http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Jeon, So-Ye,Hwang, Kyung-A,Choi, Kyung-Chul Elsevier 2016 The Journal of steroid biochemistry and molecular Vol.158 No.-
<P><B>Abstract</B></P> <P>As the primary female sex steroid hormones, estrogens and progesterone play important roles to regulate growth, differentiation, and function of a broad range of target tissues in the human body and maintain the function of female reproductive tissues. Ovarian cancer is the most cause of cancer death in gynecological malignancy. Despite enormous outcomes in the understanding of ovarian cancer pathology, this disease has resulted in poor survival rates since most patients are asymptomatic until the disease has been metastasized. The exact molecular events leading to metastasis of ovarian tumor cells have not yet been well elucidated, although it is recognized that the acquisition of capacity for migration and invasiveness would be a necessary prerequisite. During metastasis, epithelial–mesenchymal transition (EMT) is an important process, in which epithelial cells lose their intracellular adhesion and cell polarity and acquire increased motility and invasive properties to become mesenchymal like cells. The process of cancer cells to undergo EMT is regulated through the up- and down- regulation of a multiple cellular markers and signaling proteins. In this review, we focused the roles of women sex steroid hormones, estrogen and progesterone, in ovarian cancer, especially the ovarian cancer undergoing EMT and metastatic process. All things considered, we may suggest that progesterone is a potent hormone which inhibits the growth of human ovarian cancer cells and development to metastasis whereas estrogen may act as a risk factor of ovarian cancer progression and that progesterone therapy may be an alternative clinically effective tool for the treatment of human ovarian cancer.</P> <P><B>Highlights</B></P> <P> <UL> <LI> During metastasis, EMT is an important process. </LI> <LI> In ovarian cancer progression, E2 and P4 have some roles via their receptors. </LI> <LI> Ovarian cancer undergoing EMT and metastatic process has been reviewed. </LI> </UL> </P>
Jeon, So-Ye,Hwang, Kyung-A,Kim, Cho-Won,Jeung, Eui-Bae,Choi, Kyung-Chul SPANDIDOS PUBLICATIONS 2017 MOLECULAR MEDICINE REPORTS Vol. No.
<P>Embryonic stem (ES) cells are pluripotent stem cells derived from a developmental stage of pre-implanted embryos. The present study investigated the effect of female sex steroid hormones on the characteristics of human ES cells by using a feeder-free culture protocol. In a feeder-free condition without sex hormones, human ES cells assumed the form of tightly packed cells that grow in a monolayer. The cells had clean and defined edges with no evidence of differentiation and expressed several markers specific for undifferentiated ES cells including POU class 5 homeobox 1 (POU5F1), sex determining region Y-box 2 (SOX2) and NANOG homeobox (NANOG). It was then investigated if female sex steroid hormones including 17 beta-estradiol (E2) and progesterone (P4) altered the protein expression of epithelial-mesenchymal transition (EMT) associated markers in addition to pluripotency markers including POU5F1, SOX2 and NANOG in human ES cells. The protein expression levels of N-cadherin, Snail and Slug were increased while E-cadherin expression was decreased by treatment of E2 or P4, and the expression levels of POU5F1, SOX2 and NANOG were decreased by the treatment of E2 or P4. When E2 and P4 were treated in combination with an estrogen receptor inhibitor (ICI 182,780) and progesterone receptor inhibitor (RU486) respectively, their effects on EMT and pluripotency of ES cells were restored to control levels. The results suggested that E2 and P4 may regulate EMT and pluripotency of human ES cells by mediating their receptors. The present study may aid in the understanding of the role of sex steroid hormones in the cellular biology of human ES cells.</P>
So-On Park,Ye-Jeon Lim,Sang-Gyoung Lee,Byung-Sik Lee 한국방사성폐기물학회 2022 한국방사성폐기물학회 학술논문요약집 Vol.20 No.1
In this study, the current situation of recycling domestic and foreign metal clearance waste was reviewed to suggest the optimal recycling scenario for metal clearance waste that occurs the most when decommission nuclear power plants. Factors that can directly or indirectly affect the recycling of metal clearance waste were analyzed and evaluation criteria that can be used to evaluate optimal recycling measures were prepared. Using this, a scenario for recycling the optimal metal clearance waste suitable for the domestic environment was proposed. As a result of comparing/reviewing the importance of the first level of the evaluation criteria, public acceptance, national policy, and regulatory requirements were evaluated as the most important ones, and recycling acceptance and regulatory requirements were evaluated as the most important the second level of evaluation criteria. As a result of reviewing the clearance waste recycling scenario, it was evaluated that unrestricted recycling scenario was preferred. This may be because the survey subjects are composed of experts in the nuclear power field, so they know recycling of clearance waste in general industries does not significantly affect radiation safety. However even if it is clearance waste, the public may feel reluctant to recycle just because it was discharged from nuclear power plants, so policy and institutional improvements are needed to reassure the public along with the scientific safety of clearance waste. In addition, in order to improve public acceptance, it seems necessary to prepare specific measures to ensure the participation of public in the entire decommissioning process, share related information, and disclose all routes from generation to disposal of decommissioning waste. Considering that research on domestic clearance waste recycling options has not been activated, this study is significant in that it derives a scenario for recycling metal clearance waste that can be implemented. Also, it is expected that the evaluation criteria derived from this study will be used significantly when establishing a radioactive waste management strategy.
Dong-Jin Kim,Ye-Jeon Lim,So-On Park,Seong-Hyeon Lee,Byung-Sik Lee 한국방사성폐기물학회 2022 한국방사성폐기물학회 학술논문요약집 Vol.20 No.2
The decommissioning of Kori Unit 1 is expected to generate a large amount of clearance waste. Disposing of a large amount of clearance waste is economically costly, so a recycling method has emerged. However, clearance waste recycling is expected to cause many conflicts among various stakeholders. In the previous study, possible conflicts were selected in consideration of the domestic environment and major issues. Based on this, this study classifies stakeholders involved in conflicts by group, and suggests ways to enhance understanding by stakeholder and enhance reliability. In this study, stakeholders are classified into four groups that share the same conflicts, and each of the following measures is suggested. 1) Stakeholder Engagement. 2) Common understanding of radiation risks, dialogue between the public/recycling industry/ regulatory agency. 3) Incentives to promote recycling clearance waste. 4) Reliable outlet store for recyclable clearance waste. The above understanding enhancement measures are presented so that a solution to conflict can be smoothly derived when designing a clearance waste-related consultative body composed of interested parties in the future. As a more specific solution, measures to enhance stakeholder trust can be suggested for each understanding enhancement measure. Reliability enhancement measures are also presented so that they can be applied to each stakeholder group, and these are as follows. 1) Write a stakeholder engagement plan, Measures for stakeholder participation in measuring the radioactivity concentration of clearance waste. 2) Active use of easy-to-understand radioactivity comparison data, Expansion of information on environmental radiation dose to public, nuclear/radiation education, Held a tour event at the nuclear power plant decommissioning site, New website for clearance waste information disclosure. 3) Incentives for recycling industries in which the Ministry of Environment or KHNP partially bears the losses that occur when the sales rate is low. Incentives are provided to consumers by including recyclables of clearance waste for Green Card’s green consumption points. 4) Online outlets open for recyclable clearance waste with easy-to-understand radioactivity comparison data. It is expected that if the above-mentioned reliability enhancement measures are used, it will be possible to secure the trust of stakeholders and reduce the gap between stakeholders in the future clearance-related consultative body.