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- 저자 : Stefanie Hölscher-Doht (검색결과 1 건)
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Oliver Berberich,Julia Blöhbaum,Stefanie Hölscher-Doht,Rainer H. Meffert,Jörg Teßmar,Torsten Blunk,Jürgen Groll 한국공업화학회 2019 Journal of Industrial and Engineering Chemistry Vol.80 No.-
Tissue adhesives play an important role in clinical applications and may aid in the treatment of cartilagedefects for improved cartilage integration. However, many fail to satisfy the demand for adequateadhesive strength on wet tissue surfaces and to facilitate sufficient cell migration and extracellular matrix(ECM) deposition at the defect site. Utilizing poly(2-alkyl-2-oxazoline) (POx)-based polymers equippedwith mussel-inspired adhesion moieties and combining them with the natural wound sealantfibrinogen,we fabricated an adhesive biosynthethic hydrogel with tunable mechanical properties and improvedbonding strength. Degradation of the hydrogels could be adjusted by the ratio of amide to ester linkagesof the catecholic functional group at the POx side chain. In an in vitro disc/ring model for lateral cartilageintegration, a benefit in long-term integration was observed with enhanced degradation of the adhesivewithout the expense of bonding strength. Incorporation of degradable ester linkages in the polymerfacilitated cell invasion and strong deposition of cartilaginous ECM at the defect site. Overall, the resultssuggest that the presented injectable adhesive hydrogel, due to its easy tunability, holds great potentialfor cartilage defect treatment and other medical applications.
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