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      • KCI등재

        Robot-assisted heminephrectomy for chromophobe renal cell carcinoma in L-shaped fused crossed ectopia: Surgical challenge

        Santosh Kumar,Shivanshu Singh,Siddharth Jain,Girdhar Singh Bora,Shrawan Kumar Singh 대한비뇨의학회 2015 Investigative and Clinical Urology Vol.56 No.10

        Renal cell carcinoma associated with fused ectopic kidneys has rarely been reported in the literature. Here we report the first case of robot-assisted heminephrectomy for chromophobe renal cell carcinoma in an L-shaped fused ectopic kidney. The present case report highlights the importance of three-dimensional vision and enhanced maneuverability with the EndoWrist technology of the robotic surgical system for precise dissection. This report also highlights the importance of preoperative contrast-enhanced computed tomography with three-dimensional arterial reconstruction for surgical planning.

      • KCI등재

        Comparative Efficacy of Tamsulosin Versus Tamsulosin With Tadalafil in Combination With Prednisolone for the Medical Expulsive Therapy of Lower Ureteric Stones: A Randomized Trial

        Santosh Kumar,Kumar Jayant,Swati Agrawal,Shrawan Kumar Singh 대한비뇨의학회 2014 Investigative and Clinical Urology Vol.55 No.3

        Purpose: To compare the safety and efficacy of tamsulosin and tamsulosin with thephosphodiesterase-5 inhibitor tadalafil in combination with prednisolone as medicalexpulsive therapies for lower ureteric stones. Materials and Methods: Between July 2011 and December 2012, 62 adult patients presentingwith distal ureteric stones sized 5 to 10 mm were randomized equally to treatmentwith tamsulosin (group A) or tamsulosin with tadalafil (group B). Therapy wasgiven for a maximum of 6 weeks. In addition, patients in groups A and B were given5-mg prednisolone once daily (maximum 1 week). The stone expulsion rate, time tostone expulsion, analgesic use, number of hospital visits for pain, follow-up and endoscopictreatment, and adverse effects of the drugs were noted. Statistical analyses weredone by using Student t-test and chi-square test. Results: There was a higher expulsion rate (83.9% in group B and 74.2% in group A)and a lower time to expulsion in both treatment groups than in historical controls usedin earlier studies. However, these results were not statistically significant (p=0.349,p=0.074, respectively). Statistically significant differences were noted in hospitalizationfor colic and analgesic requirement, which were less in group B than in groupA. There were no serious adverse events. Another important finding was improvementin erectile function in group B. Conclusions: Medical expulsive therapy for distal ureteric stones using tamsulosin andtadalafil with prednisolone is safe and efficacious. Also, the prescription of tadalafilin cases of erectile dysfunction with the development of lower ureteric stones may provideadditional advantages.

      • KCI등재

        Randomized Controlled Trial to Compare the Safety and Efficacy of Naftopidil and Tamsulosin as Medical Expulsive Therapy in Combination With Prednisolone for Distal Ureteral Stones

        Santosh Kumar,Kailash Chand Kurdia,Raguram Ganesamoni,Shrawan Kumar Singh,Bhuvanesh Nanjappa 대한비뇨의학회 2013 Investigative and Clinical Urology Vol.54 No.5

        Purpose: To compare the safety and efficacy of naftopidil and tamsulosin with prednisolone as medical expulsive therapy for distal ureteric stones. Materials and Methods: Between July 2010 and March 2012, 120 adult patients presenting with distal ureteric stones of size 5 to 10 mm were randomized equally to tamsulosin (group A), naftopidil (group B) or watchful waiting (group C). Tamsulosin or naftopidil was given for a maximum of four weeks. In addition patients in group A and B were given 5 mg prednisolone once daily (maximum one week). Stone expulsion rate,time to stone expulsion, analgesic use, number of hospital visits for pain, follow-up and endoscopic treatment and adverse effects of drugs were noted. Statistical analyses were done using chi-square test, Mann-Whitney test and analysis of variance. Results: There was a statistically higher expulsion rate in groups A (70%) and B (87.5%)as compared to group C (32.5%) (p<0.001). The expulsion rates were not statistically different between groups A and B (p=0.056). The mean time to expulsion was comparable between groups A and B but longer in group C. Analgesic use was significantly lower in groups A and B. Average number of hospital visits for pain, follow-up and endoscopic treatment was similar in all groups. There was no serious adverse event. Conclusions: Medical expulsive therapy for the distal ureteric stones using either naftopidil or tamsulosin in combination with prednisolone is safe and efficacious.

      • KCI등재

        Evaluation of low-dose dual energy computed tomography for in vivo assessment of renal/ureteric calculus composition

        Harshavardhan Mahalingam,Anupam Lal,Arup K Mandal,Shrawan Kumar Singh,Shalmoli Bhattacharyya,Niranjan Khandelwal 대한비뇨의학회 2015 Investigative and Clinical Urology Vol.56 No.8

        Purpose: This study aimed to assess the accuracy of low-dose dual-energy computed tomography (DECT) in predicting the compositionof urinary calculi. Materials and Methods: A total of 52 patients with urinary calculi were scanned with a 128-slice dual-source DECT scanner byuse of a low-dose protocol. Dual-energy (DE) ratio, weighted average Hounsfield unit (HU) of calculi, radiation dose, and imagenoise levels were recorded. Two radiologists independently rated study quality. Stone composition was assessed after extractionby Fourier transform infrared spectroscopy (FTIRS). Analysis of variance was used to determine if the differences in HU values andDE ratios between the various calculus groups were significant. Threshold cutoff values to classify the calculi into separate groupswere identified by receiver operating characteristic curve analysis. Results: A total of 137 calculi were detected. FTIRS analysis differentiated the calculi into five groups: uric acid (n=17), struvite(n=3), calcium oxalate monohydrate and dihydrate (COM-COD, n=84), calcium oxalate monohydrate (COM, n=28), and carbonateapatite (n=5). The HU value could differentiate only uric acid calculi from calcified calculi (p<0.001). The DE ratio could confidentlydifferentiate uric acid, struvite, calcium oxalate, and carbonate apatite calculi (p<0.001) with cutoff values of 1.12, 1.34, and 1.66,respectively, giving >80% sensitivity and specificity to differentiate them. The DE ratio could not differentiate COM from COM-CODcalculi. No study was rated poor in quality by either of the observers. The mean radiation dose was 1.8 mSv. Conclusions: Low-dose DECT accurately predicts urinary calculus composition in vivo while simultaneously reducing radiation exposurewithout compromising study quality.

      • KCI등재

        68Ga-PSMA-11 uptake in tracheal mucus plug – a potential pitfall

        Kunal Ramesh Chandekar,Apurva Sood,Kumar Rajender,Singh Harmandeep,Shrawan Kumar Singh 대한핵의학회 2022 핵의학 분자영상 Vol.56 No.1

        Prostate-specific membrane antigen (PSMA) PET/CT is a well-acclaimed imaging modality for prostate cancer (PCa). However, many reports have highlighted PSMA radioligand uptake in a variety of benign tumors and lesions. We report a case of PCa in which 68 Ga-PSMA-11 uptake was noted in the tracheal lumen. However, 18F-PSMA-1007 PET/CT was done on a subsequent day, which demonstrated no abnormal radiotracer uptake or morphological lesion within the tracheal lumen. This case highlights an uncommon finding of PSMA ligand uptake in a tracheal mucus plug (non-prostatic benign uptake), which may be misinterpreted as a false-positive finding.

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