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- 저자 : Siva Swapna Kasarla (검색결과 1 건)
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Interplay of Vitamin D and CYP3A4 Polymorphisms in Endocrine Disorders and Cancer
Siva Swapna Kasarla,Vannuruswamy Garikapati,Yashwant Kumar,Sujatha Dodoala 대한내분비학회 2022 Endocrinology and metabolism Vol.37 No.3
Vitamin D has received considerable optimistic attention as a potentially important factor in many pathological states over the past fewdecades. However, the proportion of the active form of vitamin D metabolites responsible for biological activity is highly questionablein disease states due to flexible alterations in the enzymes responsible for their metabolism. For instance, CYP3A4 plays a crucial rolein the biotransformation of vitamin D and other drug substances. Food-drug and/or drug-drug interactions, the disease state, geneticpolymorphism, age, sex, diet, and environmental factors all influence CYP3A4 activity. Genetic polymorphisms in CYP450-encodinggenes have received considerable attention in the past few decades due to their extensive impact on the pharmacokinetic and dynamicproperties of drugs and endogenous substances. In this review, we focused on CYP3A4 polymorphisms and their interplay with vitamin D metabolism and summarized the role of vitamin D in calcium homeostasis, bone diseases, diabetes, cancer, other diseases, anddrug substances. We also reviewed clinical observations pertaining to CYP3A4 polymorphisms among the aforementioned diseaseconditions. In addition, we highlighted the future perspectives of studying the pharmacogenetics of CYP3A4, which may have potential clinical significance for developing novel diagnostic genetic markers that will ascertain disease risk and progression.
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