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CellFinder: a cell data repository
Stachelscheid, Harald,Seltmann, Stefanie,Lekschas, Fritz,Fontaine, Jean-Fred,Mah, Nancy,Neves, Mariana,Andrade-Navarro, Miguel A.,Leser, Ulf,Kurtz, Andreas Oxford University Press 2014 Nucleic acids research Vol.42 No.d1
<P>CellFinder (http://www.cellfinder.org) is a comprehensive one-stop resource for molecular data characterizing mammalian cells in different tissues and in different development stages. It is built from carefully selected data sets stemming from other curated databases and the biomedical literature. To date, CellFinder describes 3394 cell types and 50 951 cell lines. The database currently contains 3055 microscopic and anatomical images, 205 whole-genome expression profiles of 194 cell/tissue types from RNA-seq and microarrays and 553 905 protein expressions for 535 cells/tissues. Text mining of a corpus of >2000 publications followed by manual curation confirmed expression information on ∼900 proteins and genes. CellFinder’s data model is capable to seamlessly represent entities from single cells to the organ level, to incorporate mappings between homologous entities in different species and to describe processes of cell development and differentiation. Its ontological backbone currently consists of 204 741 ontology terms incorporated from 10 different ontologies unified under the novel CELDA ontology. CellFinder’s web portal allows searching, browsing and comparing the stored data, interactive construction of developmental trees and navigating the partonomic hierarchy of cells and tissues through a unique body browser designed for life scientists and clinicians.</P>
Rossbach, B.,Hildebrand, L.,El-Ahmad, L.,Stachelscheid, H.,Reinke, P.,Kurtz, A. Elsevier 2016 Stem cell research Vol.16 No.2
<P>We have generated a human induced pluripotent stem cell (iPSC) line derived from urinary cells of a 30 year old healthy female donor. The cells were reprogrammed using a non-integrating viral vector and have shown full differentiation potential. Together with the iPSC-line, the donor provided blood cells for the study of immunological effects of the iPSC line and its derivatives in autologous and allogeneic settings. The line is available and registered in the human pluripotent stem cell registry as BCRTi004-A. (C) 2016 The Authors. Published by Elsevier B.V.</P>
Rossbach, B.,Hildebrand, L.,El-Ahmad, L.,Stachelscheid, H.,Reinke, P.,Kurtz, A. Elsevier 2017 Stem cell research Vol.21 No.-
<P>We have generated a human induced pluripotent stem cell (iPSC) line derived from urinary cells of a 28 year old healthy female donor. The cells were reprogrammed using a non-integrating viral vector and have shown full differentiation potential. Together with the iPSC line, the donor provided blood cells for the study of immunological effects of the iPSC line and its derivatives in autologous and allogeneic settings. The line is available and registered in the human pluripotent stem cell registry as BCRTi005-A. (C) 2016 The Authors. Published by Elsevier B.V.</P>
hPSCreg—the human pluripotent stem cell registry
Seltmann, Stefanie,Lekschas, Fritz,Mü,ller, Robert,Stachelscheid, Harald,Bittner, Marie-Sophie,Zhang, Weiping,Kidane, Luam,Seriola, Anna,Veiga, Anna,Stacey, Glyn,Kurtz, Andreas Oxford University Press 2016 Nucleic acids research Vol.44 No.d1
<P>The human pluripotent stem cell registry (hPSCreg), accessible at http://hpscreg.eu, is a public registry and data portal for human embryonic and induced pluripotent stem cell lines (hESC and hiPSC). Since their first isolation the number of hESC lines has steadily increased to over 3000 and new iPSC lines are generated in a rapidly growing number of laboratories as a result of their potentially broad applicability in biomedicine and drug testing. Many of these lines are deposited in stem cell banks, which are globally established to store tens of thousands of lines from healthy and diseased donors. The Registry provides comprehensive and standardized biological and legal information as well as tools to search and compare information from multiple hPSC sources and hence addresses a translational research need. To facilitate unambiguous identification over different resources, hPSCreg automatically creates a unique standardized name for each cell line registered. In addition to biological information, hPSCreg stores extensive data about ethical standards regarding cell sourcing and conditions for application and privacy protection. hPSCreg is the first global registry that holds both, manually validated scientific and ethical information on hPSC lines, and provides access by means of a user-friendly, mobile-ready web application.</P>