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Efficacy of an oral hyaluronate and collagen supplement as a preventive treatment of elbow dysplasia
Simón Martí-Angulo,Núria García-López,Ana Díaz-Ramos 대한수의학회 2014 Journal of Veterinary Science Vol.15 No.4
One hundred and five Labrador dogs were randomlydivided into two groups to determine the number of animalsthat develop elbow dysplasia when treated with an oralsupplement compared to untreated ones. Efficacy of the oraltreatment was also evaluated once illness was diagnosed. The supplement (Hyaloral) contained hyaluronic acid,hydrolysed collagen, glucosamine, chondroitin sulphate,and gamma oryzanol. Clinical evaluation of the elbow jointswas completed at months 3, 6, 12, and 20 by orthopaedicevaluations, radiography, serologic and blood analysis, andveterinarian evaluation of dysplasia symptoms. All sideeffects were recorded. In the control group, 33.3% of thedogs developed radiographic evidence of elbow dysplasiacompared to 18.5% in the treated group. Symptoms ofdysplasia at 12 months differed between the treated (12.5%)and control (61.5%) animals, and were significantlydifferent at 20 months (p < 0.05). Differences in lamenessalong with movement and swelling of the elbows betweengroups were observed after 12 months. The treated grouphad improved significantly by the last visit (p < 0.05). Noadverse side effects were reported. In conclusion, oraltreatment with Hyaloral may have a potential cumulativeaction that provides protection against dysplasia and significantly improves symptoms of elbow dysplasia.