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Park, Jinbong,Jeon, Yong-Deok,Kim, Hye-Lin,Lim, Hara,Jung, Yunu,Youn, Dong-Hyun,Jeong, Mi-Young,Kim, Hyun-Ju,Kim, Sung-Hoon,Kim, Su-Jin,Hong, Seung-Heon,Um, Jae-Young Hindawi Publishing Corporation 2013 Evidence-based Complementary and Alternative Medic Vol.2013 No.-
<P>Obesity has become a major health threat in developed countries. However, current medications for obesity are limited because of their adverse effects. Interest in natural products for the treatment of obesity is thus rapidly growing. Korean Medicine (KM) is characterized by the wide use of herbal formulas. However, the combination rule of herbal formulas in KM lacks experimental evidence. According to <I>Shennong's Classic of Materia Medica</I>, the earliest book of herbal medicine, <I>Veratrum nigrum</I> (VN) has antagonistic features against <I>Panax ginseng</I> (PG), and the PG-VN pair is strictly forbidden. In this study, we have shown the effects of PG, VN, and their combination on obesity in high-fat (HF) diet-induced obese mice and in 3T3-L1 cells. PG, VN, and PG-VN combination significantly reduced weight gain and the fat pad weight in HF diet-induced obese mice. They also significantly decreased lipid accumulation and the expressions of two major adipogenesis factors, PPAR<I><I>γ</I></I> and C/EBP<I><I>α</I></I>, in 3T3-L1 cells. In addition, the PG-VN combination had synergistic effects compared with the mixture of extracts of PG and VN on inhibition of PPAR<I><I>γ</I></I> and C/EBP<I><I>α</I></I> expressions at lower doses. These results indicate a new potential anti-obese pharmacotherapy and also provide scientific evidence supporting the usage of herbal combinations instead of mixtures in KM.</P>
공동주택 주차장의 축적먼지 중 미량원소성분 분석과 오염원 평가
배건호(Gun Ho Bae),정철수(Cheol Su Jung),박규태(Kyu Tae Park),이명숙(Myoung Sook Lee),신동찬(Dong Chan Shin),김용혜(Yong Hye Kim),윤민혜(Min Hye Yoon),한영진(Young Jin Han),최혁(Hyuek Choi),백성옥(Sung Ok Baek) 大韓環境工學會 2011 대한환경공학회지 Vol.33 No.10
공동주택 주차장의 먼지오염실태를 연구하기 위하여 2010년 3월말에서 6월초까지 대구지역 공동주택 36곳의 지상주차장(36지점)과 지하주차장(36지점)을 대상으로 채취한 총 72개의 시료를 100 μm 이하로 체거름하고 산추출한 후 ICP로 14개원소를 분석하였다. 농축계수를 이용한 미량원소성분의 발생원 평가결과는 지상주차장과 지하주차장 모두 Fe, K, Mg, Mn, Na, V의 성분은 자연적인 발생원에 의한 영향을 받고 있는 반면에 Cd, Cr, Cu, Ni, Pb, Zn의 성분은 인위적인 발생원에 의한 영향을 받고 있는 것으로 나타났다. 한편 Ca은 지상주차장의 경우에는 자연적인 발생원의 영향을 받았고, 지하주차장의 경우에는 인위적인 발생원의 영향을 받은 것으로 나타났다. 미량원소성분의 농도분석 결과는 자연적인 발생원과 관련된 성분이 인위적인 발생원과 관련된 성분보다 매우 높은 농도를 보였다. 인위적인 발생원성분의 기여도는 지하주차장이 지상주차장보다 높았으며, 미량원소성분의 평균농도 또한 지하주차장이 지상주차장보다 높았다. 오염지수를 이용한 중금속성분의 오염도를 평가한결과는 지하주차장이 지상주차장보다 5.5배정도 높게 오염된 것으로 나타났다. 미량원소성분간의 상관성 분석결과는 지상주차장이 지하주차장에 비해 유의한 상관성을 나타내는 항목이 많았으며, 특히 자연적 발생원 성분간 유의한 상관성이 더욱 크게 나타났다. 또한 유해 중금속성분과 지하주차장의 영향인자간의 상관성을 분석한 결과는 주차대수(공간)가 적은 지점이 큰 지점보다, 환기장치를 가동하지 않은 지점이 가동한 지점보다, 그리고 최근 도색년도와 청소일이 오래된 지점이 상대적으로 유해중금속을 많이 함유하고 있었다. In order to investigate the degree of apartment parking lot dust contamination, total 72 samples of parking lot dust (36 from ground parking lots and 36 from the underground parking lots) were collected in Daegu city from the end of March to the early June 2010. The dust samples were sieved below 100 μm, and analysed by ICP for 14 elements after an acid extraction. Results obtained from the source assessment of trace element using enrichment factor showed that Fe, K, Mg, Mn, Na and V were influenced by natural sources, while Cd, Cr, Cu, Ni, Pb and Zn were influenced by anthropogenic sources in both the ground parking lot and the underground parking lot. And results showed that Ca were influenced by natural sources in the ground parking lot, but influenced by anthropogenic sources in the underground parking lot. The measured values were remarkably higher in components from natural sources than in components from anthropogenic sources. Underground parking lot dust was more affected by anthropogenic sources and contaminated compared with the ground parking lot dust. Pollution index of heavy metals revealed that underground parking lot dust was 5.5 times more contaminated with heavy metal components than the ground parking lot dust. The results of correlation analysis among trace elements indicated that components in the ground parking lot were more correlated than those in the underground parking lot, and especially more correlated with natural sources-natural sources. Analysis for correlations between components and influencing factors in the underground parking lot showed that concentrations of heavy metals were higher with smaller number of parking spaces and no ventilation system, and older apartments in last paint and cleaning had relatively higher contents of heavy metals than those of recently painted and cleaned.
( Su Yeong Park ),( Min Gyu Kong ),( Inki Moon ),( Hyun Woo Park ),( Hyung-oh Choi ),( Hye Sun Seo ),( Yoon Haeng Cho ),( Nae-hee Lee ),( Kwan Yong Lee ),( Ho-jun Jang ),( Je Sang Kim ),( Ik Jun Choi 대한내과학회 2023 The Korean Journal of Internal Medicine Vol.38 No.5
Background/Aims: We aimed to analyze the efficacy of angiotensin receptor-neprilysin inhibitor (ARNI) by the disease course of heart failure (HF). Methods: We evaluated 227 patients with HF in a multi-center retrospective cohort that included those with left ventricular ejection fraction (LVEF) ≤ 40% undergoing ARNI treatment. The patients were divided into patients with newly diagnosed HF with ARNI treatment initiated within 6 months of diagnosis (de novo HF group) and those who were diagnosed or admitted for HF exacerbation for more than 6 months prior to initiation of ARNI treatment (prior HF group). The primary outcome was a composite of cardiovascular death and worsening HF, including hospitalization or an emergency visit for HF aggravation within 12 months. Results: No significant differences in baseline characteristics were reported between the de novo and prior HF groups. The prior HF group was significantly associated with a higher primary outcome (23.9 vs. 9.4%) than the de novo HF group (adjusted hazard ratio 2.52, 95% confidence interval 1.06-5.96, p = 0.036), although on a higher initial dose. The de novo HF group showed better LVEF improvement after 1 year (12.0% vs 7.4%, p = 0.010). Further, the discontinuation rate of diuretics after 1 year was numerically higher in the de novo group than the prior HF group (34.4 vs 18.5%, p = 0.064). Conclusions: The de novo HF group had a lower risk of the primary composite outcome than the prior HF group in patients with reduced ejection fraction who were treated with ARNI.
Park, Jin Sup,Cha, Kwang Soo,Lee, Dae Sung,Shin, Donghun,Lee, Hye Won,Oh, Jun-Hyok,Kim, Jeong Su,Choi, Jung Hyun,Park, Yong Hyun,Lee, Han Cheol,Kim, June Hong,Chun, Kook-Jin,Hong, Taek Jong,Jeong, Myu BMJ Publishing Group Ltd 2015 Heart Vol.101 No.15
<P><B>Objective</B></P><P>The value of multivessel revascularisation in cardiogenic shock and multivessel disease (MVD) is still not clear. We compared outcomes following culprit vessel or multivessel revascularisation in patients with ST-elevation myocardial infarction (STEMI), cardiogenic shock and MVD.</P><P><B>Methods</B></P><P>From 16 620 patients with STEMI who underwent primary percutaneous coronary intervention (PCI) in a nationwide, prospective, multicentre registry between January 2006 and December 2012, 510 eligible patients were selected and divided into culprit vessel revascularisation (n=386, 75.7%) and multivessel revascularisation (n=124, 24.3%) groups. The primary outcomes were inhospital mortality and all-cause death during a median 194-day follow-up. A weighted Cox regression model was constructed to determine the HRs and 95% CIs for outcomes in the two groups.</P><P><B>Results</B></P><P>Compared with culprit vessel revascularisation, multivessel revascularisation had a significantly lower adjusted risk of inhospital mortality (9.3% vs 2.4%, HR 0.263, 95% CI 0.149 to 0.462, p<0.001) and all-cause death (13.1% vs 4.8%, HR 0.400, 95% CI 0.264 to 0.606, p<0.001), mainly because of fewer cardiac deaths (9.7% vs 4.8%, HR 0.510, 95% CI 0.329 to 0.790, p=0.002). In addition, multivessel revascularisation significantly decreased the adjusted risk of the composite endpoint of all-cause death, recurrent myocardial infarction and any revascularisation (20.3% vs 18.1%, HR 0.728, 95% CI 0.55 to 0.965, p=0.026).</P><P><B>Conclusions</B></P><P>This study showed that, compared with culprit vessel revascularisation, multivessel revascularisation at the time of primary PCI was associated with better outcomes in patients with STEMI with cardiogenic shock. Our results support the current guidelines regarding revascularisation in these patients.</P>
High-performance reconfigurable coincidence counting unit based on a field programmable gate array
Park, Byung Kwon,Kim, Yong-Su,Kwon, Osung,Han, Sang-Wook,Moon, Sung The Optical Society 2015 Applied Optics Vol.54 No.15
<P>We present a high-performance reconfigurable coincidence counting unit (CCU) using a low-end field programmable gate array (FPGA) and peripheral circuits. Because of the flexibility guaranteed by the FPGA program, we can easily change system parameters, such as internal input delays, coincidence configurations, and the coincidence time window. In spite of a low-cost implementation, the proposed CCU architecture outperforms previous ones in many aspects: it has 8 logic inputs and 4 coincidence outputs that can measure up to eight-fold coincidences. The minimum coincidence time window and the maximum input frequency are 0.47??ns and 163??MHz, respectively. The CCU will be useful in various experimental research areas, including the field of quantum optics and quantum information.</P>
Park, In-Su,Kim, Ok-Hee,Kim, Jung Won,Choi, Baeck,Cho, Yong-Hun,Sung, Yung-Eun The Royal Society of Chemistry 2015 NEW JOURNAL OF CHEMISTRY Vol.39 No.8
<P>Core–shell structured Au–PtPd/C and Au–Pt/C nanoparticles (NPs) were prepared using a successive reduction process on carbon supported Au with PtPd and Pt particles. Structural analyses of the core–shell NPs revealed uniformly distributed fine particles (<5 nm in diameter) on carbon particles and selectively deposited Pt and bimetallic PtPd structures on the Au surface. The activity of the NPs was investigated for the oxygen reduction reaction (ORR) in both H<SUB>2</SUB>SO<SUB>4</SUB> solutions with and without CH<SUB>3</SUB>OH. In Au–Pt and Au–PtPd NPs, the activities for the ORR decreased in the solution without CH<SUB>3</SUB>OH as the amount of Pd increased; moreover, Au–PtPd NPs showed higher activity than Au–Pt NPs in solution with CH<SUB>3</SUB>OH due to its enhanced tolerance for methanol oxidation. Thus, the high methanol oxidation reaction tolerance of Au–PtPd NPs is ascribed to the synergistic effect resulting from its thin structure and bimetallic PtPd composition.</P> <P>Graphic Abstract</P><P>Core–shell structured Au–PtPd/C and Au–Pt/C nanoparticles (NPs) were prepared using a successive reduction process on carbon supported Au with PtPd and Pt particles. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c5nj00998g'> </P>
Park, Jin Ho,Lee, Sun Yong,Kim, Woe Yeon,Jung, Young Jun,Chae, Ho Byoung,Jung, Hyun Suk,Kang, Chang Ho,Shin, Mi Rim,Kim, Sun Young,Su’udi, Mukhamad,Yun, Dae Jin,Lee, Kyun Oh,Kim, Min Gab,Lee, Sang Yeo Blackwell Publishing Ltd 2011 The New phytologist Vol.191 No.3
<P><B>Summary</B></P><P><P>This study reports that <I>Arabidopsis thaliana</I> protein serine/threonine phosphatase 5 (AtPP5) plays a pivotal role in heat stress resistance. A high‐molecular‐weight (HMW) form of AtPP5 was isolated from heat‐treated <I>A. thaliana</I> suspension cells. AtPP5 performs multiple functions, acting as a protein phosphatase, foldase chaperone, and holdase chaperone. The enzymatic activities of this versatile protein are closely associated with its oligomeric status, ranging from low oligomeric protein species to HMW complexes.</P><P>The phosphatase and foldase chaperone functions of AtPP5 are associated primarily with the low‐molecular‐weight (LMW) form, whereas the HMW form exhibits holdase chaperone activity. Transgenic over‐expression of <I>AtPP5</I> conferred enhanced heat shock resistance to wild‐type <I>A. thaliana</I> and a T‐DNA insertion knock‐out mutant was defective in acquired thermotolerance. A recombinant phosphatase mutant (H290N) showed markedly increased holdase chaperone activity.</P><P>In addition, enhanced thermotolerance was observed in transgenic plants over‐expressing H290N, which suggests that the holdase chaperone activity of AtPP5 is primarily responsible for AtPP5‐mediated thermotolerance.</P><P>Collectively, the results from this study provide the first evidence that AtPP5 performs multiple enzymatic activities that are mediated by conformational changes induced by heat‐shock stress.</P></P>