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HVEM is a TNF Receptor with Multiple Regulatory Roles in the Mucosal Immune System
Shui, Jr-Wen,Kronenberg, Mitchell The Korean Association of Immunobiologists 2014 Immune Network Vol.14 No.2
The herpes virus entry mediator (HVEM) is a member of the tumor necrosis factor receptor superfamily (TNFRSF), and therefore it is also known as TNFRSF14 or CD270 (1,2). In recent years, we have focused on understanding HVEM function in the mucosa of the intestine, particularly on the role of HVEM in colitis pathogenesis, host defense and regulation of the microbiota (2-4). HVEM is an unusual TNF receptor because of its high expression levels in the gut epithelium, its capacity to bind ligands that are not members of the TNF super family, including immunoglobulin (Ig) superfamily members BTLA and CD160, and its bi-directional functionality, acting as a signaling receptor or as a ligand for the receptor BTLA. Clinically, Hvem recently was reported as an inflammatory bowel disease (IBD) risk gene as a result of genome wide association studies (5,6). This suggests HVEM could have a regulatory role influencing the regulation of epithelial barrier, host defense and the microbiota. Consistent with this, using mouse models, we have revealed how HVEM is involved in colitis pathogenesis, mucosal host defense and epithelial immunity (3,7). Although further studies are needed, our results provide the fundamental basis for understanding why Hvem is an IBD risk gene, and they confirm that HVEM is a mucosal gatekeeper with multiple regulatory functions in the mucosa.
Hydrothermal Synthesis, Crystal Structure of Four Novel Complexes Based on Thiabendazole Ligand
Shui-Qiang Wei,Cui-Wu Lin,Xian-Hong Yin,Yue-Jiao Huang,Pei-Qi Luo 대한화학회 2012 Bulletin of the Korean Chemical Society Vol.33 No.9
Four novel metal–organic complexes [Cd2(IP)2(TBZ)2(H2O)2]·(H2O) (1), [Zn4(IP)4(TBZ)4]·2(H2O) (2), [Zn2(BTC)(TBZ)2(CO2H)] (3), [Co(PDC)(TBZ)] (4) (where IP = isophthalate; TBZ = thiabendazole; BTC = 1,3,5-benzenetricarboxylate; PDC = pyridine-3,4-dicarboxylate) have been prepared and characterized by IR spectrum, elemental analysis, thermogravimetric analysis, and single-crystal X-ray diffraction. X-ray structure analysis reveals that 1, 2, and 3 are one-dimensional chain polymers, while 4 is a two-dimensional network polymer. The TBZ acts as a typical chelating ligand coordinated to the metal center in all complexes. The 1D chain architecture of 1 is constructed from isophthalates and cadmium atoms. A simultaneous presence of chelating, monodentate and bidentate coordination modes of IP ligands is observed in complex 2. In complex 3, the 16-membered rings are alternately arranged forming an infinite 1D double-chain structure. The 2D skeleton of 4 is formed by cobalt ions as nodes and PDC dianions as spacers, through coordination bonds. The hydrogen bonds and π-π stacking play important roles in affecting the final structure where complexes 1 and 3 have 2D supramolecular networks, while complexes 2 and 4 have 3D supramolecular architectures.
Shui Wang,Qun-Sheng Li,Zhao Li 한국화학공학회 2007 Korean Journal of Chemical Engineering Vol.24 No.2
using a laser technique in the temperature range from 283.15 to 323.15 K. The results were correlated with a semi-empirical equation. The experimental solubility and correlation equation in this work can be used as essential data andmodels in the purification process of 4-(3,4-dichlorophenyl)-1-tetralone.
Shui Wang,Qun-Sheng Li,Zhao Li 한국화학공학회 2008 Korean Journal of Chemical Engineering Vol.25 No.3
The solubility of 4-(3,4-dichlorophenyl)-1-tetralone in eleven alcohols (methanol, ethanol, 1-propanol, 1- butanol, 1-pentanol, 1-hexanol, 2-propanol, 2-butanol, 2-pentanol, 1,2-propanediol, 1,3-propanediol) was measured by using a laser technique with a temperature range from 283 K to 323 K, and at atmospheric pressure. For mono n-alcohols, the solubility is the lowest in methanol, increasing with the carbon chain of the alcohols. The results were correlated with a semi-empirical equation. The experimental solubility and correlation equation in this work can be used as essential data and models in the purification process of 4-(3,4-dichlorophenyl)-1-tetralone.
Urokinase Inhibitor Design Based on Pharmacophore Model Derived from Diverse Classes of Inhibitors
Shui, Liu,Bharatham, Nagakumar,Bharatham, Kavitha,Lee, Keun-Woo Korean Society for Bioinformatics and Systems Biol 2006 Bioinformatics and Biosystems Vol.1 No.2
A three-dimensional pharmacophore model was developed based on 24 currently available inhibitors, which were rationally selected from 472 compounds with diverse molecular structure and bioactivity, for generating pharmacophore of uPA (Urokinase Plasminogen Activator) inhibitors. The best hypothesis (Hypo1) comprised of five features, namely, one positive ionizable group, one hydrogen-bond acceptor group and three hydrophobic aromatic groups. The correlation coefficient, root mean square deviation and cost difference were 0.973, 0.695, and 94.291 respectively, suggesting that a highly predictive pharmacophore model was successfully obtained. The application of the model showed great success in predicting the activities of 251 known uPA inhibitors (test set) with a correlation coefficient of 0.837, and there was also none of the outcome hypotheses that had similar cost difference and RMS deviation (RMSD) with that of the initial hypothesis generated by Cat-Scramble validation test with 95% confidence level. Accordingly, our model should be reliable in identifying structurally diverse compounds with desired biological activity.
Shui-Ting Zhou,YiJui Chiu,Guo-Fei Yu,Chia-Hao Yang,Hong-Wu Huang,Sheng-Rui Jian 대한기계학회 2017 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.31 No.2
The Assumed mode method (AMM) and Finite element method (FEM) were used. Their results were compared to investigate the coupled shaft-torsion, disk-transverse, and blade-bending vibrations in a flexible-disk rotor system. The blades were grouped with a spring. The flexible-disk rotor system was divided into three modes of coupled vibrations: Shaft-disk-blade, disk-blade, and blade-blade. Two new modes of coupled vibrations were introduced, namely, lacing wires-blade and lacing wires-disk-blade. The patterns of change of the natural frequencies and mode shapes of the system were discussed. The results showed the following: first, mode shapes and natural frequencies varied, and the results of the AMM and FEM differed; second, numerical calculation results showed three influencing factors on natural frequencies, namely, the lacing wire constant, the lacing wire location, and the flexible disk; lastly, the flexible disk could affect the stability of the system as reflected in the effect of the rotational speed.
Shui Wang,Yixin Qu,Yizhen Du,Ping Zhang,Xiaowei Cheng 한국화학공학회 2014 Korean Journal of Chemical Engineering Vol.31 No.12
We studied the direct synthesis of 5-hydroxymethylfurfural (5-HMF) from cottonseed hull biomass underacid condition in one-pot. The influence of HCl dosage, reaction temperature and time, CrCl3·6H2O amount, and cotton-seed hull loading on the yield of 5-HMF was investigated. As a result, a 5-HMF yield up to 51% was obtained using 1-butyl-3-methylimidazolium chloride ([Bmim]Cl) catalyzed with chromium (III) chloride at 130 oC for 2 h. The [Bmim]Cl/CrCl3·6H2O/HCl system was found to have high activity and selectivity for the dehydration of cellulose into 5-hydroxy-methylfurfural. This work provides a low cost, environment-friendly and energy-efficient process to directly convertraw biomass into bio-fuels and chemicals.