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        Electrochemical evaluation of naproxen through Au@f-CNT/GO nanocomposite in environmental water and biological samples

        Krishnapandi Alagumalai,Sivakumar Musuvadhi Babulal,Shen-Ming Chen,Ragurethinam Shanmugam,Johnbosco Yesuraj 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.104 No.-

        The cytotoxic dosage of exposed drug waste is frequently discharging on aquatic surfaces via wastewatertreatment plants and pharma industries. Early detection of these drug wastes with a reliable and accurateare in great need. In this report, a noble metal effectively doped on oxidized one-dimensional (1D) singlewalledcarbon nanotube and abundant oxygen functional groups presenting two-dimensional (2D) grapheneoxide on its surface, and hydrophobic cavities are the promising selector towards electrochemicaloxidation of Naproxen (NPZ). A hybrid nanocomposite Au@f-CNT/GO was engineered by the ultrasoundassistsonication method and employed for the ultra-quantification of the therapeutic drug NPZ. In addition,various physicochemical and analytical techniques were utilized to confirm the successful formationof composite and principal detection of NPZ. Au@f-CNT/GO fabricated glassy carbon electrode exhibits alow resistance and higher electrocatalytic activity toward NPZ sensing. In addition, under the optimizedcondition, the sensor demonstrates an acceptable linear range of 100 nM 15.6 mM, a lower limit ofdetection of 14 nM (S/N = 3), and higher sensitivity of 1.7484 lA lM 1 cm2. Furthermore, the proposedsensor has high selectivity, stability, reproducibility, and repeatability. Moreover, real sample analysisshows appreciable recovery results of 96 to 99% which strongly suggests that the proposed sensor haspotential applicability for the sensitive detection of NPZ in the various water and biological samples.

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