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( Si Mei Qing ) 한국정치평론학회 2012 정치와 평론 Vol.11 No.-
Arc of Empire focuses on America`s four wars in Asia - in the Philippines, against Japan, in Korea, and in Vietnam -, and the problem of empire. For the first time in the Western literature, these four wars were not treated as ``separate and unconnected.`` Rather, they were considered as “phases in a U.S. attempt to establish and maintain a dominant position in eastern Asia sustained over some seven decades against considerable resistance.” Furthermore, for the first time in the Western literature, the authors tackles “the tough issues of what happens when an imperial project collapses and of what insights the U.S. Asian imbroglio offers on the current U.S. involvement in the Middle East and Central Asia.” This book should have important and far-reaching implications for current American debates on US foreign policy toward East Asia or the new security strategy of ``returning to Asia.``
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Cai, Si-Qing,Yan, Jian-Xiang,Chen, Qing-Shi,Huang, Mei-Ling,Cai, Dong-Lu Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.9
Background: Full-field digital mammography (FFDM) with dense breasts has a high rate of missed diagnosis, and digital breast tomosynthesis (DBT) could reduce organization overlapping and provide more reliable images for BI-RADS classification. This study aims to explore application of COMBO (FFDM+DBT) for effect and significance of BI-RADS classification of breast cancer. Materials and Methods: In this study, we selected 832 patients who had been treated from May 2013 to November 2013. Classify FFDM and COMBO examination according to BI-RADS separately and compare the differences for glands in the image of the same patient in judgment, mass characteristics display and indirect signs. Employ Paired Wilcoxon rank sum test was used in 79 breast cancer patients to find differences between two examine methods. Results: The results indicated that COMBO pattern is able to observe more details in distribution of glands when estimating content. Paired Wilcoxon rank sum test showed that overall classification level of COMBO is higher significantly compared to FFDM to BI-RADS diagnosis and classification of breast (P<0.05). The area under FFDM ROC curve is 0.805, while that is 0.941 in COMBO pattern. COMBO shows relation of mass with the surrounding tissues, the calcification in the mass, and multiple foci clearly in breast cancer tissues. The optimal sensitivity of cut-off value in COMBO pattern is 82.9%, which is higher than that in FFDM (60%). They share the same specificity which is both 93.2%. Conclusions: Digital Breast Tomosynthesis (DBT) could be used for the BI-RADS classification in breast cancer in clinical.
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시메이칭 ( Si Mei Qing ),김민혁(역) 한국정치평론학회 2010 정치와 평론 Vol.7 No.-
In the post-Cold War world, there have been competing policy blueprints for Northeast Asia among Asian and American academics and policymakers, each of which centers on the role of the Korean Peninsula. One is a system of balance of power in Northeast Asia, wherein the US policy goal toward North Korea is regime change through intensified economic sanctions and military pressures. Another is a system of collective security in Northeast Asia, wherein the US policy goal toward North Korea is eventual diplomatic normalization. Still the other is Northeast Asian Economic Community and regionalism, wherein US economic embargo against North Korea should be lifted, and a reunified Korea based on the principles of the Sunshine Policy would become the heart of Northeast Asian economic integration and regionalism. At this historic moment, whether the strategic choices in Northeast Asia - the Korean Peninsula, Japan, and China - are driven by the current events, and thus make near-sighted reactions to the chains of events, or whether the choices are founded upon the long-term goal of regional cooperation and integration, will have enormous impacts on the people of the Korean Peninsula and Northeast Asia, as well as on the future development of Sino-American relations.
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한반도에서 미국과 중국의 대결: 위기의 시대에 양국은 서로를 어떻게 평가했는가?
시메이 ( Mei Qing Si ),김기근 한국정치평론학회 2012 정치와 평론 Vol.10 No.-
Before the outbreak of the Korean War, neither Washington nor Beijing intended to engage in a war with the other. By the end of 1950, China and the United States were at war in Korea. In a time of crisis, how did both sides assess each other`s intentions? What historical lessons can we draw from the U.S.-China military confrontation in the Korean crisis? In an attempt to answer these questions, this essay will examine the shift in the Truman administration`s military strategy from the adoption of the defensive perimeter to the decision to cross the 38th parallel in Korea. Doing so will provide important insights on the legacy of President Harry S. Truman in Northeast Asia.
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Cui, Yan-Hui,Liang, Hai-Jun,Zhang, Qing-Qin,Li, Si-Qing,Li, Xiao-Rui,Huo, Xiao-Qing,Yang, Qing-Hui,Li, Wei-Wei,Gu, Jian-Fa,Hua, Qin-Liang,Lu, Ping,Miao, Zhan-Hui Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.4
Objective: To explore the effect on radiosensitivity of arsenic trioxide ($As_20_3$) in conjunction with hyperthermia on the esophageal carcinoma EC-1 cell line. Method: Inhibition of EC-1 cell proliferation at different concentrations of $As_20_3$ was assessed using the methyl thiazolyl blue colorimetric method (MTT method), with calculation of $IC_{50}$ value and choice of 20% of the $IC_{50}$ as the experimental drug concentration. Blank control, $As_20_3$, hyperthermia, radiotherapy group, $As_20_3$ + hyperthermia, $As_20_3$ + radiotherapy, hyperthermia + radiotherapy and $As_20_3$ + hyperthermia + radiotherapy groups were established, and the cell survival fraction (SF) was calculated from flat panel colony forming analysis, and fitted by the 'multitarget click mathematical model'. Flow cytometry (FCM) was used to detect changes in cell apoptosis and the cell cycle. Results: $As_20_3$ exerted inhibitory effects on proliferation of esophageal carcinoma EC-1 cells, with an $IC_{50}$ of 18.7 ${\mu}mol/L$. After joint therapy of $As_20_3$ + hyperthermia + radiotherapy, the results of FCM showed that cells could be arrested in the $G_2$/M phase, and as the ratio of cells in $G_0/G_1$ and S phases decreased, cell death became more pronounced. Conclusion: $As_20_3$ and hyperthermia exert radiosensitivity effects on esophageal carcinoma EC-1 cells, with synergy in combination. Mechanistically, $As_20_3$ and hyperthermia mainly influence the cell cycle distribution of EC-1 esophageal carcinoma cells, decreasing the repair of sublethal damage and inducing apoptosis, thereby enhancing the killing effects of radioactive rays.
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Thiazinogeldanamycin, a New Geldanamycin Derivative Produced by Streptomyces hygroscopicus 17997
( Si Yang Ni ),( Lin Zhuan Wu ),( Hong Yuan Wang ),( Mao Luo Gan ),( Yu Cheng Wang ),( Wei Qing He ),( Yi Guang Wang ) 한국미생물 · 생명공학회 2011 Journal of microbiology and biotechnology Vol.21 No.6
A new geldanamycin (GDM) derivative was discovered and isolated from the fermentation broth of Streptomyces hygroscopicus 17997. Its chemical structure was elucidated as thiazinogeldanamycin by LC-MS, sulfur analysis, and NMR. The addition of cysteine to the fermentation medium significantly stimulated the production level of thiazinogeldanamycin, suggesting cysteine as a precursor of thiazinogeldanamycin production. Although showing a decreased cytotoxicity against HepG2 cancer cells, thiazinogeldanamycin exhibited an improved water solubility and photostability. Thiazinogeldanamycin may represent the first natural GDM derivative characterized so far that uses GDM as its precursor. Its appearance also clearly indicates that an appropriate end-point of fermentation is of critical importance for the maximal production of GDM by Streptomyces hygroscopicus 17997.
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Si-Qi Tang,Ling-Long Tang,Yan-Ping Mao,Wen-Fei Li,Lei Chen,Yuan Zhang,Ying Guo,Qing Liu,Ying Sun,Cheng Xu,Jun Ma 대한암학회 2021 Cancer Research and Treatment Vol.53 No.2
Purpose The occurrence pattern of immune-related adverse events (irAEs) induced by immune checkpoint inhibitor (ICI) in cancer treatment remains unclear. Materials and Methods Phase II-III clinical trials that evaluated ICI-based treatments in cancer and were published between January 2007 and December 2019 were retrieved from public electronic databases. The pooled median time to onset (PMT-O), resolution (PMT-R), and immune-modulation resolution (PMT-IMR) of irAEs were generated using the metamedian package of R software.Results Twenty-two eligible studies involving 23 clinical trials and 8,436 patients were included. The PMT-O of all-grade irAEs ranged from 2.2 to 14.8 weeks, with the longest in renal events. The PMT-O of grade ≥ 3 irAEs was significantly longer than that of all-grade irAEs induced by programmed cell death protein 1 (PD-1) and its ligand 1 (PD-L1) inhibitors (27.5 weeks vs. 8.4 weeks, p < 0.001) and treatment of nivolumab (NIV) plus ipilimumab (IPI) (7.9 weeks vs. 6.0 weeks, p < 0.001). The PMT-R of all-grade irAEs ranged from 0.1 to 54.3 weeks, with the shortest and longest in hypersensitivity/infusion reaction and endocrine events, respectively. The PMT-IMR of grade ≥ 3 irAEs was significantly shorter than that of all-grade irAEs caused by PD-1/PD-L1 blockade (6.9 weeks vs. 40.6 weeks, p=0.002) and NIV+IPI treatment (3.1 weeks vs. 5.9 weeks, p=0.031).Conclusion This study revealed the general and specific occurrence pattern of ICI-induced irAEs in pan-cancers, which was deemed to aid the comprehensive understanding, timely detection, and effective management of ICI-induced irAEs.
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모니터의 성능 및 캘리브레이션 지속시간 효과에 관한 연구
안시준 ( Si Joon An ),주련청 ( Lian Qing Zhu ) 한국사진학회 2009 AURA Vol.0 No.21
The reproduction and preservation of monitor is relative important in dealing with digital photograph. Unfortunately the monitor according to the maker and the model represents much difference in color reproduction and preservation. To solve this problem we need to apply CMS (Color management system) matching the color among different devices. In particular, optical device is used for calibration of monitor. It is known as common sense to preheat the monitor around 1 hour before calibration, which makes colors of monitor displayed stable. However technical progress regarding monitor might demand the change of time witch be taken colors to be displayed stable. It make the change in the time condition regarding monitor and in period for monitor to preserve colors. On this study we consider how much the reproduction of color is affected by the time which monitors that normally used display stable, which means sufficient conditions to apply calibration, and how the color is changed with time after calibration. On this study we hope that we find the performance of monitors on view of user and supply the material to manage calibration.
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Li-Qing Niu,Lu Xiao,Qiu-Han Cai,Yu-Yi Wu,Si-Yuan Hu,Sheng-Xuan Guo,Yu-Ling Tian,Qiu-Rong Wang 한국한의학연구원 2023 Integrative Medicine Research Vol.12 No.2
Background: Rotavirus enteritis (RVE) accounts for 37% of all death in children (<5 years) with diarrhea. Chinese herbal injections (CHIs) have drawn more attention from practitioners because of the valid effects for RVE. However, the most beneficial one has not yet been determined. Methods: Eight databases were searched from their inception up to September 3, 2022. The primary outcome was clinical effective rate and the secondary outcomes were time for disappearance of diarrhea, time of defervescence, time for disappearance of vomiting, and adverse drug reactions or adverse drug events. OpenBUGS 3.2.3 and STATA 14.0 software were employed to carry out the NMA. Results: 58 randomized controlled trials (RCTs) with 6436 child patients were included in this Bayesian NMA. Four CHIs were investigated including Yanhuning injection (YHN), Xiyanping injection (XYP), Reduning injection (RDN), and Zedoary Turmeric Oil injection (ZTO). The results showed that YHN [OR=6.16, 95% CI (4.39, 8.77)] had a superior effect in improving clinical effective rate compared to Ribavirin based on Western medicine (WM). According to SUCRA values, YHN (84.1%) ranked highest. As for the secondary outcomes, XYP was the better intervention in shortening the time for disappearance of diarrhea. Regarding time for defervescence, RDN had obvious advantages and also performed well in time for disappearance of vomiting. Conclusions: CHIs combined with WM could be beneficial than Ribavirin in improving clinical effective rate, and YHN was the optimum treatment. From the comprehensive evaluations of both the clinical effective rate and other outcomes, YHN also indicated a favorable therapeutic effect in RVE. Study registration: This study was registered on PROSPERO (CRD42022357149).
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