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Collapse Behavior of an 18-Story Steel Moment Frame during a Shaking Table Test
Suita, Keiichiro,Suzuki, Yoshitaka,Takahashi, Motomi Council on Tall Building and Urban Habitat Korea 2015 International journal of high-rise buildings Vol.4 No.3
A shaking table test was conducted at the E-Defense shaking table facility to investigate the damage and collapse behavior of a steel high-rise building under exceedingly large ground motions. The specimen is a one-third scale 18-story steel moment frame designed and constructed according to design specifications and practices used in the 1980s and 1990s. The shaking table tests used a long-duration, long-period ground motion simulated for a sequential Tokai, Nankai, and Nankai earthquake scenario. The building specimen was subjected to a series of progressively increasing scaled motions until it completely collapsed. The damage to the steel frame began through the yielding of beams along lower stories and column bases of the first story. After several excitations by increasing scaled motions, cracks initiated at the welded moment connections and fractures in the beam flanges spread to the lower stories. As the shear strength of each story decreased, the drifts of lower stories increased and the frame finally collapsed and settled on the supporting frame. From the test, a typical progression of collapse for a tall steel moment frame was obtained, and the hysteretic behavior of steel structural members including deterioration due to local buckling and fracture were observed. The results provide important information for further understanding and an accurate numerical simulation of collapse behavior.
Contribution of a Non-classical HLA Gene, HLA-DOA, to the Risk of Rheumatoid Arthritis
Okada, Y.,Suzuki, A.,Ikari, K.,Terao, C.,Kochi, Y.,Ohmura, K.,Higasa, K.,Akiyama, M.,Ashikawa, K.,Kanai, M.,Hirata, J.,Suita, N.,Teo, Y.Y.,Xu, H.,Bae, S.C.,Takahashi, A.,Momozawa, Y.,Matsuda, K.,Momoh University of Chicago Press [etc.] 2016 American journal of human genetics Vol.99 No.2
<P>Despite the progress in human leukocyte antigen (HLA) causal variant mapping, independent localization of major histocompatibility complex (MHC) risk from classical HLA genes is challenging. Here, we conducted a large-scale MHC fine-mapping analysis of rheumatoid arthritis (RA) in a Japanese population (6,244 RA cases and 23,731 controls) population by using HLA imputation, followed by a multi-ethnic validation study including east Asian and European populations (n=7,097 and 23,149, respectively). Our study identified an independent risk of a synonymous mutation at HLA-DOA, a non-classical HLA gene, on anti-citrullinated protein autoantibody (ACPA)-positive RA risk (p=1.4 x 10(-) 9), which demonstrated a cis-expression quantitative trait loci (cis-eQTL) effect on HLA-DOA expression. Trans-ethnic comparison revealed different linkage disequilibrium (LD) patterns in HLA-DOA and HLA-DRB1, explaining the observed HLA-DOA variant risk heterogeneity among ethnicities, which was most evident in the Japanese population. Although previous HLA fine-mapping studies have identified amino acid polymorphisms of the classical HLA genes as driving genetic susceptibility to disease, our study additionally identifies the dosage contribution of a non-classical HLA gene to disease etiology. Our study contributes to the understanding of HLA immunology in human diseases and suggests the value of incorporating additional ancestry in MHC fine-mapping.</P>