Thematic Pavilion

soma 현대건축사 2012 월간 CONCEPT Vol.- No.158

INNOVATION UNDER THE THREAT OF DIRECT FOREIGN INVESTMENT

SOMA ROY;RAJAT ACHARYYA 경제연구소 2009 Journal of Economic Development Vol.34 No.1

We examine the implication of direct and indirect foreign competition on domestic innovation decision. In most of the existing theoretical analyses the foreign firms are assumed to enter the domestic-country market as an exporter and thus are subject to a tariff duty imposed by the local government. We consider a broader setting where the foreign firm also has the option of setting up a production unit in the domestic country to supply output to the domestic country. This enables it to avoid the tariff that it faces due to export. Once we allow for such a strategy option for the foreign firm, competition becomes more direct and intense since tariffs no longer discount for the technological inferiority of home firms. We show that innovation by the home firm will be discouraged at high tariffs under the threat of DFI. Again at low tariff rates exports by the foreign firm make market competition more intense and reduce the incentive for innovation. Hence the home firm always (never) innovates at low (high) R&D cost whatever be the tariff rate. For intermediate R&D cost the home firm innovates if the foreign firm opts for exports.

INNOVATION UNDER THE THREAT OF DIRECT FOREIGN INVESTMENT

SOMA ROY,RAJAT ACHARYYA 중앙대학교 경제연구소 2009 Journal of Economic Development Vol.34 No.1

We examine the implication of direct and indirect foreign competition on domestic innovation decision. In most of the existing theoretical analyses the foreign firms are assumed to enter the domestic-country market as an exporter and thus are subject to a tariff duty imposed by the local government. We consider a broader setting where the foreign firm also has the option of setting up a production unit in the domestic country to supply output to the domestic country. This enables it to avoid the tariff that it faces due to export. Once we allow for such a strategy option for the foreign firm, competition becomes more direct and intense since tariffs no longer discount for the technological inferiority of home firms. We show that innovation by the home firm will be discouraged at high tariffs under the threat of DFI. Again at low tariff rates exports by the foreign firm make market competition more intense and reduce the incentive for innovation. Hence the home firm always (never) innovates at low (high) R&D cost whatever be the tariff rate. For intermediate R&D cost the home firm innovates if the foreign firm opts for exports.

Interaction between Peptidyl-prolyl Cis-trans Isomerase NIMA-interacting 1 and GTP-H-Ras: Implications for Aggressiveness of Human Mammary Epithelial Cells and Drug Resistance

Soma Saeid,주시형,김수정,Achanta Sri Venkata Jagadeesh,서영준 대한암예방학회 2020 Journal of cancer prevention Vol.25 No.4

Aberrant activation of Ras has been implicated in aggressiveness of breast cancer. Among Ras isoforms (H-, K-, and N-), H-Ras has been known to be primarily responsible for invasion and metastasis of breast cancer cells. Phosphorylation of serine (Ser) or threonine (Thr) is a key regulatory mechanism responsible for controlling activities and functions of various proteins involved in intracellular signal transduction. Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, Pin1 changes the conformation of a subset of proteins phosphorylated on Ser/Thr that precedes proline (Pro). In this study we have found that Pin1 is highly overexpressed in human breast tumor tissues and H-Ras transformed human mammary epithelial (H-Ras MCF10A) and MDA-MB-231 breast cancer cells. Notably, Pin1 directly bound to the activated form of H-Ras harbouring a Ser/Thr-Pro motif. Pharmacologic inhibition of Pin1 reduced clonogenicity of MDA-MB-231 human breast cancer cells. Paclitaxel accelerates apoptosis in Pin1 silenced H-Ras MCF10A cells. MDR genes (MDR1 and MRP4) were significantly downregulated in MDA-MB-231 cells stably silenced for Pin1. We speculate that Pin1 interacts with GTP-H-Ras, thereby upregulating the expression of drug resistance genes, which confers survival advantage and aggressiveness of breast cancer cells under chemotherapy. Key Words Breast neoplasm, Drug resistance, H-Ras, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

OBSERVATIONS OF THE ANNULAR ECLIPSE ON 2012 MAY 21 BY THE GENERAL PUBLIC IN JAPAN

SOMA, MITSURU The Korean Astronomical Society 2015 天文學論叢 Vol.30 No.2

We had a campaign of observing the annular solar eclipse on 2012 May 21 by naked eye through eclipse eyeglasses to determine the limit line of annularity. As a result, we had about 15,000 reports through our website. In addition there were many observation groups for which about 30,000 people in total participated in the observations. The overall result was that the limit we observed by naked eye through eclipse glasses coincided with a prediction that took into account the lunar limb irregularity within the error of ${\pm}500m$. This error of the limit line location corresponds to about ${\pm}200km$ of the radius of the Sun.

Effect of Filler Particle Alloy of Magnetic Composite Resin and Magnet Type on Magnetic Attractive Force

Soma H,Miyagawa Y 대한치과재료학회 2011 대한치과기재학회 학술대회 Vol.2011 No.5

Epidemiology of Oral Lichen Planus in a Cohort of South Indian Population: A Retrospective Study

Soma Susan Varghese,Giju Baby George,Sreenivasan Bargavan Sarojini1,Sankar Vinod,Philips Mathew,Deepu George Mathew,Joseph Sebastian,Arun George 대한암예방학회 2016 Journal of cancer prevention Vol.21 No.1

Background: Oral lichen planus (OLP) is an immune-mediated potentially malignant disorder of the oral cavity. Dysplastic OLP has an altered cytogenic profile and can progress into oral squamous cell carcinoma. The epidemiology of OLP is well-described in several relatively large series from various geographic locations, whereas such series from southern India is rare. The aim of the present study was to determine the epidemiology of OLP in a cohort of South Indian population. Methods: All the case data records of 29,606 patients who visited Mar Baselios Dental College and Hospital, Kerala, India from 2014 to 2015 were retrospectively reviewed. For data review, 122 patients of OLP were selected Estimated were type, number, and location of lesions, clinical manifestation, age of the patient, gender, onset and duration of lesion, stressful life style, habits, skin involvement and associated systemic illness, and presence/absence of dysplasia. Results: When the distribution of OLP among the gender was considered, we found more prevalence in females than males. Fifty-seven percent of patients were associated with stressful lifestyle. Reticular lichen planus was the most common clinical subtype found. Bilateral buccal mucosal was the common site, when the distribution of sites of OLP were compared (P < 0.05). Hypersensitivity reaction was frequently associated with systemic illness with OLP (P < 0.05). Anaplasia was found among 5% of lichen planus lesions. Conclusions: OLP patients had high incidence of hypersensitivity reactions and 5% of OLP lesions showed anaplasia. Long term follow-up is necessary to monitor the recurrence, prognosis, and malignant transformation of OLP.

Evaluation and Comparison of the Biopathology of Collagen and Inflammation in the Extracellular Matrix of Oral Epithelial Dysplasias and Inflammatory Fibrous Hyperplasia Using Picrosirius Red Stain and Polarising Microscopy: A Preliminary Study

Soma Susan Varghese,Sreenivasan Bargavan Sarojini1,Giju Baby George,Sankar Vinod,Philips Mathew,Anulekh Babu,Joseph Sebastian 대한암예방학회 2015 Journal of cancer prevention Vol.20 No.4

Background: The role of tumour inflammation and the dysplastic epithelial-stromal interactions on the nature of collagen fibres in the extracellular matrix of dysplastic epithelium is not fully understood. The present study was aimed to evaluate and compare the inflammation and pathological stromal collagen (loosely packed thin disorganized collagen) present in mild, moderate and severe epithelial dysplasias with that of inflammatory fibrous hyperplasias. The basement membrane intactness of epithelial dysplasias was also evaluated to determine if dysplastic epithelial mesenchymal interaction has any role in the integrity of stromal collagen in epithelial dysplasia. Methods: Oral epithelial dysplasias, inflammatory fibrous hyperplasia and normal oral mucosal samples were used for the study. Packing, thickness and orientation of collagen fibres in mild, moderate and severe grades of oral epithelial dysplasias (n = 24), inflammatory fibrous hyperplasia (n = 8) and normal oral mucosal samples (n = 8) were analysed based on the polarisation of collagen fibres in picrosirius red polarising stain under polarising microscope. Results: All the grades of epithelial dysplasias showed greenish yellow birefringence confirming the presence of loosely arranged pathological collagen in the presence of moderate inflammation. All the cases of inflammatory fibrous hyperplasia showed red polarisation hue and moderate inflammation. A statistically significant difference was found in the packing and orientation of collagen when epithelial dysplasias and inflammatory fibrous hyperplasia were compared (P < 0.01). When the intactness of basement membrane integrity was compared in all the groups of epithelial dysplasia, a statistically significant result was obtained (P < 0.05). Conclusions: Presence of significant amount of loosely packed thin disoriented collagen even in mild epithelial dysplasia suggests that tumourigenic factors are released to connective tissue stroma much earlier than expected. Hence we suggest considering the integrity of extracellular matrix collagen, intactness of basement membrane and inflammation associated with dysplasia along with the anaplasia of epithelial cells in the microscopic assessment of dysplastic epithelium.

Deforestation and the Garo Women of Modhupur Garh, Bangladesh

Soma Dey 숙명여자대학교 아시아여성연구원 2008 Asian Women Vol.24 No.3

Garos have been considered as the earliest inhabitants of Modhupur Garh forest. In the matrilineal society of Garos, women play the role of major provider of their family sustenance through exploiting biological resources of the forest. But the degradation of natural sal forest, which has become severe after the liberation war of Bangladesh, has made their task difficult. They are trying hard to cope with the degrading status of sal forest. Various changes have already taken place in their traditional societal structure and economy. The present study tries to focus on the negative and positive outcomes of deforestation in the life of the indigenous women.

GLYCEROL-MODIFIED POLY(ε-CAPROLACTONE)

Soma Chakraborty,James Nicole Pagaduan 한국고분자학회 2016 한국고분자학회 학술대회 연구논문 초록집 Vol.41 No.2