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        Copper- and Zinc-Enriched Mycelium of Agaricus blazei Murrill: Bioaccumulation and Bioavailability

        Nestor Curvetto,Maia Rabinovich,Debora Figlas,Silvia Delmastro 한국식품영양과학회 2007 Journal of medicinal food Vol.10 No.1

        Agaricus blazeiis an edible mushroom with medicinal properties. To obtain organic combinations of poten-tial utility as a food dietary supplement, the accumulation and potential bioavailability of copper (Cu) and zinc (Zn) onmycelium grown in the presence of these metals were studied. At 400 ppm, the mycelium accumulated 449 and 163 timesthe basal content of Cu and Zn, respectively. When mycelia cultivated with nonmycotoxic concentrations of Cu or Zn (100and 200 ppm) were subjected to sequential chemical extraction and simulated gastrointestinal digestion, close to 90% of themetals accumulated in the available nonresidual fraction, which was similar to or better than the values found in two com-mercial supplements. The solubility in the simulated digestive fluids was 3034% and 1833%, i.e., 6098% and 911% ofthe recommended daily intake for Cu and Zn, respectively, with only 1 g of mycelium.

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