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윤수원,진상윤,김예상,정순오 대한건축학회 2004 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.24 No.1
In high-rise building construction projects, curtain walls are one of the most widely used exterior finishing components as well as the key management factors in cost and schedule control. Generally it occupies about 10-15% of a total project cost. and its construction process is on the critical path, The life-cycle process of curtain walls involves a lot of actors such as owner, architect, contractor, curtain wall consultants, specialty contractors, and manufacturers, and information and material flow with being shared and exchanged among them. However fragmentation of actors results in inefficiency in control and management of the process. Therefore. the purpose of this paper is to analyze the whole curtain wall process construction to improve efficiency and productivity based on the supply chain management concept. waste. problems and their causes were analyzed based on the as-is model established by IDEFO modeling technique and finally recommendations were suggested for improvement.
윤수원,진상윤,김예상,정영수,정문헌,박순찬 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.2
Progress rate is one of the important factors that represent the performance and the status of a project through quantitative measurements of construction works performed. However, measuring progress rate has not been based on the collection of objective data and not based on the objective criteria either. Rather, since it has been dependent on one's subjective judgement or has included only the works measurable, it has been very difficult to assure the accuracy of a progress rate measurement in a construction project. Therefore the objective of this study is to propose a model that can improve the accuracy of a progress rate measurement by incorporating different measurement methods depending on the characteristics of unit work types. This research is still on-going at this point, however, this paper includes discussions on the development of the progress measurement method model along with analysis of literature survey and interviews with construction practitioners.
Single Nucleotide Primer Extension 기법을 이용한 SNP 연구
안영욱,예성수,박영홍 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.5
Single nucleotide polymorphisms(SNPs) are the most frequent type of DNA sequence variation of individuals. They are defined by the presence of two alternative bases at a particular position in a DNA sequence and occur about one per 500-1000bp in the human genome. The recent completion of the first reference sequence of the human genome has provided a basis for comprehensive analysis of sequence variation in man. The identification and dense mapping of SNPs is of considerable significance for association studies of complex diseases, pharmacogenetics, population genetics and physical mapping. Their use as genetic markers is favored by their high abundance, low mutation rate and the easy automation of typing. With the development of ABI Prism 3100 or 3700 system, single nucleotide primer extension, we car get a straightforward and large-scale method for validation of or comparative genotyping of known SNPs and point mutations. In the mini sequencing primer extension reaction, a DNA polymerase is used specifically to extend a primer that anneals immediately adjacent to the nucleotide position to be analyzed with a single labeled nucleoside triphosphate complementary to the nucleotide at the variant site. The reactor allows highly specific detection of point mutations and single nucleotide polymorphisms(SNPs) without direct sequencing. Because all SNPs can be analyzed with high specificity at the same reaction conditions, mini sequencing is a promising reaction principle for multiplex high-throughput genotyping assays. It is also a useful tool for accurate quantitative PCR-based analysis. This review discusses the advanced biotechnique.
장문석,윤수원,진상윤,김예상 대한건축학회 2004 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.24 No.1
Recently various sensing technologies have been adapted in construction works to support informatization. Among them, Radio Frequency Identification(RFID) is one of the most highlighted technologies, which has great potentials for construction applications. In this study, potentials for RFID application to the unite type curtain wall system of high-rise buildings have been investigated. To do this, current curtain wall construction process from design to installation was analyzed and modeled by IDEFO and scenarios of active and passive RFID application were suggested. This study will be continued to develop an automated life-cycle management system for curtain wall construction.
Genetic Variations and Haplotypes of UDP-glucuronosyltransferase 1A Locus in a Korean Population
Yea, Sung Su,Lee, Sang Seop,Kim, Woo-Young,Liu, Kwang-Hyeon,Kim, Hyojin,Shon, Ji-Hong,Cha, In-June,Shin, Jae-Gook Lippincott Williams Wilkins, Inc. 2008 Therapeutic drug monitoring Vol.30 No.1
Glucuronidation catalyzed by UDP-glucuronosyltransferases (UGTs) is one of the most important mechanisms for host defense against xenobiotics and endobiotics. Although genetic polymorphisms of several UGT1A isoforms have been reported separately, the haplotypes in all functional exons have not been identified, and little information is available regarding single nucleotide polymorphisms in Koreans. We analyzed genetic polymorphisms in all functional exons of the UGT1A locus by direct sequencing of genomic DNA from 50 healthy Korean subjects, and their haplotypes were inferred from genotype data using an expectation-maximization algorithm. We identified 67 polymorphisms, including three novel single nucleotide polymorphisms, 233C>T in UGT1A1 (T78M), 292C>T in 1A4 (Q98Stop), and 701T>C in 1A7 (I234T). Two amino acid substitutions, 1A4 Q98Stop and 1A7 I234T, were each associated with a decrease of enzymatic activity, whereas UGT1A1 T78M had no significant influence on catalytic function. The frequencies of the known variants in Koreans differed significantly from those reported in other ethnic groups. Haplotype analysis was performed within the polymorphisms in each UGT1A isoform as well as across the isoforms. Based on strong linkage disequilibrium within UGT1A7, between 1A5 and 1A4, and within 1A3, the complex was divided into three blocks, Block 7, Block 5/4, and Block 3. The haplotypes for each block were subsequently determined, revealing a profile that differed from those of other ethnic groups. These results suggest that genetic polymorphisms of the UGT1A locus differ between Koreans and other ethnic populations. Such differences should be considered in pharmacogenetic studies.