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- 저자 : Siqin Yang (검색결과 3 건)
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Significance of Hertwig’s Epithelial Root Sheath
Siqin Yang,조의식 대한구강해부학회 2015 대한구강해부학회지 Vol.36 No.1
As tooth crown formation completes and root formation begins, the inner and outer enamel epithelial cells proliferate from the cervical loop of the enamel organ to form a continuous sheath containing double layer of cells, which is known as Hertwig's epithelial root sheath (HERS). Through reciprocal epithelial-mesenchymal interactions, HERS plays an important role in root development, including root morphogenesis (root size, shape and number), dentinogenesis and cemetogenesis. However, the precise nature of this role remains unclear. At later stage of root development, following the formation of first radicular mantle dentin, HERS fragments into discrete clusters of cells and migrate away from the root to the region of future periodontal ligament, which form the epithelia cell rests of Malassez (ERM).
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Haitao Li,Yang Sun,최형진,Siqin Zhao 한국고분자학회 2018 Macromolecular Research Vol.26 No.9
Hierarchical architectures of poly(methyl methacrylate) (PMMA)/aminofunctionalized multi-walled carbon nanotube (MWNT-NH2) particles were prepared, in which the electrical conductive network was constructed on the surface of PMMA microspheres. The morphology, composition, and electrical conductivity of the particles were characterized by transmission electron microscopy, Fourier transform infrared spectroscopy, scanning electron microscopy, thermogravimetric analysis, and four-probe electrical conductivity measurement. The PMMA/MWNT-NH2 transducers were exposed to each ethanol, water, toluene, and chloroform for volatile organic compounds (VOCs) sensing detection. The particles showed excellent sensitivity, good reversibility, and a strong response compared to the raw MWNTs and MWNT-NH2. This was attributed not only to the formation of a charge transmission path on the particle surface, but also to the interaction between the vapor molecules and functionalized MWNTs. The enhanced sensing performance of the PMMA/MWNT-NH2 particles suggests that it is a good candidate for the preparation of electronic noses for disease diagnostics and VOCs detection.
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Nfic regulates tooth root patterning and growth
Tak-Heun Kim,Cheol-Hyeon Bae,Siqin Yang,Joo-Cheol Park,Eui-Sic Cho 대한해부학회 2015 Anatomy & Cell Biology Vol.48 No.3
Molecular interactions between epithelium and mesenchyme are important for root formation. Nuclear factor I-C (Nfic) has been identified as a key regulator of root formation. However, the mechanisms of root formation and their interactions between Hertwig’s epithelial root sheath (HERS) and mesenchyme remain unclear. In this study, we investigated the role of Nfic in root patterning and growth during molar root development. The molars of Nfic knockout mice exhibited an enlarged pulp chamber and apical displacement of the pulpal floor, characteristic features of taurodontism, due to delayed furcation formation. In developing molar roots of mutant mice at P14, BrdU positive cells decreased in the apical mesenchyme of the elongation region whereas those cells increased in the dental papilla of the furcation region. Whereas cytokeratin 14 and laminin were localized in HERS cells of mutant molars, Smoothened (Smo) and Gli1 were downregulated in preodontoblasts. In contrast, cytokeratin 14 and Smo were localized in the cells of the furcation region of mutant molars. These results indicate that Nfic regulates cell proliferation in the dental mesenchyme and affects the fate of HERS cells in a site-specific manner. From the results, it is suggested that Nfic is required for root patterning and growth during root morphogenesis.
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