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RISS 인기검색어
- 검색키워드
- 저자 : Supaporn Muchimapura (검색결과 3 건)
- 무료
- 기관 내 무료
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Laser Acupuncture Improves Memory Impairment in an Animal Model of Alzheimer’s Disease
Chatchada Sutalangka,Jintanaporn Wattanathorn,Supaporn Muchimapura,Wipawee Thukham-mee,Panakaporn Wannanon,Terdthai Tong-un 사단법인약침학회 2013 Journal of Acupuncture & Meridian Studies Vol.6 No.5
The burden of Alzheimer’s disease is continually rising globally, especially in the Asia-Pacific region. Unfortunately, the efficacy of the therapeutic strategy is still very limited. Because the effect of acupuncture at HT7 can improve learning and memory, the beneficial effect of laser acupuncture, a noninvasive form of acupuncture, at HT7 on memory improvement in patients with Alzheimer’s disease has been a focus of research. To elucidate this issue, we used AF64A, a cholinotoxin, to induce memory impairment in male Wistar rats, which weighed 180e220 g. Then, the animals were treated with laser acupuncture either at HT7 or at a sham acupoint once daily for 10 minutes for a period of 14 days. Spatial memory assessments were performed at 1, 7, and 14 days after AF64A administration and at the end of the experiment, and the changes in the malondialdehyde (MDA) level and in the superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), and acetylcholinesterase (AChE) activities in the hippocampus were recorded. The results showed that laser acupuncture significantly suppressed AChE activity in the hippocampus. Although laser acupuncture enhanced SOD and CAT activities, no reduction in MDA level in this area was observed. Therefore, laser acupuncture at HT7 is a potential strategy to attenuate memory impairment in patients with Alzheimer’s disease. However, further research, especially on the toxicity of laser acupuncture following repetitive exposure, is essential.
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Purple Rice Berry Is Neuroprotective and Enhances Cognition in a Rat Model of Alzheimer's Disease
Wanassanun Pannangrong,Jintanaporn Wattanathorn,Supaporn Muchimapura,Somsak Tiamkao,Terdthai Tong-un 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.7
Alzheimer's disease, a neurodegenerative disease characterized by progressive memory loss and cognitive impairment, is the most common type of dementia in aging populations due to severe loss of cholinergic neurons in a specific area. Oxidative stress is known to be involved in the pathogenesis of this condition. Therefore, the cognition-enhancing and neuroprotective effects of rice berry (Oryza sativa), a purple-pigmented rice that is rich in antioxidant substances, was evaluated. Young adult male Wistar rats, weighing 180–220 g, were orally given rice berry once daily at doses of 180, 360, and 720 mg/kg of body weight for a period of 2 weeks before and 1 week after the induction of memory deficit and cholinergic lesions with AF64A, a specific cholinotoxin, via bilateral intracerebroventricular administration. One week following AF64A administration the rats were evaluated for spatial memory, neuron density, acetylcholinesterase activity, and hippocampal lipid peroxidation products. Our results showed that rice berry could significantly prevent memory impairment and hippocampal neurodegeneration in hippocampus. Moreover, it also decreased hippocampal acetylcholinesterase activity and lipid peroxidation product formation. These results suggest that rice berry has potential as an effective agent for neurodegeneration and memory impairment in Alzheimer's disease.
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Jintanaporn Wattanathorn,Nattaporn Phunchago,Kowit Chaisiwamongkol,Supaporn Muchimapura,Wipawee Thukham-mee 사단법인약침학회 2015 Journal of Acupuncture & Meridian Studies Vol.8 No.1
Currently, the therapeutic strategy against memory deficit induced by alcoholism is not satisfactory and is expensive. Therefore, an effective, cheap strategy is required. On the basis of the memory-enhancing effect of stimulation of the HT7 acupoint, we aimed to determine whether acupuncture at the HT7 acupoint can reduce alcoholism-induced memory impairment. The possible underlying mechanism was also explored. Alcoholism was induced in male Wistar rats weighing 180-220 g. The alcoholic rats received either acupuncture at HT7 or sham acupuncture for 1 minute bilaterally once daily for 14 days. Their spatial memory was assessed after 1, 7 and 14 days of treatment. At the end of the study, the malondialdehyde (MDA) level and the activities of catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and acetylcholinesterase (AChE) enzymes in the hippocampus were determined using colorimetric assays. The results showed that acupuncture at HT7 significantly decreased the AChE activity and the MDA level, but increased the activities of CAT, SOD and GSH-Px in the hippocampus. These results suggest that acupuncture at HT7 can effectively reduce the alcoholism-induced memory deficit. However, further studies concerning the detailed relationships between the location of the HT7 acupoint and the changes in the observed parameters are required.
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