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Montmorillonite Clay Catalyzed Three Component, One-Pot Synthesis of 5-Hydroxyindole Derivatives
Reddy, B.V. Subba,Reddy, P. Sivaramakrishna,Reddy, Y. Jayasudhan,Bhaskar, N.,Reddy, B. Chandra Obula Korean Chemical Society 2013 Bulletin of the Korean Chemical Society Vol.34 No.10
A highly efficient and environmentally benign protocol has been developed for the first time to produce a wide range of biologically active 5-hydroxyindole derivatives using montmorillonite KSF clay as a reusable solid acid catalyst. The use of recyclable clay makes this procedure quite simple, more convenient and cost-effective.
Reddy, P. Rama Subba,Eswaramma, S.,Krishna Rao, K.S.V.,Lee, Yong Ill Korean Chemical Society 2014 Bulletin of the Korean Chemical Society Vol.35 No.8
Novel dual responsive pectin hydrogels composed from poly(acrylamidoglycolic acid-co-vinylcaprolactam)/Pectin (PAV-PC) and also PAV-PC hydrogels are used as templates for the production of silver nanoparticles. 5-Fluorouracil is an anticancer drug and has been loaded in situ into PAV-PC hydrogels. Structure and morphology characterization of PAV-PC hydrogels were investigated by fourier transform infrared spectroscopy, differential scanning calorimetry, thermo gravimetric analysis, X-ray diffraction studies, scanning electron microscopy and transmission electron microscopy. The results revealed a molecular level dispersion of the drug in PAV-PC hydrogels. In vitro release of 5-fluorouracil from the PAV-PC hydrogels has been carried out in GIT fluids as well as in various temperatures. 5-Fluorouracil released from PAV-PC hydrogels was 50% at pH 1.2, and 85% at pH 7.4 within 24 h. The release profile was characterized with PAV-PC hydrogels and initial burst effect was significantly reduced in two buffer media (1.2 and 7.4), followed by a continuous and controlled release phase, the drug release mechanism from polymer was due to Fickian diffusion. In situ fabrication of silver nanoparticles inside the hydrogel network via the reduction of sodium borohydrate by PAV-PC chains led to hydrogel nanocomposites. The diameter of the nanocomposites was about 50-100 nm, suitable for uptake within the gastrointestinal tract due to their nanosize range and mucoadhesive properties. These nanocomposite PAV-PC hydrogels showed strong antimicrobial activity towards Bacillus subtilis (G+ve) and Escherichia coli (G-ve).
Synthesis and evaluation of the cytotoxic activities of some isatin derivatives.
Reddy, Sanapalli Subba,Pallela, Ramjee,Kim, Dong-Min,Won, Mi-Sook,Shim, Yoon-Bo Pharmaceutical Society of Japan 2013 Chemical & pharmaceutical bulletin Vol.61 No.11
<P>A series of isatin derivatives, 1-butyl-5/7-chloro/fluoro-3-((4-methoxybenzyl)imino)indolin-2-ones (3a-d), 6-butyl-chloro/fluoro-6H-indolo[2,3-b]quinoxalines (4a-h), and 5/7-chloro/fluoro-3-((4-methoxybenzyl)imino)indolin-2-ones (5a-h) were synthesized and characterized by using Fourier transform (FT)-IR, (1)H- and (13)C-NMR spectroscopy, mass spectrometric and elemental analysis. The substances were further subjected to in vitro cytotoxicity evaluation against HeLa, SK-BR-3, and MCF-7 cells. The results showed that quinoxalines 4d, 4e, and 4g; and indolin-2-one 5f display significant in vitro cytotoxic activities against HeLa cells and further the compound 4d has resulted in highest cytotoxicity in the entire series studied. In addition, 5f was shown to display substantial activity against all the three cell lines used in the current study.</P>
Mesoporous silica (MCM-41) effect on (PEO+LiAsF<sub>6</sub>) solid polymer electrolyte
Subba Reddy, Ch.V.,Wu, G.P.,Zhao, C.X.,Jin, W.,Zhu, Q.Y.,Chen, W.,Mho, Sun-il Elsevier 2007 CURRENT APPLIED PHYSICS Vol.7 No.6
<P><B>Abstract</B></P><P>Composite polymer electrolyte films consisting of polyethylene oxide (PEO), LiAsF<SUB>6</SUB> and mesoporous silica (MCM-41) with fixed PEO/LiAsF<SUB>6</SUB>=90/10 but different weight percent ratios of MCM-41 were prepared using the solution casting method. The polymer electrolyte films were characterized using XRD, DSC, SEM and electrical impedance spectroscopy. In corporation of MCM-41 in a (PEO+LiAsF<SUB>6</SUB>) polymer electrolyte facilitates salt dissociation, enhances ion conductivity, and improves miscibility between organic and inorganic moieties. The scanning electron microscopy (SEM) photographs indicates the electrolytes are miscible and homogeneous up to 10wt.% of MCM-41, and an optimized conductivity is found at this composition (10wt.%). However, at higher weight ratios (>10wt.%), the Li/MCM-41-rich domain developed, and the conductivity decreased with increasing mesoporous material. The electrochemical performance of fabricated electrochemical cells of configuration Li/(PEO+LiAsF<SUB>6</SUB>+MCM-41)/(MoO<SUB>3</SUB>+C+PTFE) were investigated.</P>
( Subba Reddy ),( Yong Hyun Baek ),( Seong Gyeong Kim ),( Hur Bo Young ) 한국주조공학회 2014 한국주조공학회지 Vol.34 No.3
Permeability is the ability of a material to transmit fluid/gases. It is an important material property and it depends on mould parameters such as grain fineness number, clay, moisture, mulling time, and hardness. Modeling the relationships among these variable and interactions by mathematical models is complex. Hence a biologically inspired artificial neural network technique with a back-propagation-learning algorithm was developed to estimate the permeability of green sand. The developed model was used to perform a sensitivity analysis to estimate permeability. The individual as well as the combined influence of mould parameters on permeability were simulated. The model was able to describe the complex relationships in the system. The optimum process window for maximum permeability was obtained as 8.75-10.5% clay and 3.9-9.5% moisture. The developed model is very useful in understanding various interactions between inputs and their effects on permeability.
Reddy, Lakshmi C. Narayana,Reddy, Rama Subba P.,Rao, Krishna K.S.V.,Subha, M.C.S.,Rao, Chowdoji K. Korean Chemical Society 2013 대한화학회지 Vol.57 No.4
Chitosan (CS) and hydroxypropylmethyl cellulose (HPMC) blend microspheres were prepared by water-in-oil emulsion technique and were loaded with an anti-cancer drug 5-fluorouracil (5-FU). CS-HPMC microspheres were characterized by Fourier transform infrared spectroscopy to confirm the cross-linking reaction. Scanning electron microscopy (SEM) was also used to assess the surface morphology of particles prepared. The quantity of release of 5-FU from the microspheres have been studied in terms of blend composition and amount of cross-linking agent. Differential scanning calorimetry and X-ray diffraction techniques indicated a uniform distribution of 5-FU particles in microspheres, whereas SEM suggested the spherical structure of the microspheres with slight rough surface. The in vitro drug release indicated that the particle size and release kinetics depend upon blend composition, amount of cross-linking agent used and amount of 5-FU present in the microspheres.
Venkata Subba Reddy Gangireddygari,조인숙,최세나,윤주연 인간식물환경학회 2023 인간식물환경학회지 Vol.26 No.1
Background and objective: Plant viruses are major obstacles to enhancing crop productivity in both agriculture and horticulture throughout the world, resulting in losses of several billion dollars every year. Controlling viruses is arduous, so agrochemicals are widespread. To minimize the usage of those, this study's objective was to assess bacterial cultures supernatants on pepper mild mottle virus (PMMoV) in chili pepper plants and identify its secondary metabolites. Methods: This 48-h grown Pseudomonas putida (PP) and Bacillus licheniformis (BL) cultures supernatants were foliar sprayed separately in chili pepper plants 24-h before PMMoV inoculation (T1), and 24-h before and after PMMoV inoculation (T2), 2wpi (week's post inoculation), the virus titer was determined by using a double antibody sandwich enzyme-linked immunosorbent assay (DAS-ELISA), and the supernatants were extracted with ethyl acetate and concentrated by rota-evaporation before being analyzed in gas chromatography mass spectrometry (GC-MS). Results: The culture supernatants of PP and BL inhibit PMMoV by 43-47% in both the treatments (T1 & T2) compared to the control. The GC-MS chromatogram of two cultures of supernatants identified the molecules of cyclo (Pro-Val), cyclo (Pro-Leu), and cyclo (Phe-Pro). Commercial forms of these three molecules at three concentrations showed a hypersensitive response, ranging from 45-65% for PMMoV in Nicotiana glutinosa. Conclusion: The results revealed that supernatants of PP and BL-containing compounds have biological control of PMMoV in chili pepper plants.