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RISS 인기검색어
- 검색키워드
- 저자 : Suleyman Karakoyun (검색결과 2 건)
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Mean Platelet Volume and Vitamin D Level
Medine Cumhur Cure,Erkan Cure, M.D,Suleyman Yuce,TarkanYazici,Inanc Karakoyun,Hasan Efe 대한진단검사의학회 2014 Annals of Laboratory Medicine Vol.34 No.2
Background: Vitamin D deficiency and a high mean platelet volume (MPV) are related to cardiovascular disease. We investigated whether vitamin D deficiency is associated with high MPV. Methods: This study included 434 patients without chronic disease who were not taking vitamin D or calcium supplements. Vitamin D was measured by chemiluminescent mic- roparticle immunoassay on the Architect-I2000 system (Abbott Diagnostics, USA), and MPV was measured on the Cell-Dyn Ruby analyzer (Abbott Diagnostics). Patients were di- vided into Groups 1 (138 [men/women, 46/92]), 2 (148 [men/women, 54/94]), and 3 (148 [men/women, 50/98]) according to vitamin D levels of <10 ng/mL, 10-20 ng/mL, and >20 ng/mL, respectively. Results: The vitamin D level in Group 1 (7.7±1.9 ng/mL) was lower than that in Group 2 (15.1±1.6 ng/mL, P <0.001) and Group 3 (25.6±6.3 ng/mL, P <0.001). The MPV in Group 3 (7.5±1.0 fL) was lower than that in Group 1 (8.1±1.1 fL, P <0.001) and Group 2 (7.9±1.0 fL, P =0.009). Linear regression analysis showed that low levels of vitamin D (β=-0.109, P =0.019) was independently associated with increased MPV. Conclusions: There was a strong association between a low vitamin D level and a high MPV; therefore, vitamin D deficiency may be associated with increased MPV.
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Macit Kalcik,M. Ozan Gursoy,Suleyman Karakoyun,Mahmut Yesin,Mehmet Ali Astarcioglu,Mehmet Ozkan 대한심장학회 2014 Korean Circulation Journal Vol.44 No.4
An effective anticoagulation is critical in pregnant patients with prosthetic heart valves. Inherited disorders may interfere with the coagu-lation cascade and may be associated with obstetrical complications as well as with prosthetic valve-derived complications. The patient inthe present case had a history of recurrent prosthetic heart valve thrombosis (PHVT) despite an effective anticoagulation. She underwenta thrombolysis with low-dose prolonged infusion of tissue-type plasminogen activator for the management of her recurrrent prostheticvalve thrombosis. The genetic testing showed homozygous mutations of methylenetetrahydrofolate reductase (MTHFR) A 1298 C andheterozygous mutations of ß-fibrinogen 455 G-A. Inherited disorders such as MTHFR A 1298 C and fibrinogen 455G/A polymorphismsmay be involved in the pathogenesis of recurrent PHVT and/or pregnancy loss.
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