycosides of stilbenoid compounds is to use the glycosylation activity of enzymes, such as glycosyltransferases. Here, an efficient synthesis of a valuable (E)-astringin, a piceatannol glucoside, was developed using CYP102A1 via the highly regioselective C-3' hydroxylation of polydatin, a resveratrol glucoside. (E)-astringin is a high added value compound found in plants and wine. Benzylic hydroxylation of polydatin provides an attractive route to (E)-astringin, a catechol product. Thus far, chemical and enzymatic methods of producing (E)-astringin have not been developed. In the present study, a set of CYP102A1 mutants from Bacillus megaterium was found to catalyze regioselective hydroxylation of polydatin at the C-3' position to generate an (E)-astringin, a piceatannol glucoside. (C) 2016 Elsevier Inc. All rights reserved.</P>
Le, M. T.,Choi, H.,Choi, M.‐,K.,Nguyen, D. T.,Kim, J.‐,H.,Seo, H. G.,Cha, S.‐,Y.,Seo, K.,Chun, T.,Schook, L. B.,Park, C. Munksgaard 2012 Tissue antigens Vol.80 No.6
<P><B>Abstract</B></P><P>We previously reported the development of genomic‐DNA‐based high‐resolution genotyping methods for SLA‐DQB1 and DRB1. Here, we report the successful typing of SLA‐DQA using similar methodological principles. We designed a method for comprehensive genotyping of SLA‐DQA using intronic sequence information of SLA‐DQA exon 2 that we had obtained from 12 animals with different SLA‐DQB1 genotypes. We expanded our typing to 76 selected animals with diverse DQB1 and DRB1 genotypes, 140 random animals from 7 pig breeds, and 3 wild boars. This resulted in the identification of 17 DQA alleles with 49 genotypes. Two new alleles were identified from wild boars. Combine with SLA‐DQB1, and DRB1 typing results, we identified 34 SLA class II haplotypes including 25 that were previously unreported.</P>
Status of the technology development of large scale HTS generators for wind turbine
Le, T.D.,Kim, J.H.,Kim, D.J.,Boo, C.J.,Kim, H.M. The Korea Institute of Applied Superconductivity a 2015 한국초전도저온공학회논문지 Vol.17 No.2
Large wind turbine generators with high temperature superconductors (HTS) are in incessant development because of their advantages such as weight and volume reduction and the increased efficiency compared with conventional technologies. In addition, nowadays the wind turbine market is growing in a function of time, increasing the capacity and energy production of the wind farms installed and increasing the electrical power for the electrical generators installed. As a consequence, it is raising the wind power energy contribution for the global electricity demand. In this study, a forecast of wind energy development will be firstly emphasized, then it continue presenting a recent status of the technology development of large scale HTSG for wind power followed by an explanation of HTS wire trend, cryogenics cooling systems concept, HTS magnets field coil stability and other technological parts for optimization of HTS generator design - operating temperature, design topology, field coil shape and level cost of energy, as well. Finally, the most relevant projects and designs of HTS generators specifically for offshore wind power systems are also mentioned in this study.