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RISS 인기검색어
- 검색키워드
- 저자 : Sunita Mishra (검색결과 5 건)
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Curcumin Induces Apoptosis in Pre-B Acute Lymphoblastic Leukemia Cell Lines Via PARP-1 Cleavage
Mishra, Deepshikha,Singh, Sunita,Narayan, Gopeshwar Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.8
Curcumin, a polyphenolic compound isolated from the rhizomes of an herbaceous perennial plant, Curcuma longa, is known to possess anticancerous activity. However, the mechanism of apoptosis induction in cancers differs. In this study, we have (1) investigated the anticancerous activity of curcumin on REH and RS4;11 leukemia cells and (2) studied the chemo-sensitizing potential of curcumin for doxorubicin, a drug presently used for leukemia treatment. It was found that curcumin induced a dose dependent decrease in cell viability because of apoptosis induction as visualized by annexin V-FITC/ PI staining. Curcumin-induced apoptosis of leukemia cells was mediated by PARP-1 cleavage. An increased level of caspase-3, apoptosis inducing factor (AIF), cleaved PARP-1 and decreased level of Bcl2 was observed in leukemia cells after 24h of curcumin treatment. In addition, curcumin at doses lower than the $IC_{50}$ value significantly enhanced doxorubicin induced cell death. Therefore, we conclude that curcumin induces apoptosis in leukemia cells via PARP-1 mediated caspase-3 dependent pathway and further may act as a potential chemo-sensitizing agent for doxorubicin. Our study highlights the chemo-preventive and chemo-sensitizing role of curcumin.
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Saurabh Gupta,Vinod Kumar Mishra,Sunita Kumari,Raavi,Ramesh Chand,Pritish Kumar Varadwaj 한국유전학회 2019 Genes & Genomics Vol.41 No.1
WRKY transcription factors (TFs) act in regulating plant growth and development as well as in response to different stress. Some earlier studies done by individual researchers reported different wheat WRKY TFs. Although, the recently released wheat genome has opened an avenue to investigate wheat WRKYs (TaWRKY) TFs. Prime objective of this study to performed genome-wide classifications of TaWRKYs and their functional annotation. The classification of 107 individual identified characterized sequences of TaWRKY (IICS-TaWRKY) and 160 uncharacterized draft sequences of TaWRKY (UDS-TaWRKY), along with their gene structures and motifs analysis was performed. Along with comparative sequence analysis and microarray analysis was performed to mimic out TaWRKYs functions in response to different abiotic stresses, accompanied by in-vitro validation. The comparative phylogenetic analysis and estimation of Ka/Ks ratio with Triticum urartu, illustrate group based clasifications of TaWRKYs and evolutionary divergences. Furthermore, motif-based and protein-DNA interaction analysis of TaWRKYs helps to identify, their putative function in target DNA recognition sites. Subsequently, results of microarray and comparative sequence analysis provides the evidence of TaWRKYs involved in heat and/or drought stress. Further, in-vitro results validates that TaWRKY014, TaWRKY090 are found to participate in response of drought stress, whereas TaWRKY008, TaWRKY122, and WRKY45 are involved in response of heat and drought stress. These findings can be utilized in developing novel heat and drought-tolerant wheat cultivars using marker-assisted breeding and transgenic development.
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Sundriyal, Shashank,Kaur, Harmeet,Bhardwaj, Sanjeev Kumar,Mishra, Sunita,Kim, Ki-Hyun,Deep, Akash Elsevier 2018 Coordination chemistry reviews Vol.369 No.-
<P><B>Abstract</B></P> <P>Metal-organic frameworks (MOFs) belong to a novel class of materials with several advantages (e.g., ultrahigh porosity, tunable pore size distribution, convenience of synthesis, and structural tailor-ability). However, the insulating nature of MOFs is often recognized as a limiting factor in the extension of their applications, especially in electronic fields. In light of such limitations, various functional or conductive materials have been mixed/intercalated with MOFs to improve their potential for such applications (e.g., rechargeable batteries, optoelectronics, and supercapacitors). Lately, many of these composite materials have been recognized as next-generation electrodes for the development of efficient supercapacitors. In this review article, we have critically reviewed the recent advancements in supercapacitor applications of MOFs and their derived composite structures. Further, we have also discussed the application of various categories of electrolytes (e.g., aqueous, organic, ionic liquids, solid-state, and redox electrolytes) and their impacts on the development of MOF-based supercapacitors.</P> <P><B>Highlights</B></P> <P> <UL> <LI> State of the art information on the applications of MOF-based supercapacitor is explored. </LI> <LI> Recent advances in MOF-based supercapacitor applications have also been discussed. </LI> <LI> The role of electrolytes in the MOF-electrodes for supercapacitors has been discussed. </LI> <LI> Performance of MOF-composites is reviewed in terms of important supercapacitor parameters. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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Sadashiv,Anupama Modi,Manoj Khokhar,Praveen Sharma,Rajnish Joshi,Sudhanshu Shekhar Mishra,Rajay N Bharshankar,Sunita Tiwari,Pankaj Kumar Singh,Vivek Vidyadhar Bhosale,Mahendra Pal Singh Negi 대한비만학회 2021 The Korean journal of obesity Vol.30 No.3
Background: It is well established that obesity is a major health risk in diabetes and associated diseases. Epigenetic changes, specially DNA methylation, play an important role in regulation of adipokines. The objective of the present study was to evaluate the DNA methylation status at the promoter region of the leptin gene in obese individuals and its association with metabolic risk factors. Methods: The study included obese (n=100) and non-obese (n=75) individuals aged 25–45 years, and measured their physical, biochemical parameters (glucose, insulin, and lipid profiles) and leptin, DNA methyltransferase 1 (DNMT1), and DNA methyltransferase 3 beta (DNMT3b) mRNA expressions with real-time reverse transcription-polymerase chain reaction (qRT-PCR). DNA methylation of the leptin gene at the promoter region was analyzed by methyl-specific qPCR . Results: The study found that the DNA methylation level at the promoter area of the leptin gene was negatively associated with weight in obese subjects. Furthermore, study findings showed that the DNA methylation level was negatively associated with fasting insulin, glucose, homeostatic model assessment for insulin resistance, and total cholesterol. There was also a higher expression of DNMT1 and DNMT-3b in obese subjects as compared with non-obese subjects. Conclusion: The leptin epigenetic profile may be associated with obesity and its associated metabolic risk factors.
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