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C1q/TNF-α-Related Protein 1 (CTRP1) Maintains Blood Pressure Under Dehydration Conditions
Han, Sora,Jeong, Ae Lee,Lee, Sunyi,Park, Jeong Su,Buyanravjikh, Sumiyasuren,Kang, Wonku,Choi, Seungmok,Park, Changmin,Han, Jin,Son, Woo-Chan,Yoo, Kyung Hyun,Cheong, Jae Hoon,Oh, Goo Taeg,Lee, Won-Youn Ovid Technologies Wolters Kluwer -American Heart A 2018 Circulation research Vol.123 No.5
Boldbaatar, Ariundavaa,Lee, Sunyi,Han, Sora,Jeong, Ae Lee,Ka, Hye In,Buyanravjikh, Sumiyasuren,Lee, Jeong Hyung,Lim, Jong-Seok,Lee, Myung Sok,Yang, Young D.A. Spandidos 2017 Oncology letters Vol.14 No.5
<P>The epithelial-mesenchymal transition (EMT) is a hallmark of cancer metastasis, and the associated molecular signaling pathways are regarded as therapeutic targets for cancer treatment. Thus, suppressing EMT with a natural chemical compound may be of therapeutic benefit. Eupatolide is a natural chemical compound extracted from the medicinal plant <I>Inula britannica</I>, which is used in Eastern Asia to treat bronchitis, disorders of the digestive system and inflammation. Besides the anti-inflammatory function of eupatolide, the present study found that eupatolide suppressed the migration and invasion of breast cancer cells, which was associated with the downregulation of vimentin in MDA-MB-231 cells and the upregulation of E-cadherin in MCF-7 cells. Treatment with eupatolide also significantly inhibited the migration and invasion of breast cancer cells that had been stimulated with transforming growth factor-β1 (TGF-β1). Eupatolide also suppressed TGF-β1-induced EMT via downregulation of mothers against decapentaplegic homolog 3 (SMAD3) phosphorylation and transcriptional repression of TGF-β receptor 1 (ALK5). In addition to this canonical pathway, the non-canonical protein kinase B (AKT) and extracellular signal-regulated kinase (ERK) pathways were also inhibited by eupatolide treatment. In summary, the results suggest that eupatolide suppresses the migration and invasion of breast cancer cells by blocking the canonical ALK5-SMAD3 signaling pathway and the non-canonical ERK and AKT signaling pathways.</P>
Oncoprotein CIP 2A promotes the disassembly of primary cilia and inhibits glycolytic metabolism
Jeong, Ae Lee,Ka, Hye In,Han, Sora,Lee, Sunyi,Lee, Eun‐,Woo,Soh, Su Jung,Joo, Hyun Jeong,Sumiyasuren, Buyanravjkh,Park, Ji Young,Lim, Jong‐,Seok,Park, Jong Hoon,Lee, Myung Sok,Yang, Young EMBO 2018 EMBO reports Vol.19 No.5