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Coactosin-like protein 1 inhibits neuronal migration during mouse corticogenesis
Guohong Li,Yupeng Yin,Jiong Chen,Yanle Fan,Juhong Ma,Yingxue Huang,Chen Chen,Pengxiu Dai,Shulin Chen,Shanting Zhao 대한수의학회 2018 Journal of Veterinary Science Vol.19 No.1
Coactosin-like protein 1 (Cotl1), a member of the actin-depolymerizing factor (ADF)/cofilin family, was first purified from a soluble fraction of Dictyostelium discoideum cells. Neuronal migration requires cytoskeletal remodeling and actin regulation. Although Cotl1 strongly binds to F-actin, the role of Cotl1 in neuronal migration remains undescribed. In this study, we revealed that Cotl1 overexpression impaired migration of both early- and late-born neurons during mouse corticogenesis. Moreover, Cotl1 overexpression delayed, rather than blocked, neuronal migration in late-born neurons. Cotl1 expression disturbed the morphology of migrating neurons, lengthening the leading processes. This study is the first to investigate the function of Cotl1, and the results indicate that Cotl1 is involved in the regulation of neuronal migration and morphogenesis.
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STRUCTURE IMPROVEMENT OF TRUCK CARRIAGE WITH SEALING COVER
Anyuan Jiao,Fulong Chen,Xiaomei Chen,Shulin Shen 한국자동차공학회 2020 International journal of automotive technology Vol.21 No.1
SolidWorks and ANSYS Workbench were used to establish solid model and perform FEM analysis of truck with and without sealing covers respectively. In the past practical production, there has been no precedent for the modal analysis of the truck carriage with a sealing cover; the modal analysis is carried out for the first time in this paper. The vibration characteristics of the truck carriage are obtained. The first ten-order of non-rigid mode of the newly development truck carriage is obtained and the excitation frequency range of the idling state of the engine is calculated to avoid resonating with the ground. In order to avoid the resonance phenomenon during the truck running, the vibration characteristics of the new carriage model were studied, the first ten non-rigid modes of the new carriage model were extracted, and the excitation frequency range of the engine during idling was calculated. The non-rigid natural frequencies of the first 10 free models are between 6.18 ~ 26.74 Hz. The engine idling excitation frequency is 32.5 ~ 145 Hz, and the common excitation frequency caused by road roughness is 3 Hz. In theory, it does not cause resonance when driving in a normal state.
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The Composition of the Rare Earth Based Conversion Coating Formed on AZ91D Magnesium Alloy
( Menglei Chang ),( Jianfeng Wu ),( Dongchu Chen ),( Shulin Ye ) 한국부식방식학회(구 한국부식학회) 2018 Corrosion Science and Technology Vol.17 No.1
As structural materials, magnesium (Mg) alloys have been widely used in the fields of aviation, automobiles, optical instruments, and electronic products. There are few studies on the effect of coating conditions on the compositional variation during the formation process of the conversion coatings. Rare-earth based conversion coating on AZ91 magnesium alloy was prepared in ceric sulfate and hydrogen peroxide contained solution. The element composition and valence as well as their distribution in the coating were analyzed with energy dispersive X-ray spectroscopy (EDS), Electron probe micro-analyzer (EPMA), X-ray photoelectron spectroscopy (XPS). The effect of treating process on the element composition were also studied. It was found that the conversion coating surface consists of Mg, Al, O, Ce, and the weight content of Ce in the coating was affected by the treating solution concentration and immersion time; the Ce element was distributed in the coating non-uniformly and existed in the form of Ce<sup>+3</sup> and Ce<sup>+4</sup>, while the O element existed in the form of OH<sup>-</sup>, O<sup>2-</sup>, H<sub>2</sub>O. Based on microscopic analysis results, the electrochemical deposition mechanism on the micro-anode and micro-cathode in the process of the coating growth was suggested.
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Zhengyang Kang,Yonghong Fu,Yun Chen,Jinghu Ji,Hao Fu,Shulin Wang,Rui Li 한국정밀공학회 2018 International Journal of Precision Engineering and Vol.5 No.5
Tool-chip adhesion impacts on cutting performance significantly, especially in finish cutting process. To promote cutting tools’ anti-adhesion property, the concave micro-grooves texture (MGT) and convex volcano-like texture (VLT) were fabricated separately on lathe tools’ rake faces by laser surface texturing (LST). Various orientations of MGT and different area densities (9% and 48%) and regions (partial and full) of VLT were considered in textured patterns designing. The following orthogonal cutting experiments, machining of aluminum alloy 5038, analyzed tools’ performances including cutting force, cutting stability, chip shape, rake face adhesion and abrasion. It indicated that under dry finish cutting conditions, MGT contributed to cutting stability and low cutting forces, meanwhile friction and normal force reduced by around 15% and 10%, respectively with a weak correlation to the grooves’ orientation. High density VLT tools, on the other hand, presented an obvious anti-adhesion property. A 5 µm reduction of crater wear’s depth can be observed on textured rake faces after long length cutting and textured rake faces presented half size of BUE regions comparing to the flat tool, however, once the texture morphologies were filled or worn, the anti-adhesion effect could be invalid. The bearing ratio curve was employed to analysis tool-chip contact and durability of textured surfaces contributing to a better understanding of anti-adhesion and enhanced durability of the textured tools.
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