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이주호,Hlaing Shwe Phyu,caojiafu,핫산 눌하스니,유진욱 한국약제학회 2020 Journal of Pharmaceutical Investigation Vol.50 No.5
Purpose Nitric oxide (NO) has emerged as a novel agent for the treatment of infected wounds owing to its potent woundhealing effects and antibacterial activity against drug-resistant bacteria, including methicillin-resistant Staphylococcus aureus (MRSA). In this study, we developed a NO-releasing ointment composed of S-nitrosoglutathione (GSNO) and polyethylene glycol (PEG) for the treatment of MRSA-infected cutaneous wounds. Methods The GSNO-incorporated PEG ointment (GPO) was successfully prepared by homogeneous dispersion of micronized GSNO in a PEG ointment base. High encapsulation efficiency was achieved (97.25%) via water-free fabrication processing of the GPO, resulting in minimal GSNO hydrolysis. Results When applied to a wound, the wound fluid triggered the degradation of GSNO and NO was released from the GPO for 24 h without an initial burst release. The GPO exhibited potent antibacterial effects against MRSA without cytotoxic effects against L929 cells. An in vivo wound healing experiment using a mouse MRSA-challenged full-thickness wound model revealed that the GPO could facilitate healing of infected wounds. Conclusion Thus, the GPO could be a promising NO-releasing formulation for the treatment of infected cutaneous wounds.
Aruzhan Saparbayeva,Juho Lee,Shwe Phyu Hlaing,Jihyun Kim,Dongmin Kwak,Hyunwoo Kim,Eun Hee Lee,Seonghwan Hwang,Min-Soo Kim,Hyung Ryong Moon,Yunjin Jung,Jin-Wook Yoo 대한약학회 2023 Archives of Pharmacal Research Vol.46 No.7
Colon-targeted oral drug delivery systems comprising nanoparticles and microparticles have emerged as promising tools for the treatment of ulcerative colitis (UC) because they minimize side effects and maximize the local drug concentration. Dexamethasone sodium phosphate (DSP) is a potent anti-inflammatory glucocorticoid used for the treatment of UC. However, it remains a rather short-term treatment option owing to its side effects. In the present study, we developed the alginate gel encapsulating ionically bridged DSP-zinc-poly(lactic-co-glycolic acid) (PLGA) nanocomplex (DZP-NCs-in-microgel) for the oral local treatment of UC. The successful encapsulation of DSP-zinc-PLGA nanocomplex (DZP-NCs) in alginate microgel was confirmed by SEM imaging. The prepared gel released DZP-NCs in the stimulated intestinal fluid and dampened the release of DSP in the upper gastrointestinal tract. Furthermore, DZP-NCs-in-microgel alleviated colonic inflammation in a mouse model of dextran sodium sulfate-induced colitis by relieving clinical symptoms and histological marks. Our results suggest a novel approach for the oral colon-targeted delivery of dexamethasone sodium phosphate for the treatment of UC.
김지현(Jihyun Kim),쉐이 퓨 랑이(Shwe Phyu Hlaing ),이주호(Juho Lee),사파르바예바 아루잔(Aruzhan Saparbayeva ),유진욱(Jin-Wook Yoo) 대한약학회 2022 약학회지 Vol.66 No.4
The gut microbiome is a critical determinant of human health and disease status. Administration of live microorganisms has emerged as an effective way to recover damaged gut microbiome for improving host health. However, live microorganisms are susceptible to various environmental stresses, including acidic pH during the gastric transit. Thus, appropriate delivery techniques are required to protect the live microorganisms during their transit to the target area and ensure their release at a desired location such as ileum or ascending colon. In this review, we provide an overview of intestinal delivery techniques for live microorganisms.
Advances in colon-targeted nano-drug delivery systems: challenges and solutions
Muhammad Naeem,Uzma Azeem Awan,Fazli Subhan,Jiafu Cao,Shwe Phyu Hlaing,이주호,임은옥,YunJinJung,유진욱 대한약학회 2020 Archives of Pharmacal Research Vol.43 No.1
Nano-drug delivery systems (NDDS) for colontargeteddrug delivery are an active area of research onlocal diseases aff ecting the colon, such as ulcerative colitis,Crohn’s disease, colon cancer, and for the delivery of peptideor protein drugs and vaccinations. In particular, targetednano-drug delivery to the colon is advantageous for colonspecific diseases because nanoparticles can accumulate indiseased parts, improve the effi cacies of therapeutics, andenable localized treatments, which reduces systemic toxicity. However, there are many hurdles, such as burst drug release,enzyme and acidic degradation of drug and carrier in thestomach, pH variations, mucus entrapment, and systemicuptake in the upper small intestine, which could challengeand compromise the successful delivery of NDDS to thecolon. With advancements in NDDS, it may be possible toovercome these challenges leading to effi cient drug deliveryfor colon-specifi c disorders. This review describes a fewof the potential colon-specifi c drug delivery areas and thechallenges faced by colon-targeted orally administered deliverysystems, and provides an updated summary of recentadvances in the development of orally administered NDDSfor colon targeting, and the future advances in this research.