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- 저자 : Spielman, Daniel Mark (검색결과 2 건)
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Gradient moment compensated magnetic resonance spectroscopic imaging
Kim, Dong-Hyun,Gu, Meng,Spielman, Daniel M. Wiley Subscription Services, Inc., A Wiley Company 2009 Magnetic resonance in medicine Vol.61 No.2
<P>Spectroscopic imaging applications outside of the brain can suffer from artifacts due to inherent long scan times and susceptibility to motion. A fast spectroscopic imaging sequence has been devised with reduced sensitivity to motion. The sequence uses oscillating readout gradients and acquires k-space data in a spiral out–in fashion, which allows fast k-space coverage. We show that a spiral out–in readout acquisition is characterized by small gradient moments, reducing sensitivity to motion-induced artifacts. Data are acquired comparing the sequence to normal phase encoded spectroscopic imaging and conventional spiral spectroscopic imaging protocols. In addition, in vivo data are acquired from the liver, demonstrating potential usage as a multivoxel fat/water spectroscopic imaging tool. Results indicate that in the presence of motion, ghosting effects are reduced while metabolite signal increases of approximately 10% can be achieved. Magn Reson Med 61:457–461, 2009. © 2009 Wiley-Liss, Inc.</P>
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Fast 3D <sup>1</sup>H MRSI of the corticospinal tract in pediatric brain
Kim, Dong-Hyun,Gu, Meng,Cunningham, Charles,Chen, Albert,Baumer, Fiona,Glenn, Orit A.,Vigneron, Daniel B.,Spielman, Daniel Mark,Barkovich, Anthony James Wiley Subscription Services, Inc., A Wiley Company 2009 Journal of Magnetic Resonance Imaging Vol.29 No.1
<B>Purpose</B><P>To develop a <SUP>1</SUP>H magnetic resonance spectroscopic imaging (MRSI) sequence that can be used to image infants/children at 3T and by combining it with diffusion tensor imaging (DTI) tractography, extract relevant metabolic information corresponding to the corticospinal tract (CST).</P><B>Materials and Methods</B><P>A fast 3D MRSI sequence was developed for pediatric neuroimaging at 3T using spiral k-space readout and dual band RF pulses (32 × 32 × 8 cm field of view [FOV], 1 cc iso-resolution, TR/TE = 1500/130, 6:24 minute scan). Using DTI tractography to identify the motor tracts, spectra were extracted from the CSTs and quantified. Initial data from infants/children with suspected motor delay (n = 5) and age-matched controls (n = 3) were collected and N-acetylaspartate (NAA) ratios were quantified.</P><B>Results</B><P>The average signal-to-noise ratio of the NAA peak from the studies was ≈22. Metabolite profiles were successfully acquired from the CST by using DTI tractography. Decreased NAA ratios in those with motor delay compared to controls of ≈10% at the CST were observed.</P><B>Conclusion</B><P>A fast and robust 3D MRSI technique targeted for pediatric neuroimaging has been developed. By combining with DTI tractography, metabolic information from the CSTs can be retrieved and estimated. By combining DTI and 3D MRSI, spectral information from various tracts can be obtained and processed. J. Magn. Reson. Imaging 2009;29:1–6. © 2008 Wiley-Liss, Inc.</P>
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