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Smriti Sinha,Swati Mittal,Rupali Roy 대한파킨슨병및이상운동질환학회 2021 Journal Of Movement Disorders Vol.14 No.3
There is an extensive debate on the neurological consequences of 2019 novel coronavirus disease (COVID-19) and its impact on Parkinson’s disease (PD) patients, which seems to puzzle neurologists. Links between viral infections and PD have long been suspected and studied, but the exact relationship remains elusive. Since severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enters the brain through multiple routes and has a direct impact on the brain, cumulative damage occurs due to the activation of proinflammatory cytokines and chemokines. SARS-CoV-2 seems to aggravate PD due to its effects on α-synuclein, mitochondrial dysfunction, and dopamine depletion. A few studies have even highlighted the higher vulnerability of PD patients to COVID-19. The sudden dramatic change in lifestyle caused by the pandemic and the widespread lockdowns that were implemented have added to the hidden sorrows of PD patients, as they already have a compromised mechanism for coping with stress. This review summarizes insights from basic science and the clinical effect of SARS-CoV-2 infection on the human brain, with a specific focus on PD.
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Image Visual Description Model
Rishabh Kanodiya,Smriti Mittal,Shikha Jain 대한전자공학회 2020 IEIE Transactions on Smart Processing & Computing Vol.9 No.2
Image captioning is a keen area of interest for many researchers. With the evolution of machine learning and deep learning, different models are being applied to improve the accuracy and time complexity of the model. However, further improvement in terms of accuracy and time complexity is still an open research challenge. This paper’s contribution is twofold. First, we propose an image captioning model (ImgCap) using a VGG16 Convolution Neural Network and Gated Recurrent Unit (GRU) to generate the captions. Next, a similarity metric (SimM) is proposed in order to compare the generated captions with the expected ones. Furthermore, the proposed model is compared with an existing Long Short-Term Memory (LSTM)-based model. We observe that the proposed model outperforms the existing one in terms of both accuracy and time complexity.
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( Hoda Aayadi ),( Smriti P. K. Mittal ),( Anjali Deshpande ),( Makarand Gore ),( Saroj S. Ghaskadbi ) 생화학분자생물학회(구 한국생화학분자생물학회) 2017 BMB Reports Vol.50 No.11
Geraniin, a hydrolysable tannin, used in traditional medicine in Southeast Asia, is known to exhibit various biological activities. As an antioxidant it is known to up-regulate phase II enzyme Heme oxygenase-1 (HO-1). However its mechanism is not clearly understood. Nuclear factor erythroid-derived 2 related factor 2 (Nrf-2) is transcriptionally up-regulated by Extracellular signal-regulated kinase (ERK) 1/2 and retained in nucleus due to inactivated Glycogen synthase kinase 3 beta (GSK-3β). Geraniin additionally down-regulates expression of microRNA 217 and 377 (miR-217 and miR-377) which target HO-1 mRNA. Expression of BTB and CNC homolog 1 (BACH-1), another regulator of HO-1, is also down-regulated by up-regulating microRNA 98 (miR-98), a negative regulator of BACH-1. Thus, geraniin up-regulates HO-1 expression both through activating its positive regulator Nrf-2 and by down-regulating its negative regulator BACH-1. Up-regulation of HO-1 also confers protection to HepG2 cells from tertiary butyl hydroperoxide (TBH) induced cytotoxicity. [BMB Reports 2017; 50(11): 560-565]
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