Polydiacetylenes Bearing Boronic Acid Groups as Colorimetric and Fluorescence Sensors for Cationic Surfactants

Lee, Songyi,Lee, Kyung Mi,Lee, Minji,Yoon, Juyoung American Chemical Society 2013 ACS APPLIED MATERIALS & INTERFACES Vol.5 No.11

<P>A new polydiacetylene oxyphenylboronic acid (<B>PDA-OPBA-1</B>) bearing group was synthesized and showed diverse colorimetric changes, such as yellow, orange, and red, upon the addition of cationic surfactants at pH 7.4. On the other hand, anionic surfactants and simple ammonium salts did not show any color change. Specifically, color changes to yellow for cetyl trimethylammonium chloride (CTAC), red for dodecyl trimethylammonium bromide (DTAB), orange for benzylcetyldimethylammonium chloride (BCDA), and dark orange for hexadecylpyridium bromide (HDPB) are observed, respectively. Different head groups and alkyl chain lengths of cationic surfactants can be intelligently distinguished via a unique penetration process.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/aamick/2013/aamick.2013.5.issue-11/am3030245/production/images/medium/am-2012-030245_0010.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/am3030245'>ACS Electronic Supporting Info</A></P>

F-31 The prognosis of lung cancer in patient with idiopathic pulmonary fibrosis according to treatment modality

( Songyi Han ),( Youlim Kim ),( Yeonjoo Lee ),( Jong Sung Park ),( Young-jae Cho ),( Ho Il Yoon ),( Jae Ho Lee ),( Choon-taek Lee ),( Sang Hoon Lee ) 대한결핵 및 호흡기학회 2017 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.124 No.-

Background: There were evidences that IPF is one of the important risk factor of lung cancer (LC) and as time passes after the diagnosis of IPF. In this study, we aim to find out what treatments are associated with a better prognosis for LC patients with IPF. Method: From 2003 to 2016, a total of 299 patients with both IPF and LC were searched by the diagnostic name in the Seoul National University Bundang hospital. 168 patients were included in the analysis except for other form of ILD, infection (n=13), other malignancy (n=11), and missing data (n=102). Among the patients, 21 were conservative therapy, 66 were surgery, 69 were chemotherapy, and 6 were treated for radiation therapy as primary treatment. GAP score was calculated with gender, age, FVC, and DLCO as Ley et al. reported. Results: The average age was 69.9 years and the men were dominant (92.9%). The overall survival rate was high in surgery (p<0.001; HR, 0.144) and chemotherapy (p=0.046; HR, 0.487). Surgery (p=0.014; HR, 0.244) increased the survival rate in the lung cancer stage I, II, and IIIa, and chemotherapy (p<0.001; HR, 0.168) and surgery (p=0.003; HR, 0.033) improved the survival rate in the IIIb and IV, compared to the conservative care. The survival rate was improved by surgery (p<0.001; HR, 0.132) in GAP stage I and was increased by chemotherapy (p = 0.007; HR, 0.145) in stages II and III. Conclusion: Although the motality of IPF-associated LC is higher than lung cancer only, it seems to be effective for surgery or chemotherapy depending on the lung cancer or IPF stage.

Unprecedented colorimetric responses of polydiacetylenes driven by plasma induced polymerization and their patterning applications

Lee, Songyi,Cho, Yukyung,Ye, Byeong Uk,Baik, Jeong Min,Kim, Myung Hwa,Yoon, Juyoung The Royal Society of Chemistry 2014 Chemical communications Vol.50 No.83

<P>We report for the first time that polydiacetylenes (PDAs) can be alternatively prepared <I>via</I> a plasma induced polymerization process. The degree of polymerization and colorimetric transitions could be manipulated by controlling the power of plasma radiofrequency, exposure time and by using an acrylic mask, resulting in their great potential for patterning applications.</P> <P>Graphic Abstract</P><P>In this communication, we report that polydiacetylenes (PDAs) can be alternatively prepared <I>via</I> a plasma induced polymerization process. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c4cc03511a'> </P>

Production of immunodeficient mouse models to study human diseases

SongYi Park,Jaehoon Lee,Na-Yeong Ha,Hae Deun Kim,Yang-Kyu Choi,Han-Woong Lee 한국실험동물학회 2018 한국실험동물학회 학술발표대회 논문집 Vol.2018 No.1

Fluorescent and colorimetric chemosensors for pyrophosphate

Lee, Songyi,Yuen, Karen K. Y.,Jolliffe, Katrina A.,Yoon, Juyoung The Royal Society of Chemistry 2015 Chemical Society reviews Vol.44 No.7

<P>Pyrophosphate anions play key roles in various biological and chemical processes. During the last few years, many exciting results have emerged regarding the development of fluorescent and colorimetric sensors for this biologically important species. In this review, we will cover the fluorescent and colorimetric chemosensors developed for the detection of pyrophosphate (PPi) since 2010.</P> <P>Graphic Abstract</P><P>In this review, we will cover the fluorescent and colorimetric chemosensors developed for the detection of pyrophosphate (PPi) since 2010. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c4cs00353e'> </P>

Recent progress on the development of glutathione (GSH) selective fluorescent and colorimetric probes

Lee, Songyi,Li, Jun,Zhou, Xin,Yin, Jun,Yoon, Juyoung Elsevier 2018 Coordination Chemistry Reviews Vol.366 No.-

<P><B>Abstract</B></P> <P>Glutathione (GSH) plays a key role in many cellular functions. Abnormal levels of GSH is considered to be sign of many diseases. As a result, various fluorescent imaging probes and/or chemosensors for GSH have been developed. Compared to other analytical methods, fluorescence has unique merits, such as excellent detection limits and sensitivity for use in imaging cells, tissues and small animals. However, colorimetric probes undergo distinct color changes, which in most cases can be detected by using the naked eye. This review of studies aimed at the development of GSH probes is presented in a format that is organized by structural features and chemical reactions of the probes. The topics include probes that are based on nanoparticles or nanocomposites, metal ion displacement and coordination and chemical reactions. The reaction based probes are further classified into probes that undergo cleavage of sulphonamide, sulfonate ester and related functional groups, SeN bond cleavage, aryl substitution reactions, disulfide bond cleavage followed by cyclization, Michael additions, and other processes.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Fluorescent and colorimetric probes for GSH based on nanoparticles and small organic molecules are reviewed. </LI> <LI> Sensing mechanisms of GSH selective fluorescent and colorimetric probes are discussed. </LI> <LI> Probes for bioimaging GSH and applications to disease diagnosis. </LI> </UL> </P>

Healing experiences of middle-aged women through an urban forest therapy program

Lee, Hyun Jin,Son, Yong-Hoon,Kim, Songyi,Lee, Dong Kun ELSEVIER SCIENCE B.V. AMSTERDAM 2019 URBAN FORESTRY AND URBAN GREENING Vol.38 No.-

<P><B>Abstract</B></P> <P>The aim of this study was to explore and describe the processes of therapeutic effects of the urban forest on middle-aged women by examining their involvement in an urban forest therapy program. The qualitative data used in this study were collected from focus group discussions using semi-structured interviews and analyzed using grounded theory. A core category and four subcategories were created to describe the participants’ psychological changes as a result of the therapy program. “Efforts to recognize self-worth” was chosen as the core category. At first, the participants were unfamiliar with their surroundings when they entered the urban forest with strangers. Gradually, participants’ attitudes toward their external environment shifted to feelings of comfort and calm owing to an increased awareness of the value of the urban forest. After they acquired knowledge of the forest and experienced emotional bonding with each other, their mental attitudes changed; this allowed them to identify with nature and start reflecting about their own lives. They were then able to develop coping abilities that led to self-healing. The findings of the study illustrated the participants’ self-healing processes through interactions with nature, guides, and other group members.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Urban forest therapy promotes positive mental change. </LI> <LI> Easy accessibility of urban forests encourages their use. </LI> <LI> Urban forests facilitate self-healing by providing a self-immersed environment. </LI> </UL> </P>

Impact of Irradiation on laryngeal hydration and lubrication in rat larynx.

Lee, Songyi,Choi, Jeong-Seok,Kim, Hun Jung,Kim, Young-Mo,Lim, Jae-Yol Triological Foundation [etc.] 2015 The Laryngoscope Vol.125 No.8

<P>The larynx is susceptible to irradiation, which causes significant vocal fold (VF) edema and dehydration shortly after radiotherapy for head and neck cancers. However little is known about radiation-induced damage to VF liquid homeostasis. To evaluate the effects of irradiation on VF hydration and lubrication, we investigated changes in water transporters (aquaporins [AQPs]) and mucin production in vivo and ex vivo, as well as morphometric changes in the laryngeal mucosa and glands of irradiated rat larynges.</P>

A study on the relationship between emotions and brain signals evoked by head-up display images

Songyi Chae,Gyouhyung Kyung,Sungryul Park,Kyunghyun Nam,Kyungro Lee,Young Hee Lee 대한인간공학회 2012 대한인간공학회 학술대회논문집 Vol.2012 No.5

Objective: This study investigated the relationship between emotions and brain signals evoked by vehicle head-up display (HUD) images. Background: Prior studies showed that HUD images can evoke different emotions such as happy, sad, angry, disgusted, scared and neutral feelings. EEG signals have been used for a non-touch based user interface. Method: 20 Participants were exposed to 18 HUD images in the laboratory-based and driving simulator-based settings. The HUD images were different each other in terms of their content, amount of information, location, font, and color. 16-channel EEG signals were obtained during each HUD image exposure, and were later used to calculate 3 EEG indices such as EEG activity, concentration level and relaxation level. In addition, the participants reported their emotion they felt from each HUD image on semantic differential scales with two bipolar adjectives (range: 1-7). Results: The HUD images showed different effects on emotion, concentration, and EEG activity. Conclusion: Color appeared to be a key factor for determining the type of emotion evoked, whereas the amount of information appeared to determine the brain activation level in the central lobe. Especially, neural activities in the temporal lobe showed a positive association with concentration level. Application: Findings on association between emotions and EEG signals can be used for designing a new type of DVI (driver-vehicle interface).

Selective homocysteine turn-on fluorescent probes and their bioimaging applications

Lee, Hye Yeon,Choi, Yoon Pyo,Kim, Sunkyung,Yoon, Taejin,Guo, Zhiqian,Lee, Songyi,Swamy, K. M. K.,Kim, Gyoungmi,Lee, Jin Yong,Shin, Injae,Yoon, Juyoung unknown 2014 Chemical Communications Vol. No.

<P>The design and development of new pyrene-based fluorescent probes, <B>P-Hcy-1</B> and <B>P-Hcy-2</B>, which display selective fluorescence enhancements in response to homocysteine (Hcy), are described. The distinctly different fluorescence responses of <B>P-Hcy-1</B> and <B>P-Hcy-2</B> to Hcy <I>vs.</I> Cys are explained by theoretical calculations. Finally, the results of cell experiments show that these probes can be used to selectively detect Hcy in mammalian cells.</P> <P>Graphic Abstract</P><P>The design and development of new pyrene-based fluorescent probes, <B>P-Hcy-1</B> and <B>P-Hcy-2</B>, which display selective fluorescence enhancements in response to homocysteine (Hcy), are described. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c4cc00243a'> </P>